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The development and description of the comparison group in the Look AHEAD trial.

Wesche-Thobaben JA.

Clin Trials. 2011 Jun;8(3):320-9. doi: 10.1177/1740774511405858.


Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes.

Ryan DH, Espeland MA, Foster GD, Haffner SM, Hubbard VS, Johnson KC, Kahn SE, Knowler WC, Yanovski SZ; Look AHEAD Research Group.

Control Clin Trials. 2003 Oct;24(5):610-28.


The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it.

Look AHEAD Research Group, Wadden TA, West DS, Delahanty L, Jakicic J, Rejeski J, Williamson D, Berkowitz RI, Kelley DE, Tomchee C, Hill JO, Kumanyika S.

Obesity (Silver Spring). 2006 May;14(5):737-52. Review. Erratum in: Obesity (Silver Spring). 2007 May;15(5):1339. Wadden, Thomas A [added]; West, Delia Smith [added]; Delahanty, Linda [added]; Jakicic, John [added]; Rejeski, Jack [added]; Williamson, Don [added]; Berkowitz, Robert I [added]; Kelley, David E [added]; Tomchee, Christine [added]; Hill, James O [added]; Kumanyika, Shiriki [added].


Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study.

Look Ahead Research Group, Bray G, Gregg E, Haffner S, Pi-Sunyer XF, WagenKnecht LE, Walkup M, Wing R.

Diab Vasc Dis Res. 2006 Dec;3(3):202-15.


Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study.

Jakicic JM, Jaramillo SA, Balasubramanyam A, Bancroft B, Curtis JM, Mathews A, Pereira M, Regensteiner JG, Ribisl PM; Look AHEAD Study Group.

Int J Obes (Lond). 2009 Mar;33(3):305-16. doi: 10.1038/ijo.2008.280. Epub 2009 Jan 20.


Partial Meal Replacement Plan and Quality of the Diet at 1 Year: Action for Health in Diabetes (Look AHEAD) Trial.

Raynor HA, Anderson AM, Miller GD, Reeves R, Delahanty LM, Vitolins MZ, Harper P, Mobley C, Konersman K, Mayer-Davis E; Look AHEAD Research Group.

J Acad Nutr Diet. 2015 May;115(5):731-42. doi: 10.1016/j.jand.2014.11.003. Epub 2015 Jan 6.


Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: results from the Look AHEAD trial.

Breyer BN, Phelan S, Hogan PE, Rosen RC, Kitabchi AE, Wing RR, Brown JS; Look AHEAD Research Group.

J Urol. 2014 Jul;192(1):144-9. doi: 10.1016/j.juro.2014.02.036. Epub 2014 Feb 14.


Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.

Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitabchi AE, Knowler WC, Lewis CE, Maschak-Carey BJ, Montez MG, Murillo A, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Reboussin D, Regensteiner JG, Rickman AD, Ryan DH, Safford M, Wadden TA, Wagenknecht LE, West DS, Williamson DF, Yanovski SZ.

N Engl J Med. 2013 Jul 11;369(2):145-54. doi: 10.1056/NEJMoa1212914. Epub 2013 Jun 24. Erratum in: N Engl J Med. 2014 May 8;370(19):1866.


Fiber intake and plasminogen activator inhibitor-1 in type 2 diabetes: Look AHEAD (Action for Health in Diabetes) trial findings at baseline and year 1.

Belalcazar LM, Anderson AM, Lang W, Schwenke DC, Haffner SM, Yatsuya H, Rushing J, Vitolins MZ, Reeves R, Pi-Sunyer FX, Tracy RP, Ballantyne CM; Look AHEAD (Action for Health in Diabetes) Research Group.

J Acad Nutr Diet. 2014 Nov;114(11):1800-10.e2. doi: 10.1016/j.jand.2014.06.357. Epub 2014 Aug 15.


Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial.

Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS; Look AHEAD Research Group.

J Urol. 2012 Mar;187(3):939-44. doi: 10.1016/j.juro.2011.10.139. Epub 2012 Jan 20.


The results of Look AHEAD do not row against the implementation of lifestyle changes in patients with type 2 diabetes.

Annuzzi G, Rivellese AA, Bozzetto L, Riccardi G.

Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):4-9. doi: 10.1016/j.numecd.2013.12.001. Epub 2013 Dec 20.


Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study.

Gibbs BB, Brancati FL, Chen H, Coday M, Jakicic JM, Lewis CE, Stewart KJ, Clark JM; (for the Look AHEAD Research Group).

Eur J Prev Cardiol. 2014 May;21(5):608-17. doi: 10.1177/2047487312462823. Epub 2012 Sep 25.


Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial.

Look AHEAD Research Group, Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM, Curtis JM, Espeland MA, Foreyt JP, Graves K, Haffner SM, Harrison B, Hill JO, Horton ES, Jakicic J, Jeffery RW, Johnson KC, Kahn S, Kelley DE, Kitabchi AE, Knowler WC, Lewis CE, Maschak-Carey BJ, Montgomery B, Nathan DM, Patricio J, Peters A, Redmon JB, Reeves RS, Ryan DH, Safford M, Van Dorsten B, Wadden TA, Wagenknecht L, Wesche-Thobaben J, Wing RR, Yanovski SZ.

Diabetes Care. 2007 Jun;30(6):1374-83. Epub 2007 Mar 15.


Effect of the look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes.

Redmon JB, Bertoni AG, Connelly S, Feeney PA, Glasser SP, Glick H, Greenway F, Hesson LA, Lawlor MS, Montez M, Montgomery B; Look AHEAD Research Group.

Diabetes Care. 2010 Jun;33(6):1153-8. doi: 10.2337/dc09-2090. Epub 2010 Mar 23.


A long-term intensive lifestyle intervention and physical function: the look AHEAD Movement and Memory Study.

Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB; Action for Health In Diabetes (Look AHEAD) Movement and Memory Ancillary Study Research Group.

Obesity (Silver Spring). 2015 Jan;23(1):77-84. doi: 10.1002/oby.20944. Epub 2014 Nov 29.


Implications of Look AHEAD for clinical trials and clinical practice.

Wing RR; Look AHEAD Research Group.

Diabetes Obes Metab. 2014 Dec;16(12):1183-91. doi: 10.1111/dom.12318. Epub 2014 Jun 22.


Diabetes: Looking back at Look AHEAD--giving lifestyle a chance.

Despr├ęs JP, Poirier P.

Nat Rev Cardiol. 2013 Apr;10(4):184-6. doi: 10.1038/nrcardio.2013.16. Epub 2013 Feb 19.


Cluster randomised controlled trial of a peer-led lifestyle intervention program: study protocol for the Kerala diabetes prevention program.

Sathish T, Williams ED, Pasricha N, Absetz P, Lorgelly P, Wolfe R, Mathews E, Aziz Z, Thankappan KR, Zimmet P, Fisher E, Tapp R, Hollingsworth B, Mahal A, Shaw J, Jolley D, Daivadanam M, Oldenburg B.

BMC Public Health. 2013 Nov 4;13:1035. doi: 10.1186/1471-2458-13-1035.


Structured, intensive education maximising engagement, motivation and long-term change for children and young people with diabetes: a cluster randomised controlled trial with integral process and economic evaluation - the CASCADE study.

Christie D, Thompson R, Sawtell M, Allen E, Cairns J, Smith F, Jamieson E, Hargreaves K, Ingold A, Brooks L, Wiggins M, Oliver S, Jones R, Elbourne D, Santos A, Wong IC, O'Neill S, Strange V, Hindmarsh P, Annan F, Viner R.

Health Technol Assess. 2014 Mar;18(20):1-202. doi: 10.3310/hta18200.

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