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Results: 1 to 20 of 119

1.

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE.

Pharmacogenet Genomics. 2011 Jul;21(7):403-16. doi: 10.1097/FPC.0b013e328346e8c0.

PMID:
21597399
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.

Bloom AJ, von Weymarn LB, Martinez M, Bierut LJ, Goate A, Murphy SE.

Pharmacogenet Genomics. 2013 Dec;23(12):706-16. doi: 10.1097/FPC.0000000000000011.

PMID:
24192532
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.

Bloom AJ, Harari O, Martinez M, Madden PA, Martin NG, Montgomery GW, Rice JP, Murphy SE, Bierut LJ, Goate A.

Hum Mol Genet. 2012 Jul 1;21(13):3050-62. doi: 10.1093/hmg/dds114. Epub 2012 Mar 26.

PMID:
22451501
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.

Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF.

Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1812-9.

PMID:
17035386
[PubMed - indexed for MEDLINE]
Free Article
5.

Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

Nakajima M, Fukami T, Yamanaka H, Higashi E, Sakai H, Yoshida R, Kwon JT, McLeod HL, Yokoi T.

Clin Pharmacol Ther. 2006 Sep;80(3):282-97.

PMID:
16952495
[PubMed - indexed for MEDLINE]
6.

Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.

Nakajima M, Kwon JT, Tanaka N, Zenta T, Yamamoto Y, Yamamoto H, Yamazaki H, Yamamoto T, Kuroiwa Y, Yokoi T.

Clin Pharmacol Ther. 2001 Jan;69(1):72-8.

PMID:
11180041
[PubMed - indexed for MEDLINE]
7.

Characterization of novel CYP2A6 polymorphic alleles (CYP2A6*18 and CYP2A6*19) that affect enzymatic activity.

Fukami T, Nakajima M, Higashi E, Yamanaka H, Sakai H, McLeod HL, Yokoi T.

Drug Metab Dispos. 2005 Aug;33(8):1202-10. Epub 2005 May 17.

PMID:
15900015
[PubMed - indexed for MEDLINE]
Free Article
8.

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF.

Pharmacogenetics. 2004 Sep;14(9):615-26.

PMID:
15475735
[PubMed - indexed for MEDLINE]
9.

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

Fukami T, Nakajima M, Sakai H, McLeod HL, Yokoi T.

Pharmacogenomics J. 2006 Nov-Dec;6(6):401-12. Epub 2006 Apr 25.

PMID:
16636685
[PubMed - indexed for MEDLINE]
10.

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

Bloom AJ, Murphy SE, Martinez M, von Weymarn LB, Bierut LJ, Goate A.

Pharmacogenet Genomics. 2013 Feb;23(2):62-8. doi: 10.1097/FPC.0b013e32835c3b48.

PMID:
23211429
[PubMed - indexed for MEDLINE]
11.

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

Benowitz NL, Swan GE, Jacob P 3rd, Lessov-Schlaggar CN, Tyndale RF.

Clin Pharmacol Ther. 2006 Nov;80(5):457-67.

PMID:
17112802
[PubMed - indexed for MEDLINE]
12.

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, Tyndale RF.

Hum Mutat. 2008 May;29(5):679-88. doi: 10.1002/humu.20698.

PMID:
18360915
[PubMed - indexed for MEDLINE]
13.

The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex.

Zhu AZ, Renner CC, Hatsukami DK, Swan GE, Lerman C, Benowitz NL, Tyndale RF.

Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):708-18. doi: 10.1158/1055-9965.EPI-12-1234-T. Epub 2013 Jan 31.

PMID:
23371292
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.

Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers EM, Tyndale RF.

Mol Pharmacol. 2000 Oct;58(4):747-55.

PMID:
10999944
[PubMed - indexed for MEDLINE]
Free Article
15.

Nicotine metabolism and CYP2A6 allele frequencies in Koreans.

Kwon JT, Nakajima M, Chai S, Yom YK, Kim HK, Yamazaki H, Sohn DR, Yamamoto T, Kuroiwa Y, Yokoi T.

Pharmacogenetics. 2001 Jun;11(4):317-23.

PMID:
11434509
[PubMed - indexed for MEDLINE]
16.

Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.

Piliguian M, Zhu AZ, Zhou Q, Benowitz NL, Ahluwalia JS, Sanderson Cox L, Tyndale RF.

Pharmacogenet Genomics. 2014 Feb;24(2):118-28. doi: 10.1097/FPC.0000000000000026.

PMID:
24305170
[PubMed - indexed for MEDLINE]
17.

Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation.

Nakajima M, Yokoi T.

Drug Metab Pharmacokinet. 2005 Aug;20(4):227-35. Review.

PMID:
16141602
[PubMed - indexed for MEDLINE]
Free Article
18.

Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.

Ring HZ, Valdes AM, Nishita DM, Prasad S, Jacob P 3rd, Tyndale RF, Swan GE, Benowitz NL.

Pharmacogenet Genomics. 2007 Dec;17(12):1007-15.

PMID:
18004205
[PubMed - indexed for MEDLINE]
19.

In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.

Peamkrasatam S, Sriwatanakul K, Kiyotani K, Fujieda M, Yamazaki H, Kamataki T, Yoovathaworn K.

Drug Metab Pharmacokinet. 2006 Dec;21(6):475-84.

PMID:
17220563
[PubMed - indexed for MEDLINE]
Free Article
20.

Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence.

Swan GE, Benowitz NL, Lessov CN, Jacob P 3rd, Tyndale RF, Wilhelmsen K.

Pharmacogenet Genomics. 2005 Feb;15(2):115-25.

PMID:
15861035
[PubMed - indexed for MEDLINE]
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