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Results: 1 to 20 of 102

1.

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design.

Durrant JD, Cao R, Gorfe AA, Zhu W, Li J, Sankovsky A, Oldfield E, McCammon JA.

Chem Biol Drug Des. 2011 Sep;78(3):323-32. doi: 10.1111/j.1747-0285.2011.01164.x. Epub 2011 Aug 3.

PMID:
21696546
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Farnesyl diphosphate synthase inhibitors from in silico screening.

Lindert S, Zhu W, Liu YL, Pang R, Oldfield E, McCammon JA.

Chem Biol Drug Des. 2013 Jun;81(6):742-8. doi: 10.1111/cbdd.12121.

PMID:
23421555
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.

Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G.

Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.

PMID:
10620343
[PubMed - indexed for MEDLINE]
4.

Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads.

Sinko W, Wang Y, Zhu W, Zhang Y, Feixas F, Cox CL, Mitchell DA, Oldfield E, McCammon JA.

J Med Chem. 2014 Jul 10;57(13):5693-701. doi: 10.1021/jm5004649. Epub 2014 Jun 24.

PMID:
24827744
[PubMed - indexed for MEDLINE]
5.

An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases.

Dozier JK, Distefano MD.

Anal Biochem. 2012 Feb 1;421(1):158-63. doi: 10.1016/j.ab.2011.10.038. Epub 2011 Oct 28.

PMID:
22085443
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17.

PMID:
23248302
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.

Aripirala S, Szajnman SH, Jakoncic J, Rodriguez JB, Docampo R, Gabelli SB, Amzel LM.

J Med Chem. 2012 Jul 26;55(14):6445-54. doi: 10.1021/jm300425y. Epub 2012 Jul 5.

PMID:
22715997
[PubMed - indexed for MEDLINE]
8.

Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.

Oldfield E.

Acc Chem Res. 2010 Sep 21;43(9):1216-26. doi: 10.1021/ar100026v.

PMID:
20560544
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.

Thompson K, Dunford JE, Ebetino FH, Rogers MJ.

Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73.

PMID:
11785983
[PubMed - indexed for MEDLINE]
10.

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ.

J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.

PMID:
11160603
[PubMed - indexed for MEDLINE]
Free Article
11.

Synthesis and biological evaluation of a series of aromatic bisphosphonates.

Barney RJ, Wasko BM, Dudakovic A, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2010 Oct 15;18(20):7212-20. doi: 10.1016/j.bmc.2010.08.036. Epub 2010 Aug 19.

PMID:
20832326
[PubMed - indexed for MEDLINE]
12.

The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.

Ling Y, Li ZH, Miranda K, Oldfield E, Moreno SN.

J Biol Chem. 2007 Oct 19;282(42):30804-16. Epub 2007 Aug 27.

PMID:
17724033
[PubMed - indexed for MEDLINE]
Free Article
13.

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.

Liu YL, Lindert S, Zhu W, Wang K, McCammon JA, Oldfield E.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2530-9. doi: 10.1073/pnas.1409061111. Epub 2014 Jun 9.

PMID:
24927548
[PubMed - indexed for MEDLINE]
Free Article
14.

Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.

Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC.

J Biol Chem. 2001 Apr 13;276(15):11624-30. Epub 2001 Jan 4.

PMID:
11152452
[PubMed - indexed for MEDLINE]
Free Article
15.

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.

De Schutter JW, Shaw J, Lin YS, Tsantrizos YS.

Bioorg Med Chem. 2012 Sep 15;20(18):5583-91. doi: 10.1016/j.bmc.2012.07.019. Epub 2012 Jul 24.

PMID:
22884353
[PubMed - indexed for MEDLINE]
16.

Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays.

Henriksen ST, Liu J, Estiu G, Oltvai ZN, Wiest O.

Bioorg Med Chem. 2010 Jul 15;18(14):5148-56. doi: 10.1016/j.bmc.2010.05.060. Epub 2010 Jun 1.

PMID:
20573514
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.

Dunford JE.

Curr Pharm Des. 2010;16(27):2961-9. Review.

PMID:
20722615
[PubMed - indexed for MEDLINE]
19.

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I.

J Antimicrob Chemother. 2010 Dec;65(12):2566-73. doi: 10.1093/jac/dkq349. Epub 2010 Sep 22.

PMID:
20861142
[PubMed - indexed for MEDLINE]
Free Article
20.

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.

Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, Guo RT.

J Am Chem Soc. 2014 Feb 19;136(7):2892-6. doi: 10.1021/ja413127v. Epub 2014 Feb 5.

PMID:
24475925
[PubMed - indexed for MEDLINE]

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