Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 171

1.

Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.

Pyle LC, Ehrhardt A, Mitchell LH, Fan L, Ren A, Naren AP, Li Y, Clancy JP, Bolger GB, Sorscher EJ, Rowe SM.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L587-97. doi: 10.1152/ajplung.00465.2010. Epub 2011 Jul 1.

PMID:
21724857
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.

Pasyk S, Li C, Ramjeesingh M, Bear CE.

Biochem J. 2009 Feb 15;418(1):185-90. doi: 10.1042/BJ20081424.

PMID:
18945216
[PubMed - indexed for MEDLINE]
Free Article
3.

Probing conformational rescue induced by a chemical corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutant.

Yu W, Kim Chiaw P, Bear CE.

J Biol Chem. 2011 Jul 15;286(28):24714-25. doi: 10.1074/jbc.M111.239699. Epub 2011 May 21.

PMID:
21602569
[PubMed - indexed for MEDLINE]
Free PMC Article
4.
5.

A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR[delta]F508.

deCarvalho AC, Ndi CP, Tsopmo A, Tane P, Ayafor J, Connolly JD, Teem JL.

Mol Med. 2002 Feb;8(2):75-87.

PMID:
12080183
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Comparison of cystic fibrosis transmembrane conductance regulator (CFTR) and ciliary beat frequency activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures.

Conger BT, Zhang S, Skinner D, Hicks SB, Sorscher EJ, Rowe SM, Woodworth BA.

JAMA Otolaryngol Head Neck Surg. 2013 Aug 1;139(8):822-7. doi: 10.1001/jamaoto.2013.3917. Erratum in: JAMA Otolaryngol Head Neck Surg. 2013 Oct;139(10):1.

PMID:
23949358
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist.

Namkung W, Park J, Seo Y, Verkman AS.

Mol Pharmacol. 2013 Sep;84(3):384-92. doi: 10.1124/mol.113.086348. Epub 2013 Jun 20.

PMID:
23788656
[PubMed - indexed for MEDLINE]
8.

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Cao D, Neuberger T, Turnbull A, Singh A, Joubran J, Hazlewood A, Zhou J, McCartney J, Arumugam V, Decker C, Yang J, Young C, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu P.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30. doi: 10.1073/pnas.0904709106. Epub 2009 Oct 21.

PMID:
19846789
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescue.

Pyle LC, Fulton JC, Sloane PA, Backer K, Mazur M, Prasain J, Barnes S, Clancy JP, Rowe SM.

Am J Respir Cell Mol Biol. 2010 Nov;43(5):607-16. doi: 10.1165/rcmb.2009-0281OC. Epub 2009 Dec 30.

PMID:
20042712
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents by the chemical solvent tetrahydrofuran.

Hughes LK, Ju M, Sheppard DN.

Mol Membr Biol. 2008 Sep;25(6-7):528-38. doi: 10.1080/09687680802487967.

PMID:
18989824
[PubMed - indexed for MEDLINE]
11.

High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening.

Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS.

J Biol Chem. 2002 Oct 4;277(40):37235-41. Epub 2002 Aug 2.

PMID:
12161441
[PubMed - indexed for MEDLINE]
Free Article
12.

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.

Eckford PD, Li C, Ramjeesingh M, Bear CE.

J Biol Chem. 2012 Oct 26;287(44):36639-49. doi: 10.1074/jbc.M112.393637. Epub 2012 Aug 31.

PMID:
22942289
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels.

Wang F, Zeltwanger S, Hu S, Hwang TC.

J Physiol. 2000 May 1;524 Pt 3:637-48.

PMID:
10790148
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Cystic fibrosis transmembrane conductance regulator-modifying medications: the future of cystic fibrosis treatment.

Pettit RS.

Ann Pharmacother. 2012 Jul-Aug;46(7-8):1065-75. doi: 10.1345/aph.1R076. Epub 2012 Jun 26. Review.

PMID:
22739718
[PubMed - indexed for MEDLINE]
15.

Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis.

Derichs N.

Eur Respir Rev. 2013 Mar 1;22(127):58-65. doi: 10.1183/09059180.00008412. Review.

PMID:
23457166
[PubMed - indexed for MEDLINE]
Free Article
16.

Identification of synergistic combinations of F508del cystic fibrosis transmembrane conductance regulator (CFTR) modulators.

Lin S, Sui J, Cotard S, Fung B, Andersen J, Zhu P, El Messadi N, Lehar J, Lee M, Staunton J.

Assay Drug Dev Technol. 2010 Dec;8(6):669-84. doi: 10.1089/adt.2010.0313. Epub 2010 Nov 4.

PMID:
21050065
[PubMed - indexed for MEDLINE]
17.

Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy.

Kim Chiaw P, Eckford PD, Bear CE.

Essays Biochem. 2011 Sep 7;50(1):233-48. doi: 10.1042/bse0500233. Review.

PMID:
21967060
[PubMed - indexed for MEDLINE]
18.

Ivacaftor potentiation of multiple CFTR channels with gating mutations.

Yu H, Burton B, Huang CJ, Worley J, Cao D, Johnson JP Jr, Urrutia A, Joubran J, Seepersaud S, Sussky K, Hoffman BJ, Van Goor F.

J Cyst Fibros. 2012 May;11(3):237-45. doi: 10.1016/j.jcf.2011.12.005. Epub 2012 Jan 30.

PMID:
22293084
[PubMed - indexed for MEDLINE]
Free Article
19.

Ivacaftor: the first therapy acting on the primary cause of cystic fibrosis.

McPhail GL, Clancy JP.

Drugs Today (Barc). 2013 Apr;49(4):253-60. doi: 10.1358/dot.2013.49.4.1940984.

PMID:
23616952
[PubMed - indexed for MEDLINE]
20.

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

Ren HY, Grove DE, De La Rosa O, Houck SA, Sopha P, Van Goor F, Hoffman BJ, Cyr DM.

Mol Biol Cell. 2013 Oct;24(19):3016-24. doi: 10.1091/mbc.E13-05-0240. Epub 2013 Aug 7.

PMID:
23924900
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk