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Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice.

Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD.

J Invest Dermatol. 2011 Nov;131(11):2289-97. doi: 10.1038/jid.2011.196. Epub 2011 Aug 4.


1α,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway.

Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD.

J Steroid Biochem Mol Biol. 2013 Jul;136:229-32. doi: 10.1016/j.jsbmb.2012.09.024. Epub 2012 Sep 28. Review.


The vitamin D receptor: a tumor suppressor in skin.

Bikle DD.

Discov Med. 2011 Jan;11(56):7-17.


Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis.

Ellison TI, Smith MK, Gilliam AC, MacDonald PN.

J Invest Dermatol. 2008 Oct;128(10):2508-17. doi: 10.1038/jid.2008.131. Epub 2008 May 29.


Interaction of hedgehog and vitamin D signaling pathways in basal cell carcinomas.

Albert B, Hahn H.

Adv Exp Med Biol. 2014;810:329-41. Review.


Protective role of vitamin D signaling in skin cancer formation.

Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A.

J Steroid Biochem Mol Biol. 2013 Jul;136:271-9. doi: 10.1016/j.jsbmb.2012.09.021. Epub 2012 Oct 8. Review.


Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice.

Teichert A, Elalieh H, Bikle D.

J Cell Physiol. 2010 Nov;225(2):482-9. doi: 10.1002/jcp.22227.


Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis.

Zinser GM, Sundberg JP, Welsh J.

Carcinogenesis. 2002 Dec;23(12):2103-9.


Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.

Uhmann A, Niemann H, Lammering B, Henkel C, Hess I, Nitzki F, Fritsch A, Prüfer N, Rosenberger A, Dullin C, Schraepler A, Reifenberger J, Schweyer S, Pietsch T, Strutz F, Schulz-Schaeffer W, Hahn H.

Mol Cancer Ther. 2011 Nov;10(11):2179-88. doi: 10.1158/1535-7163.MCT-11-0422. Epub 2011 Aug 30.


Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer.

Bikle DD, Oda Y, Tu CL, Jiang Y.

J Steroid Biochem Mol Biol. 2015 Apr;148:47-51. doi: 10.1016/j.jsbmb.2014.10.017. Epub 2014 Oct 31. Review.


Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues.

Zinser GM, Suckow M, Welsh J.

J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):153-64. Epub 2005 Aug 18.


Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.

Xu J, Weng Z, Arumugam A, Tang X, Chaudhary SC, Li C, Christiano AM, Elmets CA, Bickers DR, Athar M.

Am J Pathol. 2014 May;184(5):1529-40. doi: 10.1016/j.ajpath.2014.01.013. Epub 2014 Mar 12.


Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development.

Chang PL, Hsieh YH, Wang CC, Juliana MM, Tsuruta Y, Timares L, Elmets C, Ho KJ.

J Dermatol Sci. 2014 Aug;75(2):121-32. doi: 10.1016/j.jdermsci.2014.05.002. Epub 2014 May 21.


Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity.

Villani RM, Adolphe C, Palmer J, Waters MJ, Wainwright BJ.

Cancer Prev Res (Phila). 2010 Oct;3(10):1222-34. doi: 10.1158/1940-6207.CAPR-10-0082. Epub 2010 Sep 21.


Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells.

Sachs N, Secades P, van Hulst L, Kreft M, Song JY, Sonnenberg A.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21468-73. doi: 10.1073/pnas.1204614110. Epub 2012 Dec 10.


DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.

Uhmann A, Heß I, Frommhold A, König S, Zabel S, Nitzki F, Dittmann K, Lühder F, Christiansen H, Reifenberger J, Schulz-Schaeffer W, Hahn H.

J Invest Dermatol. 2014 Oct;134(10):2620-9. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24.


The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes.

Lisse TS, Saini V, Zhao H, Luderer HF, Gori F, Demay MB.

Mol Endocrinol. 2014 Oct;28(10):1698-706. doi: 10.1210/me.2014-1043. Epub 2014 Sep 2.


The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin.

Dowd DR, MacDonald PN.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):317-21. doi: 10.1016/j.jsbmb.2010.03.072. Epub 2010 Apr 1. Review.


Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation.

Capozza F, Williams TM, Schubert W, McClain S, Bouzahzah B, Sotgia F, Lisanti MP.

Am J Pathol. 2003 Jun;162(6):2029-39.


A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis.

Gu D, Fan Q, Zhang X, Xie J.

J Biol Chem. 2012 Nov 2;287(45):38356-66. doi: 10.1074/jbc.M112.377382. Epub 2012 Sep 19.

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