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Results: 1 to 20 of 106

1.

Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model.

Saminathan H, Asaithambi A, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurotoxicology. 2011 Oct;32(5):567-77. doi: 10.1016/j.neuro.2011.06.009. Epub 2011 Jul 23.

PMID:
21801747
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells.

Kaul S, Anantharam V, Yang Y, Choi CJ, Kanthasamy A, Kanthasamy AG.

J Biol Chem. 2005 Aug 5;280(31):28721-30. Epub 2005 Jun 16.

PMID:
15961393
[PubMed - indexed for MEDLINE]
Free Article
3.
4.

Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease.

Latchoumycandane C, Anantharam V, Jin H, Kanthasamy A, Kanthasamy A.

Toxicol Appl Pharmacol. 2011 Nov 1;256(3):314-23. doi: 10.1016/j.taap.2011.07.021. Epub 2011 Aug 6.

PMID:
21846476
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease.

Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A.

Mol Brain. 2008 Oct 22;1:12. doi: 10.1186/1756-6606-1-12.

PMID:
18945348
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation.

Gordon R, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Neuroinflammation. 2012 Apr 27;9:82. doi: 10.1186/1742-2094-9-82.

PMID:
22540228
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease.

Afeseh Ngwa H, Kanthasamy A, Anantharam V, Song C, Witte T, Houk R, Kanthasamy AG.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):273-85. doi: 10.1016/j.taap.2009.07.025. Epub 2009 Jul 29.

PMID:
19646462
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

Latchoumycandane C, Anantharam V, Kitazawa M, Yang Y, Kanthasamy A, Kanthasamy AG.

J Pharmacol Exp Ther. 2005 Apr;313(1):46-55. Epub 2004 Dec 17.

PMID:
15608081
[PubMed - indexed for MEDLINE]
Free Article
9.

Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.

Anantharam V, Kitazawa M, Latchoumycandane C, Kanthasamy A, Kanthasamy AG.

Ann N Y Acad Sci. 2004 Dec;1035:271-89.

PMID:
15681813
[PubMed - indexed for MEDLINE]
10.

Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2.

Kitazawa M, Anantharam V, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2004 Jun;25(4):589-98.

PMID:
15183012
[PubMed - indexed for MEDLINE]
11.
12.

A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.

Kanthasamy AG, Anantharam V, Zhang D, Latchoumycandane C, Jin H, Kaul S, Kanthasamy A.

Free Radic Biol Med. 2006 Nov 15;41(10):1578-89. Epub 2006 Aug 25.

PMID:
17045926
[PubMed - indexed for MEDLINE]
13.

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.

Sun F, Kanthasamy A, Song C, Yang Y, Anantharam V, Kanthasamy AG.

J Cell Mol Med. 2008 Dec;12(6A):2467-81. doi: 10.1111/j.1582-4934.2008.00293.x. Epub 2008 Feb 24.

PMID:
18298651
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration.

Asaithambi A, Kanthasamy A, Saminathan H, Anantharam V, Kanthasamy AG.

Mol Neurodegener. 2011 Jun 22;6:43. doi: 10.1186/1750-1326-6-43.

PMID:
21696630
[PubMed]
Free PMC Article
15.

Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration.

Song C, Kanthasamy A, Anantharam V, Sun F, Kanthasamy AG.

Mol Pharmacol. 2010 Apr;77(4):621-32. doi: 10.1124/mol.109.062174. Epub 2010 Jan 22.

PMID:
20097775
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease.

Kanthasamy AG, Kitazawa M, Kaul S, Yang Y, Lahiri DK, Anantharam V, Kanthasamy A.

Ann N Y Acad Sci. 2003 Dec;1010:683-6.

PMID:
15033812
[PubMed - indexed for MEDLINE]
17.
18.

Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.

Kitazawa M, Anantharam V, Yang Y, Hirata Y, Kanthasamy A, Kanthasamy AG.

Biochem Pharmacol. 2005 Jan 1;69(1):133-46.

PMID:
15588722
[PubMed - indexed for MEDLINE]
19.

Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.

Kaul S, Anantharam V, Kanthasamy A, Kanthasamy AG.

Brain Res Mol Brain Res. 2005 Sep 13;139(1):137-52.

PMID:
15978696
[PubMed - indexed for MEDLINE]
20.

Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration.

Yang Y, Kaul S, Zhang D, Anantharam V, Kanthasamy AG.

Mol Cell Neurosci. 2004 Mar;25(3):406-21.

PMID:
15033169
[PubMed - indexed for MEDLINE]
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