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Items: 1 to 20 of 75

1.

The use of site-directed mutagenesis to study GPCRs.

Conner AC, Barwell J, Poyner DR, Wheatley M.

Methods Mol Biol. 2011;746:85-98. doi: 10.1007/978-1-61779-126-0_5.

PMID:
21607853
3.

Techniques: how to boost GPCR mutagenesis studies using yeast.

Beukers MW, Ijzerman AP.

Trends Pharmacol Sci. 2005 Oct;26(10):533-9. Review.

PMID:
16126284
4.
5.

Modeling small molecule-compound binding to G-protein-coupled receptors.

Vaidehi N, Pease JE, Horuk R.

Methods Enzymol. 2009;460:263-88. doi: 10.1016/S0076-6879(09)05213-6.

PMID:
19446730
6.

A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation.

Sansuk K, Deupi X, Torrecillas IR, Jongejan A, Nijmeijer S, Bakker RA, Pardo L, Leurs R.

Mol Pharmacol. 2011 Feb;79(2):262-9. doi: 10.1124/mol.110.066068. Epub 2010 Nov 16.

7.

Receptor mutagenesis strategies for examination of structure-function relationships.

Blomenröhr M, Vischer HF, Bogerd J.

Methods Mol Biol. 2004;259:307-22.

PMID:
15250501
8.

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies.

Vohra S, Taddese B, Conner AC, Poyner DR, Hay DL, Barwell J, Reeves PJ, Upton GJ, Reynolds CA.

J R Soc Interface. 2012 Dec 12;10(79):20120846. doi: 10.1098/rsif.2012.0846. Print 2013 Feb.

9.

Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form.

Tubio MR, Fernandez N, Fitzsimons CP, Copsel S, Santiago S, Shayo C, Davio C, Monczor F.

J Biol Chem. 2010 May 14;285(20):14990-8. doi: 10.1074/jbc.M109.099689. Epub 2010 Mar 18.

10.

Ligand screening system using fusion proteins of G protein-coupled receptors with G protein alpha subunits.

Suga H, Haga T.

Neurochem Int. 2007 Jul-Sep;51(2-4):140-64. Epub 2007 Jun 19. Review.

PMID:
17659814
11.

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

Ye S, Köhrer C, Huber T, Kazmi M, Sachdev P, Yan EC, Bhagat A, RajBhandary UL, Sakmar TP.

J Biol Chem. 2008 Jan 18;283(3):1525-33. Epub 2007 Nov 8.

12.

Site-specific in vitro and in vivo incorporation of molecular probes to study G-protein-coupled receptors.

Daggett KA, Sakmar TP.

Curr Opin Chem Biol. 2011 Jun;15(3):392-8. doi: 10.1016/j.cbpa.2011.03.010. Epub 2011 May 14. Review.

PMID:
21571577
13.

Semliki Forest virus vectors for overexpression of 101 G protein-coupled receptors in mammalian host cells.

Hassaine G, Wagner R, Kempf J, Cherouati N, Hassaine N, Prual C, André N, Reinhart C, Pattus F, Lundstrom K.

Protein Expr Purif. 2006 Feb;45(2):343-51. Epub 2005 Jul 11.

PMID:
16055346
14.

Heterologous expression of GPCRs in fission yeast.

Davey J, Ladds G.

Methods Mol Biol. 2011;746:113-31. doi: 10.1007/978-1-61779-126-0_7.

PMID:
21607855
15.

Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression.

Hawtin SR, Simms J, Conner M, Lawson Z, Parslow RA, Trim J, Sheppard A, Wheatley M.

J Biol Chem. 2006 Dec 15;281(50):38478-88. Epub 2006 Sep 21.

16.

Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.

Capra V, Veltri A, Foglia C, Crimaldi L, Habib A, Parenti M, Rovati GE.

Mol Pharmacol. 2004 Oct;66(4):880-9. Epub 2004 Jun 30.

17.

Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors.

Bhattacharya S, Hall SE, Vaidehi N.

J Mol Biol. 2008 Oct 3;382(2):539-55. doi: 10.1016/j.jmb.2008.06.084. Epub 2008 Jul 7.

PMID:
18638482
18.

A pivot between helices V and VI near the retinal-binding site is necessary for activation in rhodopsins.

Tsukamoto H, Terakita A, Shichida Y.

J Biol Chem. 2010 Mar 5;285(10):7351-7. doi: 10.1074/jbc.M109.078709. Epub 2010 Jan 6.

19.

Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins.

Sterne-Marr R, Dhami GK, Tesmer JJ, Ferguson SS.

Methods Enzymol. 2004;390:310-36.

PMID:
15488186
20.

The regulatory mechanisms of export trafficking of G protein-coupled receptors.

Duvernay MT, Filipeanu CM, Wu G.

Cell Signal. 2005 Dec;17(12):1457-65. Review.

PMID:
16014327
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