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Items: 1 to 20 of 94

1.

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations.

Payne BA, Wilson IJ, Hateley CA, Horvath R, Santibanez-Koref M, Samuels DC, Price DA, Chinnery PF.

Nat Genet. 2011 Jun 26;43(8):806-10. doi: 10.1038/ng.863.

2.

The timing of mitochondrial DNA mutations in aging.

Khrapko K.

Nat Genet. 2011 Jul 27;43(8):726-7. doi: 10.1038/ng.895. No abstract available.

3.

Somatic mitochondrial DNA mutations in mammalian aging.

Larsson NG.

Annu Rev Biochem. 2010;79:683-706. doi: 10.1146/annurev-biochem-060408-093701. Review.

PMID:
20350166
4.

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Greaves LC, Nooteboom M, Elson JL, Tuppen HA, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TB, Mathers JC, Turnbull DM.

PLoS Genet. 2014 Sep 18;10(9):e1004620. doi: 10.1371/journal.pgen.1004620. eCollection 2014 Sep.

5.

Mitochondrial DNA mutations in disease and aging.

Wallace DC.

Environ Mol Mutagen. 2010 Jun;51(5):440-50. doi: 10.1002/em.20586. Review.

PMID:
20544884
6.

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

Elson JL, Samuels DC, Turnbull DM, Chinnery PF.

Am J Hum Genet. 2001 Mar;68(3):802-6. Epub 2001 Feb 6.

7.

Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms.

Coller HA, Bodyak ND, Khrapko K.

Ann N Y Acad Sci. 2002 Apr;959:434-47.

PMID:
11976216
8.

Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA.

Sato A, Nakada K, Hayashi J.

Biochim Biophys Acta. 2006 May-Jun;1763(5-6):473-81. Epub 2006 Mar 24. Review.

9.

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.

Ross JM, Stewart JB, Hagström E, Brené S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson NG.

Nature. 2013 Sep 19;501(7467):412-5. doi: 10.1038/nature12474. Epub 2013 Aug 21.

10.

Mitochondrial DNA mutations in ageing and disease: implications for HIV?

Payne BA, Gardner K, Chinnery PF.

Antivir Ther. 2015;20(2):109-20. doi: 10.3851/IMP2824. Epub 2014 Jul 17. Review.

PMID:
25032944
11.

Mitochondrial DNA mutations associated with aging and degenerative diseases.

Ozawa T.

Exp Gerontol. 1995 May-Aug;30(3-4):269-90. Review.

PMID:
7556507
12.

The role of mitochondria in aging.

Bratic A, Larsson NG.

J Clin Invest. 2013 Mar;123(3):951-7. doi: 10.1172/JCI64125. Epub 2013 Mar 1. Review.

13.

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases.

Ozawa T.

Biochim Biophys Acta. 1995 May 24;1271(1):177-89. Review.

PMID:
7599206
14.

Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.

Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L.

PLoS One. 2014 May 12;9(5):e96940. doi: 10.1371/journal.pone.0096940. eCollection 2014.

15.

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. Epub 2005 Dec 6.

16.

Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.

Tanaka M, Kovalenko SA, Gong JS, Borgeld HJ, Katsumata K, Hayakawa M, Yoneda M, Ozawa T.

Ann N Y Acad Sci. 1996 Jun 15;786:102-11.

PMID:
8687011
17.

Somatic mutations of mitochondrial DNA in aging and cancer progression.

Lee HC, Chang CM, Chi CW.

Ageing Res Rev. 2010 Nov;9 Suppl 1:S47-58. doi: 10.1016/j.arr.2010.08.009. Epub 2010 Sep 8. Review.

PMID:
20816876
18.

Common inherited mitochondrial DNA mutations and nucleoside reverse transcriptase inhibitor-induced severe hyperlactataemia in HIV-infected adults: an exploratory study.

Arenas-Pinto A, Weller I, Ekong R, Grant A, Karstaedt A, Reiss P, Telisinghe L, Weber R, Bolhaar M, Bradman N, Ingram C.

Antivir Ther. 2012;17(2):275-82. doi: 10.3851/IMP1947. Epub 2011 Nov 7. Erratum in: Antivir Ther. 2012;17(6):1103-4.

PMID:
22293466
19.

Mitochondrial DNA mutations in aging.

Khrapko K, Turnbull D.

Prog Mol Biol Transl Sci. 2014;127:29-62. doi: 10.1016/B978-0-12-394625-6.00002-7. Review.

PMID:
25149213
20.

Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

Kadenbach B, Münscher C, Frank V, Müller-Höcker J, Napiwotzki J.

Mutat Res. 1995 Oct;338(1-6):161-72. Review.

PMID:
7565871
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