Similar articles for PMID: 21655985

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1

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.

Jung WS, Yoo YJ, Park JW, Park SR, Han AR, Ban YH, Kim EJ, Kim E, Yoon YJ. Jung WS, et al. Appl Microbiol Biotechnol. 2011 Sep;91(5):1389-97. doi: 10.1007/s00253-011-3348-6. Epub 2011 Jun 8. Appl Microbiol Biotechnol. 2011. PMID: 21655985

2

Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011.

Mo S, Lee SK, Jin YY, Oh CH, Suh JW. Mo S, et al. Appl Microbiol Biotechnol. 2013 Apr;97(7):3053-62. doi: 10.1007/s00253-012-4413-5. Epub 2012 Oct 2. Appl Microbiol Biotechnol. 2013. PMID: 23053074

3

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor.

Mo S, Ban YH, Park JW, Yoo YJ, Yoon YJ. Mo S, et al. J Ind Microbiol Biotechnol. 2009 Dec;36(12):1473-82. doi: 10.1007/s10295-009-0635-7. Epub 2009 Sep 12. J Ind Microbiol Biotechnol. 2009. PMID: 19756799

4

Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae.

Mutka SC, Bondi SM, Carney JR, Da Silva NA, Kealey JT. Mutka SC, et al. FEMS Yeast Res. 2006 Jan;6(1):40-7. doi: 10.1111/j.1567-1356.2005.00001.x. FEMS Yeast Res. 2006. PMID: 16423069

5

Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus.

Wang J, Wang C, Song K, Wen J. Wang J, et al. Microb Cell Fact. 2017 Oct 3;16(1):169. doi: 10.1186/s12934-017-0787-5. Microb Cell Fact. 2017. PMID: 28974216 Free PMC article.

6

Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization.

Zhu X, Zhang W, Chen X, Wu H, Duan Y, Xu Z. Zhu X, et al. Biotechnol Bioeng. 2010 Oct 15;107(3):506-15. doi: 10.1002/bit.22819. Biotechnol Bioeng. 2010. PMID: 20517869

7

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production.

Murli S, Kennedy J, Dayem LC, Carney JR, Kealey JT. Murli S, et al. J Ind Microbiol Biotechnol. 2003 Aug;30(8):500-9. doi: 10.1007/s10295-003-0073-x. Epub 2003 Jul 26. J Ind Microbiol Biotechnol. 2003. PMID: 12898389

8

Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli.

Zhang H, Boghigian BA, Pfeifer BA. Zhang H, et al. Biotechnol Bioeng. 2010 Feb 15;105(3):567-73. doi: 10.1002/bit.22560. Biotechnol Bioeng. 2010. PMID: 19806677 Free PMC article.

9

AccR, a TetR Family Transcriptional Repressor, Coordinates Short-Chain Acyl Coenzyme A Homeostasis in Streptomyces avermitilis.

Lyu M, Cheng Y, Han X, Wen Y, Song Y, Li J, Chen Z. Lyu M, et al. Appl Environ Microbiol. 2020 Jun 2;86(12):e00508-20. doi: 10.1128/AEM.00508-20. Print 2020 Jun 2. Appl Environ Microbiol. 2020. PMID: 32303550 Free PMC article.

10

Biosynthesis of rapamycin and its regulation: past achievements and recent progress.

Park SR, Yoo YJ, Ban YH, Yoon YJ. Park SR, et al. J Antibiot (Tokyo). 2010 Aug;63(8):434-41. doi: 10.1038/ja.2010.71. Epub 2010 Jun 30. J Antibiot (Tokyo). 2010. PMID: 20588302 Review.

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