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Results: 1 to 20 of 122

1.

SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells.

Wang SX, Ju HQ, Liu KS, Zhang JX, Wang X, Xiang YF, Wang R, Liu JY, Liu QY, Xia M, Xing GW, Liu Z, Wang YF.

Biosci Biotechnol Biochem. 2011;75(8):1540-5. Epub 2011 Aug 7.

PMID:
21821931
[PubMed - indexed for MEDLINE]
Free Article
2.

The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways.

Wang R, Shao F, Liu Z, Zhang J, Wang S, Liu J, Liu H, Chen H, Liu K, Xia M, Wang Y.

Chem Biol Interact. 2013 Sep 5;205(1):1-10. doi: 10.1016/j.cbi.2013.06.007. Epub 2013 Jun 15.

PMID:
23777986
[PubMed - indexed for MEDLINE]
3.

The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo.

Liu KS, Ding WC, Wang SX, Liu Z, Xing GW, Wang Y, Wang YF.

Oncol Rep. 2012 Jun;27(6):1904-10. doi: 10.3892/or.2012.1738. Epub 2012 Mar 22.

PMID:
22447251
[PubMed - indexed for MEDLINE]
4.

P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells.

Cui Q, Yu JH, Wu JN, Tashiro S, Onodera S, Minami M, Ikejima T.

Acta Pharmacol Sin. 2007 Jul;28(7):1057-66.

PMID:
17588343
[PubMed - indexed for MEDLINE]
Free Article
5.

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers.

Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N, Solit DB.

Clin Cancer Res. 2008 Jan 1;14(1):240-8. doi: 10.1158/1078-0432.CCR-07-1667.

PMID:
18172276
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Novel C-terminal Hsp90 inhibitor for head and neck squamous cell cancer (HNSCC) with in vivo efficacy and improved toxicity profiles compared with standard agents.

Cohen SM, Mukerji R, Samadi AK, Zhang X, Zhao H, Blagg BS, Cohen MS.

Ann Surg Oncol. 2012 Jul;19 Suppl 3:S483-90. doi: 10.1245/s10434-011-1971-1. Epub 2011 Aug 12. Erratum in: Ann Surg Oncol. 2012 May;19(5):1720. Zhang, Xuan [added].

PMID:
21837531
[PubMed - indexed for MEDLINE]
7.

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK.

Okawa Y, Hideshima T, Steed P, Vallet S, Hall S, Huang K, Rice J, Barabasz A, Foley B, Ikeda H, Raje N, Kiziltepe T, Yasui H, Enatsu S, Anderson KC.

Blood. 2009 Jan 22;113(4):846-55. doi: 10.1182/blood-2008-04-151928. Epub 2008 Oct 23.

PMID:
18948577
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors.

Gloesenkamp C, Nitzsche B, Lim AR, Normant E, Vosburgh E, Schrader M, Ocker M, Scherübl H, Höpfner M.

Int J Oncol. 2012 May;40(5):1659-67. doi: 10.3892/ijo.2012.1328. Epub 2012 Jan 10.

PMID:
22246317
[PubMed - indexed for MEDLINE]
9.

The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.

Zhang J, Zheng Z, Zhao Y, Zhang T, Gu X, Yang W.

Clin Exp Med. 2013 Nov;13(4):323-8. doi: 10.1007/s10238-012-0208-3. Epub 2012 Sep 7.

PMID:
22955701
[PubMed - indexed for MEDLINE]
10.

HSP90 inhibition results in apoptosis of Philadelphia acute lymphoblastic leukaemia cells: an attractive prospect of new targeted agents.

Tavernier E, Flandrin-Gresta P, Solly F, Rigollet L, Cornillon J, Augeul-Meunier K, Stephan JL, Montmartin A, Viallet A, Guyotat D, Campos L.

J Cancer Res Clin Oncol. 2012 Oct;138(10):1753-8. Epub 2012 Jun 17.

PMID:
22706881
[PubMed - indexed for MEDLINE]
11.

Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.

Mehta PP, Whalen P, Baxi SM, Kung PP, Yamazaki S, Yin MJ.

Clin Cancer Res. 2011 Aug 15;17(16):5432-42. doi: 10.1158/1078-0432.CCR-11-0592. Epub 2011 Jun 29.

PMID:
21715568
[PubMed - indexed for MEDLINE]
Free Article
12.

A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis.

Lamoureux F, Thomas C, Yin MJ, Kuruma H, Fazli L, Gleave ME, Zoubeidi A.

Clin Cancer Res. 2011 Apr 15;17(8):2301-13. doi: 10.1158/1078-0432.CCR-10-3077. Epub 2011 Feb 24. Erratum in: Clin Cancer Res. 2011 Jul 15;17(14):4916.

PMID:
21349995
[PubMed - indexed for MEDLINE]
Free Article
13.

SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells.

Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, Xing GW, Wang SX, Wang YF.

Cancer Lett. 2012 May 28;318(2):180-8. doi: 10.1016/j.canlet.2011.12.015. Epub 2011 Dec 17.

PMID:
22182451
[PubMed - indexed for MEDLINE]
14.
15.

17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.

Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2348-56. doi: 10.1167/iovs.07-1305. Epub 2008 Feb 15.

PMID:
18281615
[PubMed - indexed for MEDLINE]
Free Article
16.

Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance.

Wong C, Chen S.

Cancer Res. 2009 Nov 15;69(22):8670-7. doi: 10.1158/0008-5472.CAN-09-1259. Epub 2009 Oct 27.

PMID:
19861537
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway.

Huang KF, Zhang GD, Huang YQ, Diao Y.

Int Immunopharmacol. 2012 Feb;12(2):334-41. doi: 10.1016/j.intimp.2011.12.004. Epub 2011 Dec 17.

PMID:
22182776
[PubMed - indexed for MEDLINE]
18.

Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells.

Choi YH, Yoo YH.

Oncol Rep. 2012 Dec;28(6):2163-9. doi: 10.3892/or.2012.2060. Epub 2012 Sep 26.

PMID:
23023313
[PubMed - indexed for MEDLINE]
19.

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

Bali P, Pranpat M, Swaby R, Fiskus W, Yamaguchi H, Balasis M, Rocha K, Wang HG, Richon V, Bhalla K.

Clin Cancer Res. 2005 Sep 1;11(17):6382-9.

PMID:
16144943
[PubMed - indexed for MEDLINE]
Free Article
20.

Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells.

Lee CS, Kim YJ, Lee SA, Myung SC, Kim W.

Basic Clin Pharmacol Toxicol. 2012 Sep;111(3):173-81. doi: 10.1111/j.1742-7843.2012.00883.x. Epub 2012 Apr 16.

PMID:
22433057
[PubMed - indexed for MEDLINE]

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