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Results: 1 to 20 of 106

1.

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.

Ahmed A, Yang J, Maya-Mendoza A, Jackson DA, Ashcroft M.

Cell Death Dis. 2011 May 19;2:e160. doi: 10.1038/cddis.2011.42.

PMID:
21593792
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia.

Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G, Valenti M, Eccles S, Rouschop K, Wouters B, Ashcroft M.

Mol Cell Biol. 2009 Apr;29(8):2243-53. doi: 10.1128/MCB.00959-08. Epub 2009 Feb 17.

PMID:
19223463
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.

Lo PK, Lee JS, Sukumar S.

Cell Signal. 2012 Jan;24(1):316-24. doi: 10.1016/j.cellsig.2011.09.017. Epub 2011 Sep 22.

PMID:
21964066
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Chk2 mediates RITA-induced apoptosis.

de Lange J, Verlaan-de Vries M, Teunisse AF, Jochemsen AG.

Cell Death Differ. 2012 Jun;19(6):980-9. doi: 10.1038/cdd.2011.182. Epub 2011 Dec 9.

PMID:
22158418
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons.

Ye W, Blain SW.

Brain. 2010 Aug;133(Pt 8):2295-312. doi: 10.1093/brain/awq139. Epub 2010 Jul 17.

PMID:
20639548
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.

PMID:
19060337
[PubMed - indexed for MEDLINE]
Free Article
7.

Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways.

Shyur LF, Lee SH, Chang ST, Lo CP, Kuo YH, Wang SY.

Phytomedicine. 2010 Dec 15;18(1):16-24. doi: 10.1016/j.phymed.2010.06.005. Epub 2010 Jul 16.

PMID:
20637573
[PubMed - indexed for MEDLINE]
8.

5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint.

Luciani MG, Campregher C, Fortune JM, Kunkel TA, Gasche C.

Gastroenterology. 2007 Jan;132(1):221-35. Epub 2006 Oct 12.

PMID:
17241873
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation.

Ewald B, Sampath D, Plunkett W.

Mol Cancer Ther. 2007 Apr;6(4):1239-48. Epub 2007 Apr 3.

PMID:
17406032
[PubMed - indexed for MEDLINE]
Free Article
10.

p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest.

Chae HD, Kim SY, Park SE, Kim J, Shin DY.

Exp Mol Med. 2012 Mar 31;44(3):236-40. doi: 10.3858/emm.2012.44.3.018.

PMID:
22198295
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest.

Hammond EM, Green SL, Giaccia AJ.

Mutat Res. 2003 Nov 27;532(1-2):205-13.

PMID:
14643437
[PubMed - indexed for MEDLINE]
12.

Activation of the S phase DNA damage checkpoint by mitomycin C.

Mladenov E, Tsaneva I, Anachkova B.

J Cell Physiol. 2007 May;211(2):468-76.

PMID:
17167777
[PubMed - indexed for MEDLINE]
13.

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.

Spinnler C, Hedström E, Li H, de Lange J, Nikulenkov F, Teunisse AF, Verlaan-de Vries M, Grinkevich V, Jochemsen AG, Selivanova G.

Cell Death Differ. 2011 Nov;18(11):1736-45. doi: 10.1038/cdd.2011.45. Epub 2011 May 6.

PMID:
21546907
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.

J Biol Chem. 2005 Jan 14;280(2):1186-92. Epub 2004 Nov 8.

PMID:
15533933
[PubMed - indexed for MEDLINE]
Free Article
15.

Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer.

Chen L, Fu L, Kong X, Xu J, Wang Z, Ma X, Akiyama Y, Chen Y, Fang J.

Br J Cancer. 2014 Feb 18;110(4):1014-26. doi: 10.1038/bjc.2013.808. Epub 2014 Jan 28.

PMID:
24473398
[PubMed - indexed for MEDLINE]
16.

Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma.

de Lange J, Ly LV, Lodder K, Verlaan-de Vries M, Teunisse AF, Jager MJ, Jochemsen AG.

Oncogene. 2012 Mar 1;31(9):1105-16. doi: 10.1038/onc.2011.309. Epub 2011 Jul 18.

PMID:
21765463
[PubMed - indexed for MEDLINE]
17.

DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis.

Oya E, Ovrevik J, Arlt VM, Nagy E, Phillips DH, Holme JA.

Mutagenesis. 2011 Nov;26(6):697-708. doi: 10.1093/mutage/ger035. Epub 2011 Jun 29.

PMID:
21715570
[PubMed - indexed for MEDLINE]
Free Article
18.

E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG.

Mol Cancer Res. 2004 Apr;2(4):203-14.

PMID:
15140942
[PubMed - indexed for MEDLINE]
Free Article
19.

Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis.

Imreh G, Norberg HV, Imreh S, Zhivotovsky B.

J Cell Sci. 2011 Sep 1;124(Pt 17):2951-63. doi: 10.1242/jcs.081612.

PMID:
21878502
[PubMed - indexed for MEDLINE]
Free Article
20.

Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.

Yun HJ, Hyun SK, Park JH, Kim BW, Kwon HJ.

Mol Cell Biochem. 2012 Apr;363(1-2):281-9. doi: 10.1007/s11010-011-1180-z. Epub 2011 Dec 11.

PMID:
22160829
[PubMed - indexed for MEDLINE]

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