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Results: 1 to 20 of 102

1.

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA Jr.

Amino Acids. 2012 Feb;42(2-3):887-98. doi: 10.1007/s00726-011-1004-1. Epub 2011 Jul 30.

PMID:
21805138
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells.

Huang Y, Vasilatos SN, Boric L, Shaw PG, Davidson NE.

Breast Cancer Res Treat. 2012 Feb;131(3):777-89. doi: 10.1007/s10549-011-1480-8. Epub 2011 Mar 31.

PMID:
21452019
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology.

Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, Kirfel J.

Carcinogenesis. 2010 Mar;31(3):512-20. doi: 10.1093/carcin/bgp324. Epub 2009 Dec 30.

PMID:
20042638
[PubMed - indexed for MEDLINE]
Free Article
4.

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.

Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA Jr.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8023-8. Epub 2007 Apr 26.

PMID:
17463086
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.

PMID:
23508577
[PubMed - in process]
Free PMC Article
6.

Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene.

Zhu Q, Liu C, Ge Z, Fang X, Zhang X, Strååt K, Björkholm M, Xu D.

PLoS One. 2008 Jan 16;3(1):e1446. doi: 10.1371/journal.pone.0001446.

PMID:
18197256
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Polyamine analogues targeting epigenetic gene regulation.

Huang Y, Marton LJ, Woster PM, Casero RA.

Essays Biochem. 2009 Nov 4;46:95-110. doi: 10.1042/bse0460007. Review.

PMID:
20095972
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.

Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG.

ACS Chem Biol. 2012 Jul 20;7(7):1221-31. doi: 10.1021/cb300108c. Epub 2012 May 10.

PMID:
22533360
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.

Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA.

Biochem J. 2013 Jan 15;449(2):459-68. doi: 10.1042/BJ20121360.

PMID:
23072722
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA Jr.

Clin Cancer Res. 2009 Dec 1;15(23):7217-28. doi: 10.1158/1078-0432.CCR-09-1293. Epub 2009 Nov 24.

PMID:
19934284
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.

Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y.

Carcinogenesis. 2013 Jun;34(6):1196-207. doi: 10.1093/carcin/bgt033. Epub 2013 Jan 25.

PMID:
23354309
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1.

Opel M, Lando D, Bonilla C, Trewick SC, Boukaba A, Walfridsson J, Cauwood J, Werler PJ, Carr AM, Kouzarides T, Murzina NV, Allshire RC, Ekwall K, Laue ED.

PLoS One. 2007 Apr 18;2(4):e386.

PMID:
17440621
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.

Metzger E, Wissmann M, Yin N, Müller JM, Schneider R, Peters AH, Günther T, Buettner R, Schüle R.

Nature. 2005 Sep 15;437(7057):436-9. Epub 2005 Aug 3.

PMID:
16079795
[PubMed - indexed for MEDLINE]
14.

Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes.

Vicent GP, Nacht AS, Zaurin R, Font-Mateu J, Soronellas D, Le Dily F, Reyes D, Beato M.

Genes Dev. 2013 May 15;27(10):1179-97. doi: 10.1101/gad.215293.113.

PMID:
23699411
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.

Willmann D, Lim S, Wetzel S, Metzger E, Jandausch A, Wilk W, Jung M, Forne I, Imhof A, Janzer A, Kirfel J, Waldmann H, Schüle R, Buettner R.

Int J Cancer. 2012 Dec 1;131(11):2704-9. doi: 10.1002/ijc.27555. Epub 2012 Jun 28.

PMID:
22447389
[PubMed - indexed for MEDLINE]
16.

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R.

Nature. 2010 Apr 1;464(7289):792-6. doi: 10.1038/nature08839. Epub 2010 Mar 14.

PMID:
20228790
[PubMed - indexed for MEDLINE]
17.

Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure.

Woodfield GW, Hitchler MJ, Chen Y, Domann FE, Weigel RJ.

Clin Cancer Res. 2009 Jun 1;15(11):3672-9. doi: 10.1158/1078-0432.CCR-08-2343. Epub 2009 May 19.

PMID:
19458056
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.

Pogribny IP, Tryndyak VP, Pogribna M, Shpyleva S, Surratt G, Gamboa da Costa G, Beland FA.

Int J Oncol. 2013 May;42(5):1822-32. doi: 10.3892/ijo.2013.1855. Epub 2013 Mar 12.

PMID:
23483119
[PubMed - indexed for MEDLINE]
19.

The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.

Tang M, Shen H, Jin Y, Lin T, Cai Q, Pinard MA, Biswas S, Tran Q, Li G, Shenoy AK, Tongdee E, Lin S, Gu Y, Law BK, Zhou L, McKenna R, Wu L, Lu J.

J Biol Chem. 2013 Sep 20;288(38):27680-91. doi: 10.1074/jbc.M113.482349. Epub 2013 Aug 8.

PMID:
23928305
[PubMed - indexed for MEDLINE]
20.

Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition.

Kinyamu HK, Collins JB, Grissom SF, Hebbar PB, Archer TK.

Mol Carcinog. 2008 Nov;47(11):845-85. doi: 10.1002/mc.20440.

PMID:
18381591
[PubMed - indexed for MEDLINE]
Free PMC Article

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