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Results: 1 to 20 of 95

1.

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs.

Toledo LI, Murga M, Fernandez-Capetillo O.

Mol Oncol. 2011 Aug;5(4):368-73. doi: 10.1016/j.molonc.2011.07.002. Epub 2011 Jul 28. Review.

PMID:
21820372
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.

J Biol Chem. 2005 Jan 14;280(2):1186-92. Epub 2004 Nov 8.

PMID:
15533933
[PubMed - indexed for MEDLINE]
Free Article
3.

Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.

PMID:
19060337
[PubMed - indexed for MEDLINE]
Free Article
4.

Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.

Lossaint G, Besnard E, Fisher D, Piette J, Dulić V.

Oncogene. 2011 Oct 13;30(41):4261-74. doi: 10.1038/onc.2011.135. Epub 2011 May 2.

PMID:
21532626
[PubMed - indexed for MEDLINE]
5.

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.

PMID:
20160494
[PubMed - indexed for MEDLINE]
Free Article
6.

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.

Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang JY, Sowin TJ, Rosenberg SH, Zhang H.

Int J Cancer. 2006 Dec 15;119(12):2784-94.

PMID:
17019715
[PubMed - indexed for MEDLINE]
7.

Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

Das KC, Dashnamoorthy R.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97. Epub 2003 Sep 5.

PMID:
12959929
[PubMed - indexed for MEDLINE]
Free Article
8.

Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.

Pan Y, Ren KH, He HW, Shao RG.

Cancer Biol Ther. 2009 Aug;8(16):1559-66. Epub 2009 Aug 8.

PMID:
19502782
[PubMed - indexed for MEDLINE]
Free Article
9.

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A.

J Biol Chem. 2009 Nov 27;284(48):33107-14. doi: 10.1074/jbc.M109.064485. Epub 2009 Oct 14.

PMID:
19828454
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.

Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M.

PLoS Genet. 2009 Jan;5(1):e1000324. doi: 10.1371/journal.pgen.1000324. Epub 2009 Jan 2.

PMID:
19119425
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.

Smith J, Tho LM, Xu N, Gillespie DA.

Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0. Review.

PMID:
21034966
[PubMed - indexed for MEDLINE]
12.

Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling.

Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P.

J Mol Biol. 2007 Sep 14;372(2):397-406. Epub 2007 Jul 3.

PMID:
17663993
[PubMed - indexed for MEDLINE]
13.

ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.

Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P.

J Invest Dermatol. 2009 Jul;129(7):1805-15. doi: 10.1038/jid.2008.435. Epub 2009 Feb 26.

PMID:
19242509
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells.

Furusawa Y, Iizumi T, Fujiwara Y, Hassan MA, Tabuchi Y, Nomura T, Kondo T.

Ultrason Sonochem. 2012 Nov;19(6):1246-51. doi: 10.1016/j.ultsonch.2012.04.003. Epub 2012 Apr 19.

PMID:
22571845
[PubMed - indexed for MEDLINE]
15.

Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.

Wilsker D, Chung JH, Bunz F.

Cell Cycle. 2012 Apr 15;11(8):1564-72. doi: 10.4161/cc.19944. Epub 2012 Apr 15.

PMID:
22433954
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.

Bork U, Lee WK, Kuchler A, Dittmar T, Thévenod F.

Am J Physiol Renal Physiol. 2010 Feb;298(2):F255-65. doi: 10.1152/ajprenal.00273.2009. Epub 2009 Nov 18.

PMID:
19923412
[PubMed - indexed for MEDLINE]
Free Article
17.

UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway.

Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA.

J Cell Sci. 2013 May 1;126(Pt 9):1923-30. doi: 10.1242/jcs.118265. Epub 2013 Feb 27.

PMID:
23447674
[PubMed - indexed for MEDLINE]
Free Article
19.

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK.

J Biol Chem. 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.

PMID:
12588868
[PubMed - indexed for MEDLINE]
Free Article
20.

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.

López-Contreras AJ, Gutierrez-Martinez P, Specks J, Rodrigo-Perez S, Fernandez-Capetillo O.

J Exp Med. 2012 Mar 12;209(3):455-61. doi: 10.1084/jem.20112147. Epub 2012 Feb 27.

PMID:
22370720
[PubMed - indexed for MEDLINE]
Free PMC Article

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