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Results: 1 to 20 of 109

1.

MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.

Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T.

Mol Cancer Res. 2011 Aug;9(8):1100-11. doi: 10.1158/1541-7786.MCR-11-0007. Epub 2011 Jun 21.

PMID:
21693595
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity.

Huang JW, Wang Y, Dhillon KK, Calses P, Villegas E, Mitchell PS, Tewari M, Kemp CJ, Taniguchi T.

Mol Cancer Res. 2013 Dec;11(12):1564-73. doi: 10.1158/1541-7786.MCR-13-0292. Epub 2013 Oct 2.

PMID:
24088786
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells.

Huang H, Tian H, Duan Z, Cao Y, Zhang XS, Sun F.

Cell Signal. 2014 May;26(5):903-11. doi: 10.1016/j.cellsig.2014.01.016. Epub 2014 Jan 22.

PMID:
24462707
[PubMed - indexed for MEDLINE]
4.

MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.

Wang Y, Huang JW, Calses P, Kemp CJ, Taniguchi T.

Cancer Res. 2012 Aug 15;72(16):4037-46. doi: 10.1158/0008-5472.CAN-12-0103. Epub 2012 Jul 3.

PMID:
22761336
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.

Ha K, Fiskus W, Rao R, Balusu R, Venkannagari S, Nalabothula NR, Bhalla KN.

Mol Cancer Ther. 2011 Jul;10(7):1194-206. doi: 10.1158/1535-7163.MCT-11-0094. Epub 2011 May 12.

PMID:
21566061
[PubMed - indexed for MEDLINE]
Free Article
6.

miR-181a and miR-630 regulate cisplatin-induced cancer cell death.

Galluzzi L, Morselli E, Vitale I, Kepp O, Senovilla L, Criollo A, Servant N, Paccard C, Hupé P, Robert T, Ripoche H, Lazar V, Harel-Bellan A, Dessen P, Barillot E, Kroemer G.

Cancer Res. 2010 Mar 1;70(5):1793-803. doi: 10.1158/0008-5472.CAN-09-3112. Epub 2010 Feb 9.

PMID:
20145152
[PubMed - indexed for MEDLINE]
Free Article
7.

ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response.

Martin NT, Nakamura K, Davies R, Nahas SA, Brown C, Tunuguntla R, Gatti RA, Hu H.

PLoS Genet. 2013 May;9(5):e1003505. doi: 10.1371/journal.pgen.1003505. Epub 2013 May 16.

PMID:
23696749
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.

Halicka HD, Huang X, Traganos F, King MA, Dai W, Darzynkiewicz Z.

Cell Cycle. 2005 Feb;4(2):339-45. Epub 2005 Feb 21.

PMID:
15655354
[PubMed - indexed for MEDLINE]
Free Article
9.

miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down-regulating TWIST.

Zhou Y, Huang Z, Wu S, Zang X, Liu M, Shi J.

J Exp Clin Cancer Res. 2014 Jan 27;33:12. doi: 10.1186/1756-9966-33-12.

PMID:
24468065
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.

J Biol Chem. 2003 May 30;278(22):20303-12. Epub 2003 Mar 25.

PMID:
12660252
[PubMed - indexed for MEDLINE]
Free Article
11.

The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.

Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K.

J Biol Chem. 2013 May 10;288(19):13269-77. doi: 10.1074/jbc.M112.402560. Epub 2013 Mar 27.

PMID:
23536184
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention.

Srivastava N, Manvati S, Srivastava A, Pal R, Kalaiarasan P, Chattopadhyay S, Gochhait S, Dua R, Bamezai RN.

Breast Cancer Res. 2011 Apr 4;13(2):R39. doi: 10.1186/bcr2861.

PMID:
21463514
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability.

Yu T, MacPhail SH, Banáth JP, Klokov D, Olive PL.

DNA Repair (Amst). 2006 Aug 13;5(8):935-46. Epub 2006 Jun 30.

PMID:
16814620
[PubMed - indexed for MEDLINE]
14.

MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.

PMID:
12607005
[PubMed - indexed for MEDLINE]
15.

Proteasome function is required for DNA damage response and fanconi anemia pathway activation.

Jacquemont C, Taniguchi T.

Cancer Res. 2007 Aug 1;67(15):7395-405.

PMID:
17671210
[PubMed - indexed for MEDLINE]
Free Article
16.

Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity.

Munshi A, Kurland JF, Nishikawa T, Tanaka T, Hobbs ML, Tucker SL, Ismail S, Stevens C, Meyn RE.

Clin Cancer Res. 2005 Jul 1;11(13):4912-22.

PMID:
16000590
[PubMed - indexed for MEDLINE]
Free Article
17.

MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells.

Park JM, Huang S, Tougeron D, Sinicrope FA.

PLoS One. 2013 May 28;8(5):e65369. doi: 10.1371/journal.pone.0065369. Print 2013.

PMID:
23724141
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.

Gasparini P, Lovat F, Fassan M, Casadei L, Cascione L, Jacob NK, Carasi S, Palmieri D, Costinean S, Shapiro CL, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4536-41. doi: 10.1073/pnas.1402604111. Epub 2014 Mar 10.

PMID:
24616504
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

BCLAF1 is a radiation-induced H2AX-interacting partner involved in γH2AX-mediated regulation of apoptosis and DNA repair.

Lee YY, Yu YB, Gunawardena HP, Xie L, Chen X.

Cell Death Dis. 2012 Jul 26;3:e359. doi: 10.1038/cddis.2012.76.

PMID:
22833098
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult.

Bosco EE, Mayhew CN, Hennigan RF, Sage J, Jacks T, Knudsen ES.

Nucleic Acids Res. 2004 Jan 2;32(1):25-34. Print 2004.

PMID:
14704340
[PubMed - indexed for MEDLINE]
Free PMC Article
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