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Results: 1 to 20 of 93

1.

Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.

Park HW, Kim JY, Choi SK, Lee YH, Zeng W, Kim KH, Muallem S, Lee MG.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10750-5. doi: 10.1073/pnas.1104271108. Epub 2011 Jun 13.

PMID:
21670282
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.

Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP.

Nat Genet. 2003 Dec;35(4):372-6. Epub 2003 Nov 9.

PMID:
14608358
[PubMed - indexed for MEDLINE]
3.

Transient receptor potential canonical type 3 channels and blood pressure in humans.

Thilo F, Baumunk D, Krause H, Schrader M, Miller K, Loddenkemper C, Zakrzewicz A, Krueger K, Zidek W, Tepel M.

J Hypertens. 2009 Jun;27(6):1217-23. doi: 10.1097/HJH.0b013e32832a5a9f.

PMID:
19417689
[PubMed - indexed for MEDLINE]
4.

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.

Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):680-4. Epub 2003 Jan 6.

PMID:
12515852
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4020-4. Epub 2007 Feb 26.

PMID:
17360470
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

WNK kinases influence TRPV4 channel function and localization.

Fu Y, Subramanya A, Rozansky D, Cohen DM.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1305-14. Epub 2006 Jan 10.

PMID:
16403833
[PubMed - indexed for MEDLINE]
Free Article
7.

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.

Bergaya S, Faure S, Baudrie V, Rio M, Escoubet B, Bonnin P, Henrion D, Loirand G, Achard JM, Jeunemaitre X, Hadchouel J.

Hypertension. 2011 Sep;58(3):439-45. doi: 10.1161/HYPERTENSIONAHA.111.172429. Epub 2011 Jul 18.

PMID:
21768522
[PubMed - indexed for MEDLINE]
Free Article
8.

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.

Clin Exp Nephrol. 2012 Aug;16(4):530-8.

PMID:
22294159
[PubMed - indexed for MEDLINE]
9.

Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice.

Yang SS, Hsu YJ, Chiga M, Rai T, Sasaki S, Uchida S, Lin SH.

Endocrinology. 2010 Apr;151(4):1829-36. doi: 10.1210/en.2009-0951. Epub 2010 Feb 24.

PMID:
20181799
[PubMed - indexed for MEDLINE]
10.

Characterization of the kinase activity of a WNK4 protein complex.

Ahlstrom R, Yu AS.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F685-92. doi: 10.1152/ajprenal.00358.2009. Epub 2009 Jul 8.

PMID:
19587141
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.

Na T, Wu G, Peng JB.

Biochem Biophys Res Commun. 2012 Mar 9;419(2):293-8. doi: 10.1016/j.bbrc.2012.02.013. Epub 2012 Feb 11.

PMID:
22342722
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.

Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7838-43. doi: 10.1073/pnas.1304592110. Epub 2013 Apr 1.

PMID:
23576762
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.

Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP.

Nat Genet. 2006 Oct;38(10):1124-32. Epub 2006 Sep 10.

PMID:
16964266
[PubMed - indexed for MEDLINE]
14.

Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.

Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14877-82. Epub 2004 Oct 1.

PMID:
15465913
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.

Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4690-4. Epub 2004 Mar 19.

PMID:
15070779
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S.

Cell Rep. 2013 Mar 28;3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28.

PMID:
23453970
[PubMed - indexed for MEDLINE]
Free Article
17.

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.

Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2064-9. Epub 2004 Feb 9.

PMID:
14769928
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.

Jiang Y, Ferguson WB, Peng JB.

Am J Physiol Renal Physiol. 2007 Feb;292(2):F545-54. Epub 2006 Oct 3.

PMID:
17018846
[PubMed - indexed for MEDLINE]
Free Article
19.

Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.

Shirakawa H, Sakimoto S, Nakao K, Sugishita A, Konno M, Iida S, Kusano A, Hashimoto E, Nakagawa T, Kaneko S.

J Neurosci. 2010 Sep 29;30(39):13116-29. doi: 10.1523/JNEUROSCI.1890-10.2010.

PMID:
20881130
[PubMed - indexed for MEDLINE]
Free Article
20.

A novel protein kinase signaling pathway essential for blood pressure regulation in humans.

Kahle KT, Rinehart J, Giebisch G, Gamba G, Hebert SC, Lifton RP.

Trends Endocrinol Metab. 2008 Apr;19(3):91-5. doi: 10.1016/j.tem.2008.01.001. Epub 2008 Feb 14. Review.

PMID:
18280177
[PubMed - indexed for MEDLINE]

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