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SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.

Zhang F, Landford WN, Ng M, McNatt MW, Bieniasz PD, Hatziioannou T.

PLoS Pathog. 2011 May;7(5):e1002039. doi: 10.1371/journal.ppat.1002039. Epub 2011 May 19.


Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.

Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT.

PLoS Pathog. 2013;9(7):e1003487. doi: 10.1371/journal.ppat.1003487. Epub 2013 Jul 11.


Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses.

Lim ES, Malik HS, Emerman M.

J Virol. 2010 Jul;84(14):7124-34. doi: 10.1128/JVI.00468-10. Epub 2010 May 5.


Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.

Jia B, Serra-Moreno R, Neidermyer W, Rahmberg A, Mackey J, Fofana IB, Johnson WE, Westmoreland S, Evans DT.

PLoS Pathog. 2009 May;5(5):e1000429. doi: 10.1371/journal.ppat.1000429. Epub 2009 May 15.


Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene.

Nikovics K, Dazza MC, Ekwalanga M, Mammano F, Clavel F, Saragosti S.

PLoS One. 2012;7(4):e35411. doi: 10.1371/journal.pone.0035411. Epub 2012 Apr 17.


Nef proteins from simian immunodeficiency viruses are tetherin antagonists.

Zhang F, Wilson SJ, Landford WC, Virgen B, Gregory D, Johnson MC, Munch J, Kirchhoff F, Bieniasz PD, Hatziioannou T.

Cell Host Microbe. 2009 Jul 23;6(1):54-67. doi: 10.1016/j.chom.2009.05.008. Epub 2009 Jun 4.


HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef.

Sauter D, Hué S, Petit SJ, Plantier JC, Towers GJ, Kirchhoff F, Gupta RK.

Retrovirology. 2011 Dec 15;8:103. doi: 10.1186/1742-4690-8-103.


Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin.

Kluge SF, Mack K, Iyer SS, Pujol FM, Heigele A, Learn GH, Usmani SM, Sauter D, Joas S, Hotter D, Bibollet-Ruche F, Plenderleith LJ, Peeters M, Geyer M, Sharp PM, Fackler OT, Hahn BH, Kirchhoff F.

Cell Host Microbe. 2014 Nov 12;16(5):639-50. doi: 10.1016/j.chom.2014.10.002. Epub 2014 Nov 12.


Tetherin antagonism by primate lentiviral nef proteins.

Sauter D, Kirchhoff F.

Curr HIV Res. 2011 Oct;9(7):514-23.


Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.

Lock M, Greenberg ME, Iafrate AJ, Swigut T, Muench J, Kirchhoff F, Shohdy N, Skowronski J.

EMBO J. 1999 May 17;18(10):2722-33.


Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.

Brenner M, Münch J, Schindler M, Wildum S, Stolte N, Stahl-Hennig C, Fuchs D, Mätz-Rensing K, Franz M, Heeney J, Ten Haaft P, Swigut T, Hrecka K, Skowronski J, Kirchhoff F.

J Virol. 2006 May;80(9):4469-81.


Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.

Le Tortorec A, Willey S, Neil SJ.

Viruses. 2011 May;3(5):520-40. doi: 10.3390/v3050520. Epub 2011 May 6. Review.


Adaptation of human and simian immunodeficiency viruses for resistance to tetherin/BST-2.

Serra-Moreno R, Evans DT.

Curr HIV Res. 2012 Jun;10(4):277-82.


Two amino acid substitutions in the SIV Nef protein mediate associations with distinct cellular kinases.

Barber SA, Maughan MF, Roos JW, Clements JE.

Virology. 2000 Oct 25;276(2):329-38.


Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.

Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J, Xiong Y.

Elife. 2014 Apr 29;3:e02362. doi: 10.7554/eLife.02362.


Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo.

Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F.

J Virol. 2000 Nov;74(21):9836-44. Erratum in: J Virol 2000 Dec;74(24):12002.


Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.

Lv M, Wang J, Wang X, Zuo T, Zhu Y, Kong W, Yu X.

PLoS One. 2011;6(6):e20890. doi: 10.1371/journal.pone.0020890. Epub 2011 Jun 2.

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