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Results: 1 to 20 of 99

1.

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.

Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R.

Channels (Austin). 2011 Sep-Oct;5(5):449-56. doi: 10.4161/chan.5.5.17363. Epub 2011 Sep 1.

PMID:
21829088
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.

Piekarz AD, Due MR, Khanna M, Wang B, Ripsch MS, Wang R, Meroueh SO, Vasko MR, White FA, Khanna R.

Mol Pain. 2012 Jul 24;8:54. doi: 10.1186/1744-8069-8-54.

PMID:
22828369
[PubMed - indexed for MEDLINE]
Free PMC Article
3.
4.

Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.

Wilson SM, Schmutzler BS, Brittain JM, Dustrude ET, Ripsch MS, Pellman JJ, Yeum TS, Hurley JH, Hingtgen CM, White FA, Khanna R.

J Biol Chem. 2012 Oct 12;287(42):35065-77. doi: 10.1074/jbc.M112.378695. Epub 2012 Aug 13.

PMID:
22891239
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.

Feldman P, Khanna R.

Neurosci Lett. 2013 Dec 17;557 Pt A:27-36. doi: 10.1016/j.neulet.2013.06.057. Epub 2013 Jul 3. Review.

PMID:
23831344
[PubMed - indexed for MEDLINE]
6.

Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model.

Brittain JM, Pan R, You H, Brustovetsky T, Brustovetsky N, Zamponi GW, Lee WH, Khanna R.

Channels (Austin). 2012 Jan-Feb;6(1):52-9. doi: 10.4161/chan.18919. Epub 2012 Jan 1.

PMID:
22373559
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.

Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, Cheon BM, Due MR, Brustovetsky T, Ashpole NM, Hudmon A, Meroueh SO, Hingtgen CM, Brustovetsky N, Ji RR, Hurley JH, Jin X, Shekhar A, Xu XM, Oxford GS, Vasko MR, White FA, Khanna R.

Nat Med. 2011 Jun 5;17(7):822-9. doi: 10.1038/nm.2345.

PMID:
21642979
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion.

Fischer G, Pan B, Vilceanu D, Hogan QH, Yu H.

Gene Ther. 2014 Jan;21(1):44-51. doi: 10.1038/gt.2013.56. Epub 2013 Oct 24.

PMID:
24152582
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

Jarvis MF, Scott VE, McGaraughty S, Chu KL, Xu J, Niforatos W, Milicic I, Joshi S, Zhang Q, Xia Z.

Biochem Pharmacol. 2014 Jun 15;89(4):536-44. doi: 10.1016/j.bcp.2014.03.015. Epub 2014 Apr 12.

PMID:
24726441
[PubMed - indexed for MEDLINE]
10.

Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide.

Ju W, Li Q, Allette YM, Ripsch MS, White FA, Khanna R.

J Neurochem. 2013 Mar;124(6):869-79. doi: 10.1111/jnc.12070. Epub 2013 Jan 20.

PMID:
23106100
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2).

Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A, White FA, Zamponi GW, Brustovetsky N, Chen J, Khanna R.

J Biol Chem. 2011 Oct 28;286(43):37778-92. doi: 10.1074/jbc.M111.255455. Epub 2011 Aug 9.

PMID:
21832084
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.

Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R.

J Biol Chem. 2009 Nov 6;284(45):31375-90. doi: 10.1074/jbc.M109.009951. Epub 2009 Sep 15.

PMID:
19755421
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.

Brustovetsky T, Pellman JJ, Yang XF, Khanna R, Brustovetsky N.

J Biol Chem. 2014 Mar 14;289(11):7470-82. doi: 10.1074/jbc.M113.518472. Epub 2014 Jan 28.

PMID:
24474686
[PubMed - indexed for MEDLINE]
14.

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons.

Chi XX, Schmutzler BS, Brittain JM, Wang Y, Hingtgen CM, Nicol GD, Khanna R.

J Cell Sci. 2009 Dec 1;122(Pt 23):4351-62. doi: 10.1242/jcs.053280. Epub 2009 Nov 10.

PMID:
19903690
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain.

Hofmann HA, De Vry J, Siegling A, Spreyer P, Denzer D.

Eur J Pharmacol. 2003 May 30;470(1-2):17-25.

PMID:
12787826
[PubMed - indexed for MEDLINE]
16.

Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats.

Ruangsri S, Lin A, Mulpuri Y, Lee K, Spigelman I, Nishimura I.

J Biol Chem. 2011 Nov 18;286(46):39836-47. doi: 10.1074/jbc.M111.261701. Epub 2011 Sep 30.

PMID:
21965668
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels.

Berecki G, Motin L, Haythornthwaite A, Vink S, Bansal P, Drinkwater R, Wang CI, Moretta M, Lewis RJ, Alewood PF, Christie MJ, Adams DJ.

Mol Pharmacol. 2010 Feb;77(2):139-48. doi: 10.1124/mol.109.058834. Epub 2009 Nov 5.

PMID:
19892914
[PubMed - indexed for MEDLINE]
Free Article
18.

Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence.

Meng G, Wu N, Zhang C, Su RB, Lu XQ, Liu Y, Yun LH, Zheng JQ, Li J.

Eur J Pharmacol. 2008 May 31;586(1-3):130-8. doi: 10.1016/j.ejphar.2008.02.066. Epub 2008 Feb 29.

PMID:
18374913
[PubMed - indexed for MEDLINE]
19.

Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain.

Becker A, Geisslinger G, Murín R, Grecksch G, Höllt V, Zimmer A, Schröder H.

Naunyn Schmiedebergs Arch Pharmacol. 2013 May;386(5):369-82. doi: 10.1007/s00210-013-0839-2. Epub 2013 Feb 1.

PMID:
23371449
[PubMed - indexed for MEDLINE]
20.

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures.

Parenti C, Turnaturi R, Aricò G, Gramowski-Voss A, Schroeder OH, Marrazzo A, Prezzavento O, Ronsisvalle S, Scoto GM, Ronsisvalle G, Pasquinucci L.

Neuropharmacology. 2013 Aug;71:70-82. doi: 10.1016/j.neuropharm.2013.03.008. Epub 2013 Mar 27.

PMID:
23541722
[PubMed - indexed for MEDLINE]

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