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Items: 1 to 20 of 192

1.

Phosphodiesterase 5 inhibition attenuates cerebral vasospasm and improves functional recovery after experimental subarachnoid hemorrhage.

Han BH, Vellimana AK, Zhou ML, Milner E, Zipfel GJ.

Neurosurgery. 2012 Jan;70(1):178-86; discussion 186-7. doi: 10.1227/NEU.0b013e31822ec2b0.

2.

Systemic administration of phosphodiesterase V inhibitor, sildenafil citrate, for attenuation of cerebral vasospasm after experimental subarachnoid hemorrhage.

Atalay B, Caner H, Cekinmez M, Ozen O, Celasun B, Altinors N.

Neurosurgery. 2006 Nov;59(5):1102-7; discussion 1107-8.

PMID:
17143244
3.

Type V phosphodiesterase expression in cerebral arteries with vasospasm after subarachnoid hemorrhage in a canine model.

Inoha S, Inamura T, Ikezaki K, Nakamizo A, Amano T, Fukui M.

Neurol Res. 2002 Sep;24(6):607-12.

PMID:
12238630
4.

A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage.

Washington CW, Derdeyn CP, Dhar R, Arias EJ, Chicoine MR, Cross DT, Dacey RG Jr, Han BH, Moran CJ, Rich KM, Vellimana AK, Zipfel GJ.

J Neurosurg. 2016 Feb;124(2):318-27. doi: 10.3171/2015.2.JNS142752. Epub 2015 Aug 28.

PMID:
26314998
5.

The effect of the sildenafil citrate on cerebral vasospasm and apoptosis following experimental subarachnoid hemorrhage in rats.

Gokce C, Gulsen S, Yilmaz C, Guven G, Caner H, Altinors N.

J Neurosurg Sci. 2010 Mar;54(1):29-37.

PMID:
20436396
6.

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats.

Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, Zhang L, Chopp M.

Stroke. 2002 Nov;33(11):2675-80.

7.

Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice.

Wang L, Chopp M, Szalad A, Liu Z, Bolz M, Alvarez FM, Lu M, Zhang L, Cui Y, Zhang RL, Zhang ZG.

Neuroscience. 2011 Oct 13;193:399-410. doi: 10.1016/j.neuroscience.2011.07.039. Epub 2011 Jul 27.

8.

Sildenafil improves epicenter vascular perfusion but not hindlimb functional recovery after contusive spinal cord injury in mice.

Myers SA, DeVries WH, Gruenthal MJ, Andres KR, Hagg T, Whittemore SR.

J Neurotrauma. 2012 Feb 10;29(3):528-38. doi: 10.1089/neu.2011.2036. Epub 2011 Dec 15.

9.

2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats.

Yan J, Chen C, Lei J, Yang L, Wang K, Liu J, Zhou C.

Exp Neurol. 2006 Dec;202(2):348-56. Epub 2006 Aug 10.

PMID:
16904108
10.

Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.

McGirt MJ, Lynch JR, Parra A, Sheng H, Pearlstein RD, Laskowitz DT, Pelligrino DA, Warner DS.

Stroke. 2002 Dec;33(12):2950-6.

11.

Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not.

Mietens A, Tasch S, Feuerstacke C, Eichner G, Volkmann J, Schermuly RT, Grimminger F, Müller D, Middendorff R.

Mol Cell Endocrinol. 2012 Feb 26;349(2):145-53. doi: 10.1016/j.mce.2011.09.039. Epub 2011 Oct 2.

PMID:
21996373
12.

Gender-specific immunological effects of the phosphodiesterase 5 inhibitor sildenafil in healthy mice.

Karakhanova S, Yang Y, Link J, Soltek S, von Ahn K, Umansky V, Werner J, Bazhin AV.

Mol Immunol. 2013 Dec;56(4):649-59. doi: 10.1016/j.molimm.2013.06.021. Epub 2013 Aug 2.

PMID:
23911424
13.

Multifaceted effects of selective inhibitor of phosphodiesterase III, cilostazol, for cerebral vasospasm after subarachnoid hemorrhage in a dog model.

Yamaguchi-Okada M, Nishizawa S, Mizutani A, Namba H.

Cerebrovasc Dis. 2009;28(2):135-42. doi: 10.1159/000223439. Epub 2009 Jun 5.

PMID:
19506373
14.

Monoclonal antibody against E selectin attenuates subarachnoid hemorrhage-induced cerebral vasospasm.

Lin CL, Dumont AS, Calisaneller T, Kwan AL, Hwong SL, Lee KS.

Surg Neurol. 2005 Sep;64(3):201-5; discussion 205-6.

PMID:
16099244
15.

Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke.

Zhang L, Zhang Z, Zhang RL, Cui Y, LaPointe MC, Silver B, Chopp M.

Brain Res. 2006 Nov 6;1118(1):192-8. Epub 2006 Sep 7.

PMID:
16959227
16.

Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.

Choi DE, Jeong JY, Lim BJ, Chung S, Chang YK, Lee SJ, Na KR, Kim SY, Shin YT, Lee KW.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F362-70. doi: 10.1152/ajprenal.90609.2008. Epub 2009 May 27.

17.

Effects of a nitric oxide donor on and correlation of changes in cyclic nucleotide levels with experimental vasospasm.

Aihara Y, Jahromi BS, Yassari R, Sayama T, Macdonald RL.

Neurosurgery. 2003 Mar;52(3):661-7; discussion 666-7.

PMID:
12590692
18.

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice.

Zhang J, Guo J, Zhao X, Chen Z, Wang G, Liu A, Wang Q, Zhou W, Xu Y, Wang C.

Behav Brain Res. 2013 Aug 1;250:230-7. doi: 10.1016/j.bbr.2013.05.017. Epub 2013 May 16.

PMID:
23685322
19.

Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits.

Kwan AL, Lin CL, Chang CZ, Winardi D, Yen CP, Wu SC, Lee KS, Kassell NF, Howng SL, Savage P, Jeng AY.

Clin Sci (Lond). 2002 Aug;103 Suppl 48:414S-417S.

PMID:
12193135
20.

Effect of sildenafil, a selective phosphodiesterase 5 inhibitor, on the anticonvulsant action of some antiepileptic drugs in the mouse 6-Hz psychomotor seizure model.

Nieoczym D, Socała K, Jedziniak P, Olejnik M, Wlaź P.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2;47:104-10. doi: 10.1016/j.pnpbp.2013.08.009. Epub 2013 Aug 30.

PMID:
23994662
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