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Results: 1 to 20 of 101

1.

Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium.

Terbach N, Shah R, Kelemen R, Klein PS, Gordienko D, Brown NA, Wilkinson CJ, Williams RS.

J Cell Sci. 2011 Jul 1;124(Pt 13):2267-76. doi: 10.1242/jcs.084285. Epub 2011 Jun 7.

PMID:
21652627
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

Elphick LM, Pawolleck N, Guschina IA, Chaieb L, Eikel D, Nau H, Harwood JL, Plant NJ, Williams RS.

Dis Model Mech. 2012 Mar;5(2):231-40. doi: 10.1242/dmm.008391. Epub 2011 Oct 14.

PMID:
22003123
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid.

Xu X, Müller-Taubenberger A, Adley KE, Pawolleck N, Lee VW, Wiedemann C, Sihra TS, Maniak M, Jin T, Williams RS.

Eukaryot Cell. 2007 Jun;6(6):899-906. Epub 2007 Apr 13.

PMID:
17435006
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.

Chang P, Orabi B, Deranieh RM, Dham M, Hoeller O, Shimshoni JA, Yagen B, Bialer M, Greenberg ML, Walker MC, Williams RS.

Dis Model Mech. 2012 Jan;5(1):115-24. doi: 10.1242/dmm.008029. Epub 2011 Aug 29.

PMID:
21876211
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior.

Shimshoni JA, Dalton EC, Jenkins A, Eyal S, Ewan K, Williams RS, Pessah N, Yagen B, Harwood AJ, Bialer M.

Mol Pharmacol. 2007 Mar;71(3):884-92. Epub 2006 Dec 13.

PMID:
17167030
[PubMed - indexed for MEDLINE]
Free Article
6.

The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum.

Boeckeler K, Adley K, Xu X, Jenkins A, Jin T, Williams RS.

Eur J Cell Biol. 2006 Sep;85(9-10):1047-57. Epub 2006 Jun 8.

PMID:
16759735
[PubMed - indexed for MEDLINE]
7.

Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

Gibbs JP, Adeyeye MC, Yang Z, Shen DD.

Epilepsy Res. 2004 Jan;58(1):53-66.

PMID:
15066675
[PubMed - indexed for MEDLINE]
8.

Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure.

Eickholt BJ, Towers GJ, Ryves WJ, Eikel D, Adley K, Ylinen LM, Chadborn NH, Harwood AJ, Nau H, Williams RS.

Mol Pharmacol. 2005 May;67(5):1426-33. Epub 2005 Feb 1.

PMID:
15687223
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mechanism of valproic acid uptake by isolated rat brain microvessels.

Naora K, Shen DD.

Epilepsy Res. 1995 Oct;22(2):97-106.

PMID:
8777904
[PubMed - indexed for MEDLINE]
10.

Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.

Baltes S, Fedrowitz M, Tortós CL, Potschka H, Löscher W.

J Pharmacol Exp Ther. 2007 Jan;320(1):331-43. Epub 2006 Oct 16.

PMID:
17043155
[PubMed - indexed for MEDLINE]
Free Article
11.

Saturable transport of valproic acid in rat choroid plexus in vitro.

Naora K, Ichikawa N, Nishimura N, Hirano H, Shen DD, Iwamoto K.

J Pharm Sci. 1996 Apr;85(4):423-6.

PMID:
8901082
[PubMed - indexed for MEDLINE]
12.

Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo.

Gurvich N, Berman MG, Wittner BS, Gentleman RC, Klein PS, Green JB.

FASEB J. 2005 Jul;19(9):1166-8. Epub 2005 May 18.

PMID:
15901671
[PubMed - indexed for MEDLINE]
Free Article
13.

Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter.

Adkison KD, Shen DD.

J Pharmacol Exp Ther. 1996 Mar;276(3):1189-200.

PMID:
8786552
[PubMed - indexed for MEDLINE]
14.

Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).

Ushigome F, Takanaga H, Matsuo H, Tsukimori K, Nakano H, Ohtani H, Sawada Y.

Eur J Pharmacol. 2001 Apr 13;417(3):169-76.

PMID:
11334847
[PubMed - indexed for MEDLINE]
15.
16.

Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes--a preliminary study.

Wang CC, Chen PS, Hsu CW, Wu SJ, Lin CT, Gean PW.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Apr 27;37(1):111-20. doi: 10.1016/j.pnpbp.2012.01.017. Epub 2012 Feb 7.

PMID:
22343008
[PubMed - indexed for MEDLINE]
17.

Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.

Papakrivos J, Sá JM, Wellems TE.

PLoS One. 2012;7(6):e39569. doi: 10.1371/journal.pone.0039569. Epub 2012 Jun 19.

PMID:
22724026
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis.

Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA.

J Exp Biol. 1997 Jan;200(Pt 2):269-86. Review.

PMID:
9050235
[PubMed - indexed for MEDLINE]
Free Article
19.

Structure-function studies for the panacea, valproic acid.

Terbach N, Williams RS.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1126-32. doi: 10.1042/BST0371126. Review.

PMID:
19754465
[PubMed - indexed for MEDLINE]
20.

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.

Fraser CM, Sills GJ, Butler E, Thompson GG, Lindsay K, Duncan R, Howatson A, Brodie MJ.

Epileptic Disord. 1999 Sep;1(3):153-7.

PMID:
10937147
[PubMed - indexed for MEDLINE]

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