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Results: 1 to 20 of 176

1.

Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.

Zhu CZ, Chin CL, Rustay NR, Zhong C, Mikusa J, Chandran P, Salyers A, Gomez E, Simler G, Lewis LG, Gauvin D, Baker S, Pai M, Tovcimak A, Brown J, Komater V, Fox GB, Decker MW, Jacobson PB, Gopalakrishnan M, Lee CH, Honore P.

Biochem Pharmacol. 2011 Oct 15;82(8):967-76. doi: 10.1016/j.bcp.2011.05.007. Epub 2011 May 17.

PMID:
21620806
[PubMed - indexed for MEDLINE]
2.

α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain.

Lee CH, Zhu C, Malysz J, Campbell T, Shaughnessy T, Honore P, Polakowski J, Gopalakrishnan M.

Biochem Pharmacol. 2011 Oct 15;82(8):959-66. doi: 10.1016/j.bcp.2011.06.044. Epub 2011 Jul 7.

PMID:
21763685
[PubMed - indexed for MEDLINE]
3.

Antinociceptive activity of α4β2* neuronal nicotinic receptor agonist A-366833 in experimental models of neuropathic and inflammatory pain.

Nirogi R, Jabaris SL, Jayarajan P, Abraham R, Shanmuganathan D, Rasheed MA, Royapalley PK, Goura V.

Eur J Pharmacol. 2011 Oct 1;668(1-2):155-62. doi: 10.1016/j.ejphar.2011.06.032. Epub 2011 Jul 3. Erratum in: Eur J Pharmacol. 2011 Dec 30;673(1-3):101. Jabaris, Sugin Lal [added].

PMID:
21756895
[PubMed - indexed for MEDLINE]
4.

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.

Donnelly-Roberts DL, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Anderson DJ, Campbell JE, Piattoni-Kaplan M, McKenna DG, Wasicak JT, Holladay MW, Williams M, Arneric SP.

J Pharmacol Exp Ther. 1998 May;285(2):777-86.

PMID:
9580626
[PubMed - indexed for MEDLINE]
Free Article
5.

Mapping brain activity following administration of a nicotinic acetylcholine receptor agonist, ABT-594, using functional magnetic resonance imaging in awake rats.

Skoubis PD, Hradil V, Chin CL, Luo Y, Fox GB, McGaraughty S.

Neuroscience. 2006;137(2):583-91. Epub 2005 Nov 14.

PMID:
16289887
[PubMed - indexed for MEDLINE]
6.

Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.

Munro G, Dyhr H, Grunnet M.

Neuropharmacology. 2010 Sep;59(3):208-17. doi: 10.1016/j.neuropharm.2010.05.010. Epub 2010 Jun 1.

PMID:
20562022
[PubMed - indexed for MEDLINE]
7.

The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.

Meyer MD, Decker MW, Rueter LE, Anderson DJ, Dart MJ, Kim KH, Sullivan JP, Williams M.

Eur J Pharmacol. 2000 Mar 30;393(1-3):171-7.

PMID:
10771011
[PubMed - indexed for MEDLINE]
8.

Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats.

Mohler EG, Franklin SR, Rueter LE.

Psychopharmacology (Berl). 2014 Jan;231(1):67-74. doi: 10.1007/s00213-013-3207-5. Epub 2013 Aug 8.

PMID:
23925734
[PubMed - indexed for MEDLINE]
9.

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization.

Bannon AW, Decker MW, Curzon P, Buckley MJ, Kim DJ, Radek RJ, Lynch JK, Wasicak JT, Lin NH, Arnold WH, Holladay MW, Williams M, Arneric SP.

J Pharmacol Exp Ther. 1998 May;285(2):787-94.

PMID:
9580627
[PubMed - indexed for MEDLINE]
Free Article
10.

ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model.

Lynch JJ 3rd, Wade CL, Mikusa JP, Decker MW, Honore P.

Eur J Pharmacol. 2005 Feb 10;509(1):43-8.

PMID:
15713428
[PubMed - indexed for MEDLINE]
11.

In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.

Freitas K, Negus SS, Carroll FI, Damaj MI.

Br J Pharmacol. 2013 Jun;169(3):567-79. doi: 10.1111/j.1476-5381.2012.02226.x.

PMID:
23004024
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.

Ji J, Bunnelle WH, Anderson DJ, Faltynek C, Dyhring T, Ahring PK, Rueter LE, Curzon P, Buckley MJ, Marsh KC, Kempf-Grote A, Meyer MD.

Biochem Pharmacol. 2007 Oct 15;74(8):1253-62. Epub 2007 Aug 12.

PMID:
17854775
[PubMed - indexed for MEDLINE]
13.

Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain.

Kesingland AC, Gentry CT, Panesar MS, Bowes MA, Vernier JM, Cube R, Walker K, Urban L.

Pain. 2000 May;86(1-2):113-8.

PMID:
10779668
[PubMed - indexed for MEDLINE]
14.

Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.

Boyce S, Webb JK, Shepheard SL, Russell MG, Hill RG, Rupniak NM.

Pain. 2000 Apr;85(3):443-50.

PMID:
10781917
[PubMed - indexed for MEDLINE]
15.

Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.

Decker MW, Bannon AW, Buckley MJ, Kim DJ, Holladay MW, Ryther KB, Lin NH, Wasicak JT, Williams M, Arneric SP.

Eur J Pharmacol. 1998 Apr 3;346(1):23-33.

PMID:
9617748
[PubMed - indexed for MEDLINE]
16.

Modulators of nicotinic acetylcholine receptors as analgesics.

Jain KK.

Curr Opin Investig Drugs. 2004 Jan;5(1):76-81. Review.

PMID:
14983978
[PubMed - indexed for MEDLINE]
17.

Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics.

Decker MW, Meyer MD.

Biochem Pharmacol. 1999 Sep 15;58(6):917-23. Review.

PMID:
10509744
[PubMed - indexed for MEDLINE]
18.

Positive allosteric modulation of α4β2 nAChR agonist induced behaviour.

Rode F, Munro G, Holst D, Nielsen EØ, Troelsen KB, Timmermann DB, Rønn LC, Grunnet M.

Brain Res. 2012 Jun 6;1458:67-75. doi: 10.1016/j.brainres.2012.03.064. Epub 2012 Apr 4.

PMID:
22552114
[PubMed - indexed for MEDLINE]
19.

A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain.

Rowbotham MC, Duan WR, Thomas J, Nothaft W, Backonja MM.

Pain. 2009 Dec;146(3):245-52. doi: 10.1016/j.pain.2009.06.013. Epub 2009 Jul 24.

PMID:
19632048
[PubMed - indexed for MEDLINE]
20.

Spinal mechanisms underlying A-85380-induced effects on acute thermal pain.

Rueter LE, Meyer MD, Decker MW.

Brain Res. 2000 Jul 28;872(1-2):93-101.

PMID:
10924680
[PubMed - indexed for MEDLINE]

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