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Results: 1 to 20 of 97

1.

Impact of fusion to Gα(i2) and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB₁R and CB₂R.

Sutor S, Heilmann J, Seifert R.

J Pharm Pharmacol. 2011 Aug;63(8):1043-55. doi: 10.1111/j.2042-7158.2011.01307.x. Epub 2011 Jun 8.

PMID:
21718288
[PubMed - indexed for MEDLINE]
2.

Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands.

Schneider EH, Seifert R.

Biochem Pharmacol. 2009 Sep 15;78(6):607-16. doi: 10.1016/j.bcp.2009.05.015. Epub 2009 May 21.

PMID:
19464266
[PubMed - indexed for MEDLINE]
3.

Fusion proteins as model systems for the analysis of constitutive GPCR activity.

Schneider EH, Seifert R.

Methods Enzymol. 2010;485:459-80. doi: 10.1016/B978-0-12-381296-4.00025-7.

PMID:
21050932
[PubMed - indexed for MEDLINE]
4.

Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands.

Geiger S, Nickl K, Schneider EH, Seifert R, Heilmann J.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Aug;382(2):177-91. doi: 10.1007/s00210-010-0534-5. Epub 2010 Jul 9.

PMID:
20617431
[PubMed - indexed for MEDLINE]
5.

The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.

Cavalli A, Druey KM, Milligan G.

J Biol Chem. 2000 Aug 4;275(31):23693-9.

PMID:
10807934
[PubMed - indexed for MEDLINE]
Free Article
6.

Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled receptors.

Schneider EH, Seifert R.

Pharmacol Ther. 2010 Dec;128(3):387-418. doi: 10.1016/j.pharmthera.2010.07.005. Epub 2010 Aug 10. Review.

PMID:
20705094
[PubMed - indexed for MEDLINE]
7.

Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model.

Clark MJ, Linderman JJ, Traynor JR.

Mol Pharmacol. 2008 May;73(5):1538-48. doi: 10.1124/mol.107.043547. Epub 2008 Feb 19.

PMID:
18285510
[PubMed - indexed for MEDLINE]
Free Article
8.

High constitutive activity and a G-protein-independent high-affinity state of the human histamine H(4)-receptor.

Schneider EH, Schnell D, Papa D, Seifert R.

Biochemistry. 2009 Feb 17;48(6):1424-38. doi: 10.1021/bi802050d.

PMID:
19166345
[PubMed - indexed for MEDLINE]
9.

No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers.

Schnell D, Burleigh K, Trick J, Seifert R.

J Pharmacol Exp Ther. 2010 Mar;332(3):996-1005. doi: 10.1124/jpet.109.162339. Epub 2009 Dec 3.

PMID:
19959746
[PubMed - indexed for MEDLINE]
Free Article
10.

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.

Tang W, Tu Y, Nayak SK, Woodson J, Jehl M, Ross EM.

J Biol Chem. 2006 Feb 24;281(8):4746-53. Epub 2005 Dec 29.

PMID:
16407201
[PubMed - indexed for MEDLINE]
Free Article
11.

Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.

Roman DL, Blazer LL, Monroy CA, Neubig RR.

Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.

PMID:
20530129
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells.

Kleemann P, Papa D, Vigil-Cruz S, Seifert R.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Sep;378(3):261-74. doi: 10.1007/s00210-008-0313-8. Epub 2008 Jun 4.

PMID:
18523757
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Purification and in vitro functional analysis of R7 subfamily RGS proteins in complex with Gbeta5.

Hooks SB, Harden TK.

Methods Enzymol. 2004;390:163-77.

PMID:
15488177
[PubMed - indexed for MEDLINE]
14.

RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling.

Mao H, Zhao Q, Daigle M, Ghahremani MH, Chidiac P, Albert PR.

J Biol Chem. 2004 Jun 18;279(25):26314-22. Epub 2004 Apr 19.

PMID:
15096504
[PubMed - indexed for MEDLINE]
Free Article
15.

Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7.

Lan KL, Zhong H, Nanamori M, Neubig RR.

J Biol Chem. 2000 Oct 27;275(43):33497-503.

PMID:
10942773
[PubMed - indexed for MEDLINE]
Free Article
16.

Analysis of G-protein-coupled receptor kinase RGS homology domains.

Day PW, Wedegaertner PB, Benovic JL.

Methods Enzymol. 2004;390:295-310.

PMID:
15488185
[PubMed - indexed for MEDLINE]
17.

Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP.

J Biol Chem. 2009 Jul 17;284(29):19402-11. doi: 10.1074/jbc.M109.024711. Epub 2009 May 28.

PMID:
19478087
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Ligand screening system using fusion proteins of G protein-coupled receptors with G protein alpha subunits.

Suga H, Haga T.

Neurochem Int. 2007 Jul-Sep;51(2-4):140-64. Epub 2007 Jun 19. Review.

PMID:
17659814
[PubMed - indexed for MEDLINE]
19.

Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.

Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T.

J Biol Chem. 1999 Nov 26;274(48):34483-92.

PMID:
10567430
[PubMed - indexed for MEDLINE]
Free Article
20.

Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling.

Georgoussi Z, Leontiadis L, Mazarakou G, Merkouris M, Hyde K, Hamm H.

Cell Signal. 2006 Jun;18(6):771-82. Epub 2005 Aug 24.

PMID:
16120478
[PubMed - indexed for MEDLINE]

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