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Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.

Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L.

Dev Biol. 2011 Nov 1;359(1):1-11. doi: 10.1016/j.ydbio.2011.08.001. Epub 2011 Aug 11.


Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.

Kordowich S, Collombat P, Mansouri A, Serup P.

BMC Dev Biol. 2011 Aug 31;11:52. doi: 10.1186/1471-213X-11-52.


Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.

Mastracci TL, Anderson KR, Papizan JB, Sussel L.

PLoS Genet. 2013;9(2):e1003278. doi: 10.1371/journal.pgen.1003278. Epub 2013 Feb 7.


The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

Beucher A, Gjernes E, Collin C, Courtney M, Meunier A, Collombat P, Gradwohl G.

PLoS One. 2012;7(5):e36449. doi: 10.1371/journal.pone.0036449. Epub 2012 May 3.


Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population.

Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L.

PLoS One. 2012;7(12):e52026. doi: 10.1371/journal.pone.0052026. Epub 2012 Dec 12.


Genetic determinants of pancreatic epsilon-cell development.

Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P.

Dev Biol. 2005 Oct 1;286(1):217-24.


The Role of ARX in Human Pancreatic Endocrine Specification.

Gage BK, Asadi A, Baker RK, Webber TD, Wang R, Itoh M, Hayashi M, Miyata R, Akashi T, Kieffer TJ.

PLoS One. 2015 Dec 3;10(12):e0144100. doi: 10.1371/journal.pone.0144100. eCollection 2015.


Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.

Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L.

Mol Endocrinol. 2010 Feb;24(2):381-90. doi: 10.1210/me.2009-0360. Epub 2009 Dec 4.


Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.

Chao CS, Loomis ZL, Lee JE, Sussel L.

Dev Biol. 2007 Dec 15;312(2):523-32. Epub 2007 Oct 5.


Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.

Genes Dev. 2011 Nov 1;25(21):2291-305. doi: 10.1101/gad.173039.111.


Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS.

Development. 1998 Jun;125(12):2213-21.


Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.

Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G.

Development. 2010 Jan;137(2):203-12. doi: 10.1242/dev.041673.


Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A.

J Clin Invest. 2007 Apr;117(4):961-70.


The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.

Collombat P, Hecksher-Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A.

Development. 2005 Jul;132(13):2969-80. Epub 2005 Jun 1.


Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2924-9. Epub 2004 Feb 17.


Arx polyalanine expansion in mice leads to reduced pancreatic α-cell specification and increased α-cell death.

Wilcox CL, Terry NA, May CL.

PLoS One. 2013 Nov 13;8(11):e78741. doi: 10.1371/journal.pone.0078741. eCollection 2013.


Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss.

Wilcox CL, Terry NA, Walp ER, Lee RA, May CL.

PLoS One. 2013 Jun 13;8(6):e66214. doi: 10.1371/journal.pone.0066214. Print 2013.


Opposing actions of Arx and Pax4 in endocrine pancreas development.

Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P.

Genes Dev. 2003 Oct 15;17(20):2591-603.


Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine.

Desai S, Loomis Z, Pugh-Bernard A, Schrunk J, Doyle MJ, Minic A, McCoy E, Sussel L.

Dev Biol. 2008 Jan 1;313(1):58-66. Epub 2007 Oct 3.


Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.

Anderson KR, White P, Kaestner KH, Sussel L.

BMC Dev Biol. 2009 Dec 10;9:65. doi: 10.1186/1471-213X-9-65.

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