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Results: 1 to 20 of 83

1.

Raf family kinases: old dogs have learned new tricks.

Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W.

Genes Cancer. 2011 Mar;2(3):232-60. doi: 10.1177/1947601911407323.

PMID:
21779496
[PubMed]
Free PMC Article
2.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
[PubMed - indexed for MEDLINE]
3.

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Roberts PJ, Der CJ.

Oncogene. 2007 May 14;26(22):3291-310. Review.

PMID:
17496923
[PubMed - indexed for MEDLINE]
4.

ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.

Galabova-Kovacs G, Kolbus A, Matzen D, Meissl K, Piazzolla D, Rubiolo C, Steinitz K, Baccarini M.

Cell Cycle. 2006 Jul;5(14):1514-8. Epub 2006 Jul 17. Review.

PMID:
16861903
[PubMed - indexed for MEDLINE]
Free Article
5.

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF.

Recent Prog Horm Res. 2001;56:127-55. Review.

PMID:
11237210
[PubMed - indexed for MEDLINE]
6.

Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo.

O'Neill E, Kolch W.

Cell Cycle. 2005 Mar;4(3):365-7. Epub 2005 Mar 8. Review.

PMID:
15701972
[PubMed - indexed for MEDLINE]
Free Article
7.

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, Franklin RA, McCubrey JA.

Leukemia. 2003 Jul;17(7):1263-93. Review.

PMID:
12835716
[PubMed - indexed for MEDLINE]
8.

Oncogenic B-Raf mutations: crystal clear at last.

Dhillon AS, Kolch W.

Cancer Cell. 2004 Apr;5(4):303-4.

PMID:
15093535
[PubMed - indexed for MEDLINE]
9.

Therapeutic strategies for targeting ras proteins.

Gysin S, Salt M, Young A, McCormick F.

Genes Cancer. 2011 Mar;2(3):359-72. doi: 10.1177/1947601911412376.

PMID:
21779505
[PubMed]
Free PMC Article
10.

Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.

Gollob JA, Wilhelm S, Carter C, Kelley SL.

Semin Oncol. 2006 Aug;33(4):392-406. Review.

PMID:
16890795
[PubMed - indexed for MEDLINE]
11.

Discovery of a novel Raf kinase inhibitor.

Lyons JF, Wilhelm S, Hibner B, Bollag G.

Endocr Relat Cancer. 2001 Sep;8(3):219-25. Review.

PMID:
11566613
[PubMed - indexed for MEDLINE]
Free Article
12.

RAS/RAF/MEK inhibitors in oncology.

Rusconi P, Caiola E, Broggini M.

Curr Med Chem. 2012;19(8):1164-76. Review.

PMID:
22257058
[PubMed - indexed for MEDLINE]
13.

Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells.

Subramanian RR, Yamakawa A.

Int J Oncol. 2012 Nov;41(5):1855-62. doi: 10.3892/ijo.2012.1602. Epub 2012 Aug 22.

PMID:
22922669
[PubMed - indexed for MEDLINE]
14.

Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway.

Wong KK.

Recent Pat Anticancer Drug Discov. 2009 Jan;4(1):28-35. Review.

PMID:
19149686
[PubMed - indexed for MEDLINE]
16.

Raf: a strategic target for therapeutic development against cancer.

Beeram M, Patnaik A, Rowinsky EK.

J Clin Oncol. 2005 Sep 20;23(27):6771-90. Review.

PMID:
16170185
[PubMed - indexed for MEDLINE]
17.

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

Troppmair J, Bruder JT, Munoz H, Lloyd PA, Kyriakis J, Banerjee P, Avruch J, Rapp UR.

J Biol Chem. 1994 Mar 4;269(9):7030-5.

PMID:
8120067
[PubMed - indexed for MEDLINE]
Free Article
18.
19.

Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1.

Kogut MH, Genovese KJ, He H.

Mol Immunol. 2007 Mar;44(7):1729-36. Epub 2006 Oct 12.

PMID:
17045653
[PubMed - indexed for MEDLINE]
20.

Raf kinases in cancer-roles and therapeutic opportunities.

Maurer G, Tarkowski B, Baccarini M.

Oncogene. 2011 Aug 11;30(32):3477-88. doi: 10.1038/onc.2011.160. Epub 2011 May 16. Review.

PMID:
21577205
[PubMed - indexed for MEDLINE]

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