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Results: 1 to 20 of 111

1.

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.

Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R.

Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.

PMID:
21873647
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.

Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Chesne C, van Delft J, Kleinjans J, Castell J, Bjorquist P, Herwig R, Rogiers V.

Carcinogenesis. 2013 Jun;34(6):1393-402. doi: 10.1093/carcin/bgt054. Epub 2013 Feb 7.

PMID:
23393228
[PubMed - indexed for MEDLINE]
Free Article
3.

Identification of potential biomarkers of genotoxicity and carcinogenicity in L5178Y mouse lymphoma cells by cDNA microarray analysis.

Kim JY, Kwon J, Kim JE, Koh WS, Chung MK, Yoon S, Song CW, Lee M.

Environ Mol Mutagen. 2005;45(1):80-9.

PMID:
15612046
[PubMed - indexed for MEDLINE]
4.

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH.

Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27.

PMID:
20106945
[PubMed - indexed for MEDLINE]
Free Article
5.

Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation.

Jozefczuk J, Prigione A, Chavez L, Adjaye J.

Stem Cells Dev. 2011 Jul;20(7):1259-75. doi: 10.1089/scd.2010.0361. Epub 2011 Jan 24.

PMID:
21162674
[PubMed - indexed for MEDLINE]
6.

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time.

Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH.

Toxicol Sci. 2009 Dec;112(2):374-84. doi: 10.1093/toxsci/kfp229. Epub 2009 Sep 21.

PMID:
19770486
[PubMed - indexed for MEDLINE]
Free Article
7.

Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.

van Kesteren PC, Zwart PE, Pennings JL, Gottschalk WH, Kleinjans JC, van Delft JH, van Steeg H, Luijten M.

Toxicol Sci. 2011 Sep;123(1):123-32. doi: 10.1093/toxsci/kfr169. Epub 2011 Jun 29.

PMID:
21715664
[PubMed - indexed for MEDLINE]
Free Article
8.

Evaluation of hepatotoxicity of chemicals using hepatic progenitor and hepatocyte-like cells derived from mouse embryonic stem cells: effect of chemicals on ESC-derived hepatocyte differentiation.

Kang SJ, Jeong SH, Kim EJ, Cho JH, Park YI, Park SW, Shin HS, Son SW, Kang HG.

Cell Biol Toxicol. 2013 Feb;29(1):1-11. doi: 10.1007/s10565-012-9223-0. Epub 2012 Oct 30.

PMID:
23108452
[PubMed - indexed for MEDLINE]
9.

Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens.

Rohrbeck A, Salinas G, Maaser K, Linge J, Salovaara S, Corvi R, Borlak J.

Toxicol Sci. 2010 Nov;118(1):31-41. doi: 10.1093/toxsci/kfq246. Epub 2010 Aug 16.

PMID:
20713471
[PubMed - indexed for MEDLINE]
Free Article
10.

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds.

Mathijs K, Brauers KJ, Jennen DG, Lizarraga D, Kleinjans JC, van Delft JH.

Mutagenesis. 2010 Nov;25(6):561-8. doi: 10.1093/mutage/geq040. Epub 2010 Jul 21.

PMID:
20650930
[PubMed - indexed for MEDLINE]
Free Article
11.

The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database.

Sasaki YF, Sekihashi K, Izumiyama F, Nishidate E, Saga A, Ishida K, Tsuda S.

Crit Rev Toxicol. 2000 Nov;30(6):629-799. Review.

PMID:
11145306
[PubMed - indexed for MEDLINE]
12.

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.

Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V.

Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/s00204-012-0847-x. Epub 2012 Apr 8.

PMID:
22484513
[PubMed - indexed for MEDLINE]
13.

Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further toward the hepatic lineage.

Synnergren J, Heins N, Brolén G, Eriksson G, Lindahl A, Hyllner J, Olsson B, Sartipy P, Björquist P.

Stem Cells Dev. 2010 Jul;19(7):961-78. doi: 10.1089/scd.2009.0220.

PMID:
19757991
[PubMed - indexed for MEDLINE]
14.

Hepatic differentiation of human embryonic stem cells is promoted by three-dimensional dynamic perfusion culture conditions.

Miki T, Ring A, Gerlach J.

Tissue Eng Part C Methods. 2011 May;17(5):557-68. doi: 10.1089/ten.TEC.2010.0437. Epub 2011 Feb 15.

PMID:
21210720
[PubMed - indexed for MEDLINE]
15.

NTP toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in female Harlan Sprague-Dawley rats (Gavage Studies).

National Toxicology Program.

Natl Toxicol Program Tech Rep Ser. 2006 Jan;(520):4-246.

PMID:
16628245
[PubMed - indexed for MEDLINE]
Free Article
16.

In vitro hepatic maturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers.

Ishii T, Yasuchika K, Fukumitsu K, Kawamoto T, Kawamura-Saitoh M, Amagai Y, Ikai I, Uemoto S, Kawase E, Suemori H, Nakatsuji N.

Cell Tissue Res. 2010 Mar;339(3):505-12. doi: 10.1007/s00441-009-0906-7. Epub 2009 Dec 30.

PMID:
20041263
[PubMed - indexed for MEDLINE]
17.

An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds.

Festag M, Viertel B, Steinberg P, Sehner C.

Toxicol In Vitro. 2007 Dec;21(8):1631-40. Epub 2007 Jul 18.

PMID:
17719739
[PubMed - indexed for MEDLINE]
18.

Liver carcinogenesis is not a predicted outcome of chemically induced hepatocyte proliferation.

Melnick RL, Huff J.

Toxicol Ind Health. 1993 May-Jun;9(3):415-38. Review.

PMID:
8367884
[PubMed - indexed for MEDLINE]
19.

Assessing compound carcinogenicity in vitro using connectivity mapping.

Caiment F, Tsamou M, Jennen D, Kleinjans J.

Carcinogenesis. 2014 Jan;35(1):201-7. doi: 10.1093/carcin/bgt278. Epub 2013 Aug 12.

PMID:
23940306
[PubMed - indexed for MEDLINE]
20.

Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy.

Ruhnke M, Nussler AK, Ungefroren H, Hengstler JG, Kremer B, Hoeckh W, Gottwald T, Heeckt P, Fandrich F.

Transplantation. 2005 May 15;79(9):1097-103.

PMID:
15880050
[PubMed - indexed for MEDLINE]

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