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Results: 1 to 20 of 140

1.

Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.

Murugan RN, Park JE, Kim EH, Shin SY, Cheong C, Lee KS, Bang JK.

Mol Cells. 2011 Sep;32(3):209-20. doi: 10.1007/s10059-011-0126-3. Epub 2011 Jul 29. Review.

PMID:
21809214
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation.

Li L, Wang X, Chen J, Ding H, Zhang Y, Hu TC, Hu LH, Jiang HL, Shen X.

Acta Pharmacol Sin. 2009 Oct;30(10):1443-53. doi: 10.1038/aps.2009.141.

PMID:
19801998
[PubMed - indexed for MEDLINE]
Free Article
3.

Pinning down the polo-box domain.

Lee KS, Idle JR.

Chem Biol. 2008 May;15(5):415-6. doi: 10.1016/j.chembiol.2008.04.009.

PMID:
18482691
[PubMed - indexed for MEDLINE]
Free Article
4.

A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay.

Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S.

PLoS One. 2013 Apr 26;8(4):e53317. doi: 10.1371/journal.pone.0053317. Print 2013.

PMID:
23658603
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Polo-like kinases inhibitors.

Garuti L, Roberti M, Bottegoni G.

Curr Med Chem. 2012;19(23):3937-48. Review.

PMID:
22709006
[PubMed - indexed for MEDLINE]
6.

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.

Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK.

Bioorg Med Chem. 2013 May 1;21(9):2623-34. doi: 10.1016/j.bmc.2013.02.020. Epub 2013 Feb 27.

PMID:
23498919
[PubMed - indexed for MEDLINE]
7.

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting.

Hanisch A, Wehner A, Nigg EA, Silljé HH.

Mol Biol Cell. 2006 Jan;17(1):448-59. Epub 2005 Nov 2.

PMID:
16267267
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

 p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.

Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J.

Cell Cycle. 2012 Feb 1;11(3):543-53. doi: 10.4161/cc.11.3.19076. Epub 2012 Feb 1.

PMID:
22262171
[PubMed - indexed for MEDLINE]
9.

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.

Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR Jr, Yaffe MB, Wlodawer A, Lee KS.

Nat Struct Mol Biol. 2009 Aug;16(8):876-82. doi: 10.1038/nsmb.1628. Epub 2009 Jul 13. Erratum in: Nat Struct Mol Biol. 2011 Apr;18(4):516.

PMID:
19597481
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Phosphopeptides with improved cellular uptake properties as ligands for the polo-box domain of polo-like kinase 1.

Richter S, Neundorf I, Loebner K, Gräber M, Berg T, Bergmann R, Steinbach J, Pietzsch J, Wuest F.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4686-9. doi: 10.1016/j.bmcl.2011.06.103. Epub 2011 Jun 30.

PMID:
21778054
[PubMed - indexed for MEDLINE]
11.

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

Wipf P, Arnold D, Carter K, Dong S, Johnston PA, Sharlow E, Lazo JS, Huryn D.

Curr Top Med Chem. 2009;9(13):1194-205. Review.

PMID:
19807663
[PubMed - indexed for MEDLINE]
12.

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.

McInnes C, Estes K, Baxter M, Yang Z, Farag DB, Johnston P, Lazo JS, Wang J, Wyatt MD.

Mol Cancer Ther. 2012 Aug;11(8):1683-92. doi: 10.1158/1535-7163.MCT-12-0006-T. Epub 2012 Jul 30.

PMID:
22848093
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition.

Watanabe N, Sekine T, Takagi M, Iwasaki J, Imamoto N, Kawasaki H, Osada H.

J Biol Chem. 2009 Jan 23;284(4):2344-53. doi: 10.1074/jbc.M805308200. Epub 2008 Nov 25.

PMID:
19033445
[PubMed - indexed for MEDLINE]
Free Article
14.

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1.

Reindl W, Strebhardt K, Berg T.

Anal Biochem. 2008 Dec 15;383(2):205-9. doi: 10.1016/j.ab.2008.08.014. Epub 2008 Aug 22.

PMID:
18793607
[PubMed - indexed for MEDLINE]
15.

Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.

Yuan J, Sanhaji M, Krämer A, Reindl W, Hofmann M, Kreis NN, Zimmer B, Berg T, Strebhardt K.

Am J Pathol. 2011 Oct;179(4):2091-9. doi: 10.1016/j.ajpath.2011.06.031. Epub 2011 Aug 10.

PMID:
21839059
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural basis for the inhibition of Polo-like kinase 1.

Xu J, Shen C, Wang T, Quan J.

Nat Struct Mol Biol. 2013 Sep;20(9):1047-53. doi: 10.1038/nsmb.2623. Epub 2013 Jul 28.

PMID:
23893132
[PubMed - indexed for MEDLINE]
17.

Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.

Elling RA, Fucini RV, Romanowski MJ.

Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):909-18. doi: 10.1107/S0907444908019513. Epub 2008 Aug 13.

PMID:
18703838
[PubMed - indexed for MEDLINE]
18.
19.

Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets.

Ding Y, Huang D, Zhang Z, Smith J, Petillo D, Looyenga BD, Feenstra K, Mackeigan JP, Furge KA, Teh BT.

Cancer Res. 2011 Aug 1;71(15):5225-34. doi: 10.1158/0008-5472.CAN-11-0076. Epub 2011 Jun 3.

PMID:
21642374
[PubMed - indexed for MEDLINE]
Free Article
20.

Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.

Elling RA, Fucini RV, Hanan EJ, Barr KJ, Zhu J, Paulvannan K, Yang W, Romanowski MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Aug 1;64(Pt 8):686-91. doi: 10.1107/S1744309108019623. Epub 2008 Jul 26.

PMID:
18678933
[PubMed - indexed for MEDLINE]
Free PMC Article

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