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Results: 1 to 20 of 106

1.

Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.

Alastalo TP, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Freeman BA, Chang HY, Rabinovitch M.

J Clin Invest. 2011 Sep;121(9):3735-46. doi: 10.1172/JCI43382. Epub 2011 Aug 8.

PMID:
21821917
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.

Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M.

J Clin Invest. 2008 May;118(5):1846-57. doi: 10.1172/JCI32503.

PMID:
18382765
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

PMID:
23525442
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M.

J Clin Invest. 2013 Aug 1;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.

PMID:
23867624
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways.

de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, Rabinovitch M.

J Cell Biol. 2009 Jan 12;184(1):83-99. doi: 10.1083/jcb.200806049.

PMID:
19139264
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

Teichert-Kuliszewska K, Kutryk MJ, Kuliszewski MA, Karoubi G, Courtman DW, Zucco L, Granton J, Stewart DJ.

Circ Res. 2006 Feb 3;98(2):209-17. Epub 2005 Dec 15.

PMID:
16357305
[PubMed - indexed for MEDLINE]
Free Article
7.

Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.

Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H.

Hypertens Res. 2010 May;33(5):435-45. doi: 10.1038/hr.2010.16. Epub 2010 Feb 26.

PMID:
20186146
[PubMed - indexed for MEDLINE]
8.

Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.

Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. doi: 10.1161/ATVBAHA.112.300121. Epub 2012 Nov 8.

PMID:
23139294
[PubMed - indexed for MEDLINE]
Free Article
9.

Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells.

Yu PB, Beppu H, Kawai N, Li E, Bloch KD.

J Biol Chem. 2005 Jul 1;280(26):24443-50. Epub 2005 May 9.

PMID:
15883158
[PubMed - indexed for MEDLINE]
Free Article
10.

Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.

Hagen M, Fagan K, Steudel W, Carr M, Lane K, Rodman DM, West J.

Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1473-9. Epub 2007 Feb 23.

PMID:
17322283
[PubMed - indexed for MEDLINE]
Free Article
11.

Involvement of BMPR2 in the protective effect of fluoxetine against monocrotaline-induced endothelial apoptosis in rats.

Wang Y, Zhang XH, Wang HL.

Can J Physiol Pharmacol. 2011 May;89(5):345-54. doi: 10.1139/y11-024. Epub 2011 May 27.

PMID:
21619414
[PubMed - indexed for MEDLINE]
12.
13.

BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.

Davies RJ, Holmes AM, Deighton J, Long L, Yang X, Barker L, Walker C, Budd DC, Upton PD, Morrell NW.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L604-15. doi: 10.1152/ajplung.00309.2011. Epub 2012 Jan 6.

PMID:
22227206
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice.

Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW.

Circ Res. 2006 Mar 31;98(6):818-27. Epub 2006 Feb 23.

PMID:
16497988
[PubMed - indexed for MEDLINE]
Free Article
15.

Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.

Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.

PMID:
17347486
[PubMed - indexed for MEDLINE]
Free Article
16.

Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW.

Circ Res. 2005 May 27;96(10):1053-63. Epub 2005 Apr 21.

PMID:
15845886
[PubMed - indexed for MEDLINE]
Free Article
17.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.

Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ.

Nat Med. 2013 Jan;19(1):74-82. doi: 10.1038/nm.3040. Epub 2012 Dec 23.

PMID:
23263626
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Physiologic and molecular consequences of endothelial Bmpr2 mutation.

Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J.

Respir Res. 2011 Jun 22;12:84. doi: 10.1186/1465-9921-12-84.

PMID:
21696628
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8.

Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, Erzurum SC, Aldred MA.

Am J Respir Crit Care Med. 2011 Dec 15;184(12):1400-8. doi: 10.1164/rccm.201106-1130OC. Epub 2011 Sep 15.

PMID:
21920918
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH.

Nasim MT, Ogo T, Chowdhury HM, Zhao L, Chen CN, Rhodes C, Trembath RC.

Hum Mol Genet. 2012 Jun 1;21(11):2548-58. doi: 10.1093/hmg/dds073. Epub 2012 Mar 2.

PMID:
22388934
[PubMed - indexed for MEDLINE]
Free Article

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