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Items: 1 to 20 of 180

1.

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.

Kannaiyan R, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G.

Apoptosis. 2011 Oct;16(10):1028-41. doi: 10.1007/s10495-011-0629-6.

PMID:
21786165
3.

Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways.

Mou H, Zheng Y, Zhao P, Bao H, Fang W, Xu N.

Toxicol In Vitro. 2011 Aug;25(5):1027-32. doi: 10.1016/j.tiv.2011.03.023. Epub 2011 Apr 3.

PMID:
21466843
4.

Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling.

Lee JH, Won YS, Park KH, Lee MK, Tachibana H, Yamada K, Seo KI.

Apoptosis. 2012 Dec;17(12):1275-86. doi: 10.1007/s10495-012-0767-5.

PMID:
23065091
6.

A synthetic naringenin derivative, 5-hydroxy-7,4'-diacetyloxyflavanone-N-phenyl hydrazone (N101-43), induces apoptosis through up-regulation of Fas/FasL expression and inhibition of PI3K/Akt signaling pathways in non-small-cell lung cancer cells.

Bak Y, Kim H, Kang JW, Lee DH, Kim MS, Park YS, Kim JH, Jung KY, Lim Y, Hong J, Yoon DY.

J Agric Food Chem. 2011 Sep 28;59(18):10286-97. doi: 10.1021/jf2017594. Epub 2011 Sep 6.

PMID:
21877710
7.

PDCD6 additively cooperates with anti-cancer drugs through activation of NF-κB pathways.

Park SH, Lee JH, Lee GB, Byun HJ, Kim BR, Park CY, Kim HB, Rho SB.

Cell Signal. 2012 Mar;24(3):726-33. doi: 10.1016/j.cellsig.2011.11.006. Epub 2011 Nov 12.

PMID:
22142513
8.
9.

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY.

Mol Cancer Ther. 2007 Jul;6(7):2029-38. Epub 2007 Jun 29.

10.

Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells.

Qu Y, Wang J, Sim MS, Liu B, Giuliano A, Barsoum J, Cui X.

Breast Cancer Res Treat. 2010 Jun;121(2):311-21. doi: 10.1007/s10549-009-0470-6. Epub 2009 Jul 16.

PMID:
19609669
11.

Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network.

Chen S, Gu C, Xu C, Zhang J, Xu Y, Ren Q, Guo M, Huang S, Chen L.

J Neurochem. 2014 Jan;128(2):256-66. doi: 10.1111/jnc.12474. Epub 2013 Oct 24.

12.

Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125.

Wang B, Tsukada J, Higashi T, Mizobe T, Matsuura A, Mouri F, Sawamukai N, Ra C, Tanaka Y.

Genes Cells. 2006 Sep;11(9):983-92.

13.

Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.

Eur J Pharmacol. 2007 Jun 1;563(1-3):49-60. Epub 2007 Feb 8.

PMID:
17341418
14.

TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways.

Rivas MA, Carnevale RP, Proietti CJ, Rosemblit C, Beguelin W, Salatino M, Charreau EH, Frahm I, Sapia S, Brouckaert P, Elizalde PV, Schillaci R.

Exp Cell Res. 2008 Feb 1;314(3):509-29. Epub 2007 Oct 13.

PMID:
18061162
15.

[Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line].

Wang XN, Wu Q, Yang X.

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Feb;31(2):228-32. Chinese.

PMID:
21425580
16.

Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL.

Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou YS, Kuo WH.

Arch Toxicol. 2007 Oct;81(10):719-28. Epub 2007 Aug 3.

PMID:
17673978
17.

Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.

Beales IL, Ogunwobi O.

Mol Cell Endocrinol. 2006 Mar 9;247(1-2):140-9. Epub 2006 Jan 27.

PMID:
16442704
18.

Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.

Moon DO, Lee KJ, Choi YH, Kim GY.

Int Immunopharmacol. 2007 Aug;7(8):1044-53. Epub 2007 Apr 26.

PMID:
17570321
20.

Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis.

Liou SF, Lin HH, Liang JC, Chen IJ, Yeh JL.

Toxicology. 2009 Feb 4;256(1-2):13-24. doi: 10.1016/j.tox.2008.10.025. Epub 2008 Nov 14.

PMID:
19056458
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