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Items: 1 to 20 of 106

1.

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.

Cardinale D, Guaitoli G, Tondi D, Luciani R, Henrich S, Salo-Ahen OM, Ferrari S, Marverti G, Guerrieri D, Ligabue A, Frassineti C, Pozzi C, Mangani S, Fessas D, Guerrini R, Ponterini G, Wade RC, Costi MP.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E542-9. doi: 10.1073/pnas.1104829108. Epub 2011 Jul 27. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16133.

2.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Pelà M, Saxena P, Luciani R, Santucci M, Ferrari S, Marverti G, Marraccini C, Martello A, Pirondi S, Genovese F, Salvadori S, D'Arca D, Ponterini G, Costi MP, Guerrini R.

J Med Chem. 2014 Feb 27;57(4):1355-67. doi: 10.1021/jm401574p. Epub 2014 Feb 12.

PMID:
24450514
4.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Phan J, Steadman DJ, Koli S, Ding WC, Minor W, Dunlap RB, Berger SH, Lebioda L.

J Biol Chem. 2001 Apr 27;276(17):14170-7. Epub 2001 Jan 24.

5.

Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.

Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP.

J Med Chem. 2012 Nov 26;55(22):10272-6. doi: 10.1021/jm300850v. Epub 2012 Nov 5.

PMID:
23075414
6.

Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.

Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP.

J Med Chem. 2015 Jan 22;58(2):1012-8. doi: 10.1021/jm5011176. Epub 2014 Dec 29.

PMID:
25427005
7.

The active-inactive transition of human thymidylate synthase: targeted molecular dynamics simulations.

Salo-Ahen OM, Wade RC.

Proteins. 2011 Oct;79(10):2886-99. doi: 10.1002/prot.23123. Epub 2011 Aug 22.

PMID:
21905113
8.

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC.

J Med Chem. 2015 Apr 23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1.

PMID:
25798950
9.

Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase.

Berger SH, Berger FG, Lebioda L.

Biochim Biophys Acta. 2004 Jan 14;1696(1):15-22. Review.

PMID:
14726200
10.

The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.

Anderson AC, Perry KM, Freymann DM, Stroud RM.

J Mol Biol. 2000 Mar 31;297(3):645-57.

PMID:
10731418
11.

Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.

Lovelace LL, Gibson LM, Lebioda L.

Biochemistry. 2007 Mar 13;46(10):2823-30. Epub 2007 Feb 13.

12.

Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.

Marverti G, Ligabue A, Paglietti G, Corona P, Piras S, Vitale G, Guerrieri D, Luciani R, Costi MP, Frassineti C, Moruzzi MS.

Eur J Pharmacol. 2009 Aug 1;615(1-3):17-26. doi: 10.1016/j.ejphar.2009.04.062. Epub 2009 May 14.

PMID:
19446547
13.

Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.

Sayre PH, Finer-Moore JS, Fritz TA, Biermann D, Gates SB, MacKellar WC, Patel VF, Stroud RM.

J Mol Biol. 2001 Nov 2;313(4):813-29. Erratum in: J Mol Biol 2002 Mar 1;316(4):1005.

PMID:
11697906
14.

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Ferrari S, Calò S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP.

J Med Chem. 2013 Nov 27;56(22):9356-60. doi: 10.1021/jm4014086. Epub 2013 Nov 13.

PMID:
24147825
16.
17.

Structure-based studies on species-specific inhibition of thymidylate synthase.

Costi MP, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Soragni F, Venturelli A, Stroud RM.

Biochim Biophys Acta. 2002 Jul 18;1587(2-3):206-14. Review.

18.
19.

Internalization and stability of a thymidylate synthase Peptide inhibitor in ovarian cancer cells.

Cannazza G, Cazzato AS, Marraccini C, Pavesi G, Pirondi S, Guerrini R, Pelà M, Frassineti C, Ferrari S, Marverti G, Ponterini G, Costi MP.

J Med Chem. 2014 Dec 26;57(24):10551-6. doi: 10.1021/jm501397h. Epub 2014 Dec 3.

PMID:
25353379
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