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Results: 1 to 20 of 102

1.

Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map.

Chen TJ, Blum K, Chen AL, Bowirrat A, Downs WB, Madigan MA, Waite RL, Bailey JA, Kerner M, Yeldandi S, Majmundar N, Giordano J, Morse S, Miller D, Fornari F, Braverman ER.

J Psychoactive Drugs. 2011 Apr-Jun;43(2):108-27.

PMID:
21858957
[PubMed - indexed for MEDLINE]
2.

Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative dopamine D₂ agonist therapy: part 2.

Blum K, Chen TJ, Morse S, Giordano J, Chen AL, Thompson J, Allen C, Smolen A, Lubar J, Stice E, Downs BW, Waite RL, Madigan MA, Kerner M, Fornari F, Braverman ER.

Postgrad Med. 2010 Nov;122(6):214-26. doi: 10.3810/pgm.2010.11.2237.

PMID:
21084796
[PubMed - indexed for MEDLINE]
3.

Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).

Blum K, Chen TJ, Downs BW, Bowirrat A, Waite RL, Braverman ER, Madigan M, Oscar-Berman M, DiNubile N, Stice E, Giordano J, Morse S, Gold M.

Postgrad Med. 2009 Nov;121(6):176-96. doi: 10.3810/pgm.2009.11.2087. Review.

PMID:
19940429
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: a hypothesis.

Blum K, Gold MS.

Med Hypotheses. 2011 Apr;76(4):576-84. doi: 10.1016/j.mehy.2011.01.005.

PMID:
21306831
[PubMed - indexed for MEDLINE]
5.

Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis.

Blum K, Chen TJ, Meshkin B, Waite RL, Downs BW, Blum SH, Mengucci JF, Arcuri V, Braverman ER, Palomo T.

Med Hypotheses. 2007;69(5):1054-60. Epub 2007 Apr 30.

PMID:
17467918
[PubMed - indexed for MEDLINE]
6.

Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports.

Miller DK, Bowirrat A, Manka M, Miller M, Stokes S, Manka D, Allen C, Gant C, Downs BW, Smolen A, Stevens E, Yeldandi S, Blum K.

Postgrad Med. 2010 Nov;122(6):188-213. doi: 10.3810/pgm.2010.11.2236. Review.

PMID:
21084795
[PubMed - indexed for MEDLINE]
7.

Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms.

Blum K, Oscar-Berman M, Stuller E, Miller D, Giordano J, Morse S, McCormick L, Downs WB, Waite RL, Barh D, Neal D, Braverman ER, Lohmann R, Borsten J, Hauser M, Han D, Liu Y, Helman M, Simpatico T.

J Addict Res Ther. 2012 Nov 27;3(5):139.

PMID:
23926462
[PubMed]
Free PMC Article
8.

Reward deficiency syndrome: genetic aspects of behavioral disorders.

Comings DE, Blum K.

Prog Brain Res. 2000;126:325-41. Review.

PMID:
11105655
[PubMed - indexed for MEDLINE]
9.

Addiction and brain reward and antireward pathways.

Gardner EL.

Adv Psychosom Med. 2011;30:22-60. doi: 10.1159/000324065. Epub 2011 Apr 19. Review.

PMID:
21508625
[PubMed - indexed for MEDLINE]
10.

Neurogenetic Impairments of Brain Reward Circuitry Links to Reward Deficiency Syndrome (RDS): Potential Nutrigenomic Induced Dopaminergic Activation.

Blum K, Oscar-Berman M, Giordano J, Downs B, Simpatico T, Han D, Femino J.

J Genet Syndr Gene Ther. 2012 Oct 17;3(4). pii: 1000e115.

PMID:
23264886
[PubMed]
Free PMC Article
11.

Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors.

Blum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D, Lubar JO, Chen TJ, Comings DE.

J Psychoactive Drugs. 2000 Nov;32 Suppl:i-iv, 1-112. Review.

PMID:
11280926
[PubMed - indexed for MEDLINE]
12.

Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric.

Blum K, Febo M, McLaughlin T, Cronjé FJ, Han D, Gold SM.

J Behav Addict. 2014 Sep;3(3):149-56. doi: 10.1556/JBA.3.2014.019. Epub 2014 Aug 26. Review.

PMID:
25317338
[PubMed]
Free PMC Article
13.

Dopamine Genetics and Function in Food and Substance Abuse.

Blum K, Oscar-Berman M, Barh D, Giordano J, Gold M.

J Genet Syndr Gene Ther. 2013 Feb 10;4(121). pii: 1000121.

PMID:
23543775
[PubMed]
Free PMC Article
14.

Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction.

Sweitzer MM, Donny EC, Hariri AR.

Drug Alcohol Depend. 2012 Jun;123 Suppl 1:S59-71. doi: 10.1016/j.drugalcdep.2012.01.017. Epub 2012 Feb 16. Review.

PMID:
22342427
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.

Blum K, Chen AL, Chen TJ, Braverman ER, Reinking J, Blum SH, Cassel K, Downs BW, Waite RL, Williams L, Prihoda TJ, Kerner MM, Palomo T, Comings DE, Tung H, Rhoades P, Oscar-Berman M.

Theor Biol Med Model. 2008 Nov 12;5:24. doi: 10.1186/1742-4682-5-24. Review.

PMID:
19014506
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review.

Noble EP.

Eur Psychiatry. 2000 Mar;15(2):79-89. Review.

PMID:
10881203
[PubMed - indexed for MEDLINE]
17.

The role of catechol-O-methyltransferase in reward processing and addiction.

Tunbridge EM, Huber A, Farrell SM, Stumpenhorst K, Harrison PJ, Walton ME.

CNS Neurol Disord Drug Targets. 2012 May;11(3):306-23. Review.

PMID:
22483300
[PubMed - indexed for MEDLINE]
18.

Stress, alcohol and drug interaction: an update of human research.

Uhart M, Wand GS.

Addict Biol. 2009 Jan;14(1):43-64. doi: 10.1111/j.1369-1600.2008.00131.x. Epub 2008 Oct 9. Review.

PMID:
18855803
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Early intervention of intravenous KB220IV--neuroadaptagen amino-acid therapy (NAAT) improves behavioral outcomes in a residential addiction treatment program: a pilot study.

Miller M, Chen AL, Stokes SD, Silverman S, Bowirrat A, Manka M, Manka D, Miller DK, Perrine K, Chen TJ, Bailey JA, Downs W, Waite RL, Madigan MA, Braverman ER, Damle U, Kerner M, Giordano J, Morse S, Oscar-Berman M, Barh D, Blum K.

J Psychoactive Drugs. 2012 Nov-Dec;44(5):398-409.

PMID:
23457891
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

"Liking" and "wanting" linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry.

Blum K, Gardner E, Oscar-Berman M, Gold M.

Curr Pharm Des. 2012;18(1):113-8.

PMID:
22236117
[PubMed - indexed for MEDLINE]
Free PMC Article
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