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Results: 1 to 20 of 129

1.

Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns.

Supek F, Ramljak TŠ, Marjanović M, Buljubašić M, Kragol G, Ilić N, Smuc T, Zahradka D, Mlinarić-Majerski K, Kralj M.

Eur J Med Chem. 2011 Aug;46(8):3444-54. doi: 10.1016/j.ejmech.2011.05.009. Epub 2011 May 13.

PMID:
21628081
[PubMed - indexed for MEDLINE]
2.

Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores.

Marjanović M, Kralj M, Supek F, Frkanec L, Piantanida I, Smuc T, Tusek-Bozić L.

J Med Chem. 2007 Mar 8;50(5):1007-18. Epub 2007 Feb 15.

PMID:
17300184
[PubMed - indexed for MEDLINE]
3.

Computational structure-activity study directs synthesis of novel antitumor enkephalin analogs.

Gredicak M, Supek F, Kralj M, Majer Z, Hollósi M, Smuc T, Mlinarić-Majerski K, Horvat S.

Amino Acids. 2010 Apr;38(4):1185-91. doi: 10.1007/s00726-009-0329-5. Epub 2009 Jul 29.

PMID:
19639251
[PubMed - indexed for MEDLINE]
4.

Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro.

Horvat M, Uzelac L, Marjanović M, Cindro N, Franković O, Mlinarić-Majerski K, Kralj M, Basarić N.

Chem Biol Drug Des. 2012 Apr;79(4):497-506. doi: 10.1111/j.1747-0285.2011.01305.x. Epub 2012 Jan 30.

PMID:
22176512
[PubMed - indexed for MEDLINE]
5.

Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives.

Siwy M, Sek D, Kaczmarczyk B, Jaroszewicz I, Nasulewicz A, Pelczyñska M, Nevozhay D, Opolski A.

J Med Chem. 2006 Jan 26;49(2):806-10.

PMID:
16420065
[PubMed - indexed for MEDLINE]
6.

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents.

Xue N, Yang X, Wu R, Chen J, He Q, Yang B, Lu X, Hu Y.

Bioorg Med Chem. 2008 Mar 1;16(5):2550-7. doi: 10.1016/j.bmc.2007.11.048. Epub 2007 Nov 22.

PMID:
18226907
[PubMed - indexed for MEDLINE]
7.

Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents.

Zhu W, Liu Y, Zhai X, Wang X, Zhu Y, Wu D, Zhou H, Gong P, Zhao Y.

Eur J Med Chem. 2012 Nov;57:162-75. doi: 10.1016/j.ejmech.2012.09.002. Epub 2012 Sep 10.

PMID:
23059545
[PubMed - indexed for MEDLINE]
8.

Synthesis, DNA cleavage, and cytotoxicity of a series of bis(propargylic) sulfone crown ethers.

McPhee MM, Kerwin SM.

Bioorg Med Chem. 2001 Nov;9(11):2809-18.

PMID:
11597461
[PubMed - indexed for MEDLINE]
9.

Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells.

Xia Y, Dong ZW, Zhao BX, Ge X, Meng N, Shin DS, Miao JY.

Bioorg Med Chem. 2007 Nov 15;15(22):6893-9. Epub 2007 Aug 21.

PMID:
17804244
[PubMed - indexed for MEDLINE]
10.

In vitro and in vivo growth inhibition and G1 arrest in human cancer cell lines by diaminophenyladamantane derivatives.

Wang JJ, Chen YC, Chi CW, Huang KT, Chern YT.

Anticancer Drugs. 2004 Aug;15(7):697-705.

PMID:
15269601
[PubMed - indexed for MEDLINE]
11.

Synthesis, cytotoxicity testing, and structure-activity relationships of novel 6-chloro-7-(4-phenylimino-4H-3,1-benzoxazin-2-yl)-3-(substituted)-1,4,2-benzodithiazine 1,1-dioxides.

Pomarnacka E, Kornicka A, Kuchnio A, Heinrichs M, Grünert R, Gdaniec M, Bednarski PJ.

Arch Pharm (Weinheim). 2011 Jul;344(7):431-41. doi: 10.1002/ardp.201000183. Epub 2011 May 25.

PMID:
21618270
[PubMed - indexed for MEDLINE]
12.

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.

Shanab K, Schirmer E, Knafl H, Wulz E, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3950-2. doi: 10.1016/j.bmcl.2010.05.003. Epub 2010 May 7.

PMID:
20537894
[PubMed - indexed for MEDLINE]
13.

Synthesis and structure-activity relationship studies of cytotoxic ester and ether anhydrovinblastine derivatives.

Zhang HK, Shao Y, Ding H, Hu LH.

J Nat Prod. 2008 Oct;71(10):1669-76. doi: 10.1021/np800284h. Epub 2008 Sep 4.

PMID:
18771244
[PubMed - indexed for MEDLINE]
14.

Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs.

Al-Obaid AM, Abdel-Hamide SG, El-Kashef HA, Abdel-Aziz AA, El-Azab AS, Al-Khamees HA, El-Subbagh HI.

Eur J Med Chem. 2009 Jun;44(6):2379-91. doi: 10.1016/j.ejmech.2008.09.015. Epub 2008 Sep 23.

PMID:
18950904
[PubMed - indexed for MEDLINE]
15.

Structure-activity relationships of antineoplastic ring-substituted ether phospholipid derivatives.

Papazafiri P, Avlonitis N, Angelou P, Calogeropoulou T, Koufaki M, Scoulica E, Fragiadaki I.

Cancer Chemother Pharmacol. 2005 Sep;56(3):261-70. Epub 2005 Apr 26.

PMID:
15856232
[PubMed - indexed for MEDLINE]
16.

Synthesis, antitumor evaluation, molecular modeling and quantitative structure-activity relationship (QSAR) of some novel arylazopyrazolodiazine and triazine analogs.

El-Shafei A, Fadda AA, Khalil AM, Ameen TA, Badria FA.

Bioorg Med Chem. 2009 Jul 15;17(14):5096-105. doi: 10.1016/j.bmc.2009.05.053. Epub 2009 May 29.

PMID:
19527933
[PubMed - indexed for MEDLINE]
17.

Crown ether-peptide construct selectively kills cancer cells.

Rotello VM.

Chem Biol Drug Des. 2008 Jul;72(1):1-2. doi: 10.1111/j.1747-0285.2008.00674.x. Epub 2008 Jun 12. No abstract available.

PMID:
18554255
[PubMed - indexed for MEDLINE]
18.

Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives.

Kolokythas G, Pouli N, Marakos P, Pratsinis H, Kletsas D.

Eur J Med Chem. 2006 Jan;41(1):71-9. Epub 2005 Nov 21.

PMID:
16300857
[PubMed - indexed for MEDLINE]
19.

Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.

Bolognese A, Correale G, Manfra M, Lavecchia A, Mazzoni O, Novellino E, La Colla P, Sanna G, Loddo R.

J Med Chem. 2004 Feb 12;47(4):849-58.

PMID:
14761187
[PubMed - indexed for MEDLINE]
20.

Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells.

Xia Y, Fan CD, Zhao BX, Zhao J, Shin DS, Miao JY.

Eur J Med Chem. 2008 Nov;43(11):2347-53. doi: 10.1016/j.ejmech.2008.01.021. Epub 2008 Jan 31.

PMID:
18313806
[PubMed - indexed for MEDLINE]

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