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Items: 1 to 20 of 103

1.

Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.

Lamberto GR, Torres-Monserrat V, Bertoncini CW, Salvatella X, Zweckstetter M, Griesinger C, Fernández CO.

J Biol Chem. 2011 Sep 16;286(37):32036-44. doi: 10.1074/jbc.M111.242958. Epub 2011 Jul 27.

2.

Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein.

Lee EN, Cho HJ, Lee CH, Lee D, Chung KC, Paik SR.

Biochemistry. 2004 Mar 30;43(12):3704-15.

PMID:
15035641
3.

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation.

Lamberto GR, Binolfi A, Orcellet ML, Bertoncini CW, Zweckstetter M, Griesinger C, Fernández CO.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21057-62. doi: 10.1073/pnas.0902603106. Epub 2009 Nov 30.

4.

Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.

Bhak G, Choe YJ, Paik SR.

BMB Rep. 2009 Sep 30;42(9):541-51. Review.

PMID:
19788854
5.

Characterization of fibrillation process of alpha-synuclein at the initial stage.

Tashiro M, Kojima M, Kihara H, Kasai K, Kamiyoshihara T, Uéda K, Shimotakahara S.

Biochem Biophys Res Commun. 2008 May 9;369(3):910-4. doi: 10.1016/j.bbrc.2008.02.127. Epub 2008 Mar 7.

PMID:
18329380
6.

Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.

Binolfi A, Rodriguez EE, Valensin D, D'Amelio N, Ippoliti E, Obal G, Duran R, Magistrato A, Pritsch O, Zweckstetter M, Valensin G, Carloni P, Quintanar L, Griesinger C, Fernández CO.

Inorg Chem. 2010 Nov 15;49(22):10668-79. doi: 10.1021/ic1016752. Epub 2010 Oct 22.

PMID:
20964419
7.

The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.

Falsone SF, Kungl AJ, Rek A, Cappai R, Zangger K.

J Biol Chem. 2009 Nov 6;284(45):31190-9. doi: 10.1074/jbc.M109.057240. Epub 2009 Sep 15.

8.

Mechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescence.

Kang L, Janowska MK, Moriarty GM, Baum J.

PLoS One. 2013 Sep 18;8(9):e75018. doi: 10.1371/journal.pone.0075018. eCollection 2013.

9.

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation.

Valiente-Gabioud AA, Miotto MC, Chesta ME, Lombardo V, Binolfi A, Fernández CO.

Acc Chem Res. 2016 May 17;49(5):801-8. doi: 10.1021/acs.accounts.5b00507. Epub 2016 May 2.

PMID:
27136297
10.

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation.

van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW.

J Mol Biol. 2010 Jan 22;395(3):627-42. doi: 10.1016/j.jmb.2009.10.066. Epub 2009 Nov 3.

PMID:
19891973
11.

Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.

Masuda M, Hasegawa M, Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M.

FEBS Lett. 2009 Feb 18;583(4):787-91. doi: 10.1016/j.febslet.2009.01.037. Epub 2009 Feb 4.

12.

On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.

Lendel C, Bertoncini CW, Cremades N, Waudby CA, Vendruscolo M, Dobson CM, Schenk D, Christodoulou J, Toth G.

Biochemistry. 2009 Sep 8;48(35):8322-34. doi: 10.1021/bi901285x.

PMID:
19645507
13.

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation.

Falsone SF, Leitinger G, Karner A, Kungl AJ, Kosol S, Cappai R, Zangger K.

Biochim Biophys Acta. 2011 May;1814(5):553-61. doi: 10.1016/j.bbapap.2011.02.008. Epub 2011 Mar 2.

14.

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.

Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9831-6. Epub 2003 Aug 4.

15.

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Nors Perdersen M, Foderà V, Horvath I, van Maarschalkerweerd A, Nørgaard Toft K, Weise C, Almqvist F, Wolf-Watz M, Wittung-Stafshede P, Vestergaard B.

Sci Rep. 2015 May 28;5:10422. doi: 10.1038/srep10422. Erratum in: Sci Rep. 2015;5:15692.

16.

Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils.

Madine J, Clayton JC, Yates EA, Middleton DA.

Org Biomol Chem. 2009 Jun 7;7(11):2414-20. doi: 10.1039/b820808e. Epub 2009 Mar 31.

PMID:
19462052
17.

Structures behind the amyloid aggregation of α-synuclein: an NMR based approach.

Orcellet ML, Fernández CO.

Curr Protein Pept Sci. 2011 May;12(3):188-204. Review.

PMID:
21348834
18.

Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress.

Bhak G, Lee JH, Hahn JS, Paik SR.

PLoS One. 2009;4(1):e4177. doi: 10.1371/journal.pone.0004177. Epub 2009 Jan 12.

19.

Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein.

Cho MK, Kim HY, Fernandez CO, Becker S, Zweckstetter M.

Protein Sci. 2011 Feb;20(2):387-95. doi: 10.1002/pro.570.

20.

Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation.

Torres-Bugeau CM, Ávila CL, Raisman-Vozari R, Papy-Garcia D, Itri R, Barbosa LR, Cortez LM, Sim VL, Chehín RN.

J Biol Chem. 2012 Jan 20;287(4):2398-409. doi: 10.1074/jbc.M111.303503. Epub 2011 Dec 1.

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