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Items: 1 to 20 of 156


ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer.

Kennedy BA, Deatherage DE, Gu F, Tang B, Chan MW, Nephew KP, Huang TH, Jin VX.

PLoS One. 2011;6(7):e22606. doi: 10.1371/journal.pone.0022606. Epub 2011 Jul 25.


GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion.

Sun J, He H, Pillai S, Xiong Y, Challa S, Xu L, Chellappan S, Yang S.

J Biol Chem. 2013 Dec 27;288(52):36971-82. doi: 10.1074/jbc.M113.506535. Epub 2013 Nov 14.


Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer.

Yeh KT, Chen TH, Yang HW, Chou JL, Chen LY, Yeh CM, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, Huang TH, Lai HC, Chan MW.

Epigenetics. 2011 Jun;6(6):727-39. Epub 2011 Jun 1.


Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer.

Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJ, Davuluri RV, Chao TK, Nephew KP, Huang TH, Lai HC, Chan MW.

Lab Invest. 2010 Mar;90(3):414-25. doi: 10.1038/labinvest.2009.138. Epub 2010 Jan 11.


The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner.

Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A, Tolosa EJ, Ellenrieder V, Fernandez-Zapico ME.

J Biol Chem. 2014 May 30;289(22):15495-506. doi: 10.1074/jbc.M113.545194. Epub 2014 Apr 16.


Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells.

Yu SL, Lee DC, Son JW, Park CG, Lee HY, Kang J.

Oncol Rep. 2013 Sep;30(3):1293-300. doi: 10.3892/or.2013.2578. Epub 2013 Jul 1.


ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.

Li H, Bitler BG, Vathipadiekal V, Maradeo ME, Slifker M, Creasy CL, Tummino PJ, Cairns P, Birrer MJ, Zhang R.

Cancer Prev Res (Phila). 2012 Mar;5(3):484-91. doi: 10.1158/1940-6207.CAPR-11-0414. Epub 2011 Dec 5.


Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation.

Herrera B, van Dinther M, Ten Dijke P, Inman GJ.

Cancer Res. 2009 Dec 15;69(24):9254-62. doi: 10.1158/0008-5472.CAN-09-2912. Epub .


Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer.

Chan MW, Huang YW, Hartman-Frey C, Kuo CT, Deatherage D, Qin H, Cheng AS, Yan PS, Davuluri RV, Huang TH, Nephew KP, Lin HJ.

Neoplasia. 2008 Sep;10(9):908-19.


Gene expression of the lysophosphatidic acid receptor 1 is a target of transforming growth factor beta.

Wu J, Mukherjee A, Lebman DA, Fang X.

Oncogene. 2013 Jun 27;32(26):3198-206. doi: 10.1038/onc.2012.325. Epub 2012 Jul 23.


Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta.

Jazag A, Ijichi H, Kanai F, Imamura T, Guleng B, Ohta M, Imamura J, Tanaka Y, Tateishi K, Ikenoue T, Kawakami T, Arakawa Y, Miyagishi M, Taira K, Kawabe T, Omata M.

Oncogene. 2005 Jan 20;24(4):662-71.


A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.

Cell Res. 2014 Aug;24(8):994-1008. doi: 10.1038/cr.2014.97. Epub 2014 Jul 25.


Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice.

Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y.

Development. 2013 Mar;140(6):1220-30. doi: 10.1242/dev.089615. Epub 2013 Feb 13.


Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 protein.

Yang H, Li G, Wu JJ, Wang L, Uhler M, Simeone DM.

J Biol Chem. 2013 Mar 22;288(12):8737-49. doi: 10.1074/jbc.M113.455675. Epub 2013 Jan 28.


Promoter-wide analysis of Smad4 binding sites in human epithelial cells.

Koinuma D, Tsutsumi S, Kamimura N, Imamura T, Aburatani H, Miyazono K.

Cancer Sci. 2009 Nov;100(11):2133-42. doi: 10.1111/j.1349-7006.2009.01299.x. Epub 2009 Jul 23.


Transforming growth factor-β/SMAD Target gene SKIL is negatively regulated by the transcriptional cofactor complex SNON-SMAD4.

Tecalco-Cruz AC, Sosa-Garrocho M, Vázquez-Victorio G, Ortiz-García L, Domínguez-Hüttinger E, Macías-Silva M.

J Biol Chem. 2012 Aug 3;287(32):26764-76. doi: 10.1074/jbc.M112.386599. Epub 2012 Jun 6.


Anomalies of the TGF-beta postreceptor signaling pathway in ovarian cancer cell lines.

Hu W, Wu W, Nash MA, Freedman RS, Kavanagh JJ, Verschraegen CF.

Anticancer Res. 2000 Mar-Apr;20(2A):729-33.


Dysregulation of the TGF-beta postreceptor signaling pathway in cell lines derived from primary or metastatic ovarian cancer.

Xi L, Hu W, Meng L, Zhou J, Lu Y, Wang C, Ma D.

J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):62-5.

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