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Items: 1 to 20 of 209


Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels.

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA.

J Biol Chem. 2011 Sep 23;286(38):33641-51. doi: 10.1074/jbc.M111.282509. Epub 2011 Jul 27.


Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels.

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA.

J Biol Chem. 2012 Aug 31;287(36):30719-28. doi: 10.1074/jbc.M112.370742. Epub 2012 Jul 2.


Mapping of scorpion toxin receptor sites at voltage-gated sodium channels.

Gurevitz M.

Toxicon. 2012 Sep 15;60(4):502-11. doi: 10.1016/j.toxicon.2012.03.022. Epub 2012 Apr 4.


Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

Cestèle S, Yarov-Yarovoy V, Qu Y, Sampieri F, Scheuer T, Catterall WA.

J Biol Chem. 2006 Jul 28;281(30):21332-44. Epub 2006 May 4.


Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.

Mantegazza M, Cestèle S.

J Physiol. 2005 Oct 1;568(Pt 1):13-30. Epub 2005 Jul 14.


Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor.

Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15426-31. doi: 10.1073/pnas.1112320108. Epub 2011 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3645.


NMR analysis of interaction of LqhalphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel.

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J.

Biochemistry. 2008 Jan 22;47(3):911-21. Epub 2007 Dec 23.


Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin.

Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, Gurevitz M, Goldin AL, Dong K.

J Biol Chem. 2011 May 6;286(18):15781-8. doi: 10.1074/jbc.M110.217000. Epub 2011 Mar 15.


Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels.

Karbat I, Ilan N, Zhang JZ, Cohen L, Kahn R, Benveniste M, Scheuer T, Catterall WA, Gordon D, Gurevitz M.

J Biol Chem. 2010 Oct 1;285(40):30531-8. doi: 10.1074/jbc.M110.150888. Epub 2010 Aug 3.


Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxin.

Cestèle S, Scheuer T, Mantegazza M, Rochat H, Catterall WA.

J Gen Physiol. 2001 Sep;118(3):291-302.


Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

Cestèle S, Qu Y, Rogers JC, Rochat H, Scheuer T, Catterall WA.

Neuron. 1998 Oct;21(4):919-31.


Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.

Gur M, Kahn R, Karbat I, Regev N, Wang J, Catterall WA, Gordon D, Gurevitz M.

J Biol Chem. 2011 Oct 7;286(40):35209-17. doi: 10.1074/jbc.M111.259507. Epub 2011 Aug 8.


Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels.

Karbat I, Cohen L, Gilles N, Gordon D, Gurevitz M.

FASEB J. 2004 Apr;18(6):683-9. Erratum in: FASEB J. 2004 Jun;18(9):following 947.


Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes.

Leipold E, Borges A, Heinemann SH.

J Gen Physiol. 2012 Apr;139(4):305-19. doi: 10.1085/jgp.201110720.


Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels.

Cohen L, Karbat I, Gilles N, Ilan N, Benveniste M, Gordon D, Gurevitz M.

J Biol Chem. 2005 Feb 11;280(6):5045-53. Epub 2004 Nov 29.


Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.

Sokolov S, Kraus RL, Scheuer T, Catterall WA.

Mol Pharmacol. 2008 Mar;73(3):1020-8. Epub 2007 Dec 21.


Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels.

Corzo G, Sabo JK, Bosmans F, Billen B, Villegas E, Tytgat J, Norton RS.

J Biol Chem. 2007 Feb 16;282(7):4643-52. Epub 2006 Dec 5.


Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins.

Kahn R, Karbat I, Ilan N, Cohen L, Sokolov S, Catterall WA, Gordon D, Gurevitz M.

J Biol Chem. 2009 Jul 31;284(31):20684-91. doi: 10.1074/jbc.M109.021303. Epub 2009 Jun 9.


Isolation and characterization of two novel scorpion toxins: The alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.

Vandendriessche T, Olamendi-Portugal T, Zamudio FZ, Possani LD, Tytgat J.

Toxicon. 2010 Sep 15;56(4):613-23. doi: 10.1016/j.toxicon.2010.06.008. Epub 2010 Jun 19.

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