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Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis.

Mlitz V, Latreille J, Gardinier S, Jdid R, Drouault Y, Hufnagl P, Eckhart L, Guinot C, Tschachler E.

J Eur Acad Dermatol Venereol. 2012 Aug;26(8):983-90. doi: 10.1111/j.1468-3083.2011.04198.x. Epub 2011 Aug 4.


Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.

Kezic S, O'Regan GM, Yau N, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, McLean WH, Irvine AD.

Allergy. 2011 Jul;66(7):934-40. doi: 10.1111/j.1398-9995.2010.02540.x. Epub 2011 Jan 25.


Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.

Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD.

J Allergy Clin Immunol. 2012 Apr;129(4):1031-9.e1. doi: 10.1016/j.jaci.2011.12.989. Epub 2012 Feb 8.


Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes.

O'Regan GM, Kemperman PM, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Puppels GJ, McLean WH, Caspers PJ, Irvine AD.

J Allergy Clin Immunol. 2010 Sep;126(3):574-80.e1. doi: 10.1016/j.jaci.2010.04.038.


Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema.

Jungersted JM, Scheer H, Mempel M, Baurecht H, Cifuentes L, Høgh JK, Hellgren LI, Jemec GB, Agner T, Weidinger S.

Allergy. 2010 Jul;65(7):911-8. doi: 10.1111/j.1398-9995.2010.02326.x. Epub 2010 Feb 4.


Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods.

Kezic S, Kammeyer A, Calkoen F, Fluhr JW, Bos JD.

Br J Dermatol. 2009 Nov;161(5):1098-104. doi: 10.1111/j.1365-2133.2009.09342.x. Erratum in: Br J Dermatol. 2009 Dec;161(6):1423.


Decreased lactate and potassium levels in natural moisturizing factor from the stratum corneum of mild atopic dermatitis patients are involved with the reduced hydration state.

Sugawara T, Kikuchi K, Tagami H, Aiba S, Sakai S.

J Dermatol Sci. 2012 May;66(2):154-9. doi: 10.1016/j.jdermsci.2012.02.011. Epub 2012 Mar 1.


Analysis of filaggrin mutations and expression in corneal specimens from patients with or without atopic dermatitis.

Lapp T, Auw-Haedrich C, Reinhard T, Evans R, Rodríguez E, Weidinger S, Jakob T.

Int Arch Allergy Immunol. 2014;163(1):20-4. doi: 10.1159/000355965. Epub 2013 Nov 16.


Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect.

Brown SJ, Kroboth K, Sandilands A, Campbell LE, Pohler E, Kezic S, Cordell HJ, McLean WH, Irvine AD.

J Invest Dermatol. 2012 Jan;132(1):98-104. doi: 10.1038/jid.2011.342. Epub 2011 Nov 10.


Clinical severity correlates with impaired barrier in filaggrin-related eczema.

Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H.

J Invest Dermatol. 2009 Mar;129(3):682-9. doi: 10.1038/jid.2008.280. Epub 2008 Sep 25.


Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations.

Chen H, Common JE, Haines RL, Balakrishnan A, Brown SJ, Goh CS, Cordell HJ, Sandilands A, Campbell LE, Kroboth K, Irvine AD, Goh DL, Tang MB, van Bever HP, Giam YC, McLean WH, Lane EB.

Br J Dermatol. 2011 Jul;165(1):106-14. doi: 10.1111/j.1365-2133.2011.10331.x.


Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.

Winge MC, Bilcha KD, Liedén A, Shibeshi D, Sandilands A, Wahlgren CF, McLean WH, Nordenskjöld M, Bradley M.

Br J Dermatol. 2011 Nov;165(5):1074-80. doi: 10.1111/j.1365-2133.2011.10475.x. Epub 2011 Oct 17.


Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice.

Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M.

J Allergy Clin Immunol. 2012 Jun;129(6):1538-46.e6. doi: 10.1016/j.jaci.2012.01.068. Epub 2012 Mar 10.


Common FLG mutation K4671X not associated with atopic dermatitis in Han Chinese in a family association study.

Cheng R, Li M, Zhang H, Guo Y, Chen X, Tao J, Jiang A, Gan J, Qi H, Yu H, Liao W, Yao Z.

PLoS One. 2012;7(11):e49158. doi: 10.1371/journal.pone.0049158. Epub 2012 Nov 13.


Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

Pellerin L, Henry J, Hsu CY, Balica S, Jean-Decoster C, Méchin MC, Hansmann B, Rodriguez E, Weindinger S, Schmitt AM, Serre G, Paul C, Simon M.

J Allergy Clin Immunol. 2013 Apr;131(4):1094-102. doi: 10.1016/j.jaci.2012.12.1566. Epub 2013 Feb 10.


Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis.

González FJ, Alda J, Moreno-Cruz B, Martínez-Escanamé M, Ramírez-Elías MG, Torres-Álvarez B, Moncada B.

Skin Res Technol. 2011 Feb;17(1):45-50. doi: 10.1111/j.1600-0846.2010.00461.x.


Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV.

Li M, Cheng R, Shi M, Liu J, Zhang G, Liu Q, Yu H, Yao Z.

Br J Dermatol. 2013 Jun;168(6):1335-8. doi: 10.1111/bjd.12206. Epub 2013 Apr 1.


Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.

Winge MC, Hoppe T, Berne B, Vahlquist A, Nordenskjöld M, Bradley M, Törmä H.

PLoS One. 2011;6(12):e28254. doi: 10.1371/journal.pone.0028254. Epub 2011 Dec 2.


Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis.

Visser MJ, Landeck L, Campbell LE, McLean WH, Weidinger S, Calkoen F, John SM, Kezic S.

Br J Dermatol. 2013 Feb;168(2):326-32. doi: 10.1111/bjd.12083.


Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy.

Carlsen BC, Thyssen JP, Menné T, Meldgaard M, Linneberg A, Nielsen NH, Szecsi PB, Stender S, Johansen JD.

Clin Exp Dermatol. 2011 Jul;36(5):467-72. doi: 10.1111/j.1365-2230.2010.03994.x. Epub 2011 Mar 11.

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