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Results: 1 to 20 of 89

1.

Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism.

Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ.

PPAR Res. 2011;2011:318134. doi: 10.1155/2011/318134. Epub 2011 Jun 16.

PMID:
21765824
[PubMed]
Free PMC Article
2.

Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.

Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L912-9. doi: 10.1152/ajplung.00148.2009. Epub 2009 Sep 4.

PMID:
19734319
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):722-30. doi: 10.1165/rcmb.2009-0006OC. Epub 2009 Mar 13.

PMID:
19286977
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

Cheng S, Afif H, Martel-Pelletier J, Pelletier JP, Li X, Farrajota K, Lavigne M, Fahmi H.

J Biol Chem. 2004 May 21;279(21):22057-65. Epub 2004 Mar 15.

PMID:
15023995
[PubMed - indexed for MEDLINE]
Free Article
5.

15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway.

Boyault S, Bianchi A, Moulin D, Morin S, Francois M, Netter P, Terlain B, Bordji K.

FEBS Lett. 2004 Aug 13;572(1-3):33-40.

PMID:
15304320
[PubMed - indexed for MEDLINE]
6.

Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.

Farrajota K, Cheng S, Martel-Pelletier J, Afif H, Pelletier JP, Li X, Ranger P, Fahmi H.

Arthritis Rheum. 2005 Jan;52(1):94-104.

PMID:
15641079
[PubMed - indexed for MEDLINE]
Free Article
7.
8.

Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism.

Moulin D, Bianchi A, Boyault S, Sebillaud S, Koufany M, Francois M, Netter P, Jouzeau JY, Terlain B.

Arthritis Rheum. 2005 Mar;52(3):759-69.

PMID:
15751073
[PubMed - indexed for MEDLINE]
Free Article
9.

Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages.

Kim HY, Kim HS.

Immunol Cell Biol. 2007 Jan;85(1):60-7. Epub 2006 Nov 28.

PMID:
17130903
[PubMed - indexed for MEDLINE]
10.

Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.

Kuriyan AE, Lehmann GM, Kulkarni AA, Woeller CF, Feldon SE, Hindman HB, Sime PJ, Huxlin KR, Phipps RP.

Exp Eye Res. 2012 Jan;94(1):136-45. doi: 10.1016/j.exer.2011.11.018. Epub 2011 Dec 8.

PMID:
22178289
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism.

Reyes-Martin P, Ramirez-Rubio S, Parra-Cid T, Bienes-Martínez R, Lucio-Cazana J.

Pharmacol Res. 2008 May;57(5):344-50. doi: 10.1016/j.phrs.2008.03.007. Epub 2008 Mar 26.

PMID:
18456507
[PubMed - indexed for MEDLINE]
12.

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ.

PLoS One. 2011 Jan 6;6(1):e15909. doi: 10.1371/journal.pone.0015909.

PMID:
21253589
[PubMed - indexed for MEDLINE]
Free PMC Article
13.
14.

The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1.

Jung WK, Park IS, Park SJ, Yea SS, Choi YH, Oh S, Park SG, Choi IW.

Life Sci. 2009 Jul 3;85(1-2):46-53. doi: 10.1016/j.lfs.2009.04.010. Epub 2009 May 3.

PMID:
19409914
[PubMed - indexed for MEDLINE]
15.
17.
18.

15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.

Liu X, Yu H, Yang L, Li C, Li L.

Eur J Cell Biol. 2012 Aug;91(8):654-61. doi: 10.1016/j.ejcb.2012.03.004. Epub 2012 May 4.

PMID:
22560326
[PubMed - indexed for MEDLINE]
20.

15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells.

Sawano H, Haneda M, Sugimoto T, Inoki K, Koya D, Kikkawa R.

Kidney Int. 2002 Jun;61(6):1957-67.

PMID:
12028436
[PubMed - indexed for MEDLINE]
Free Article
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