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1.

The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.

Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2011 Aug;338(2):492-502. doi: 10.1124/jpet.111.180521. Epub 2011 May 16.

2.

Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.

Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP.

Toxicol Appl Pharmacol. 2011 May 1;252(3):211-20. doi: 10.1016/j.taap.2011.02.005. Epub 2011 Feb 24.

3.

Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice.

Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li SH, Simpson PM, Hinson JA, James LP.

Toxicol Appl Pharmacol. 2012 Oct 15;264(2):192-201. doi: 10.1016/j.taap.2012.08.001. Epub 2012 Aug 10.

4.

Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1alpha expression.

Salhanick SD, Belikoff B, Orlow D, Holt D, Reenstra W, Buras JA.

Acad Emerg Med. 2006 Jul;13(7):707-14. Epub 2006 Apr 24.

PMID:
16636360
5.

Protective effects of salidroside against acetaminophen-induced toxicity in mice.

Wu YL, Piao DM, Han XH, Nan JX.

Biol Pharm Bull. 2008 Aug;31(8):1523-9.

6.

Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress.

James LP, Donahower B, Burke AS, McCullough S, Hinson JA.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):171-6. Epub 2006 Mar 3.

PMID:
16530163
7.

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O.

J Hepatol. 2013 Sep;59(3):495-503. doi: 10.1016/j.jhep.2013.04.024. Epub 2013 May 9.

PMID:
23665281
8.

Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.

Dambach DM, Durham SK, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65. Epub 2005 Aug 2.

PMID:
16081117
9.

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Williams CD, Bajt ML, Farhood A, Jaeschke H.

Liver Int. 2010 Oct;30(9):1280-92. doi: 10.1111/j.1478-3231.2010.02284.x.

10.

Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.

Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR.

Toxicol Sci. 2010 May;115(1):267-85. doi: 10.1093/toxsci/kfq034. Epub 2010 Feb 1.

11.

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.

Mobasher MA, González-Rodriguez A, Santamaría B, Ramos S, Martín MÁ, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martín-Pérez J, Simpson KJ, Muntané J, Valverde AM.

Cell Death Dis. 2013 May 9;4:e626. doi: 10.1038/cddis.2013.150.

12.

Activation of autophagy protects against acetaminophen-induced hepatotoxicity.

Ni HM, Bockus A, Boggess N, Jaeschke H, Ding WX.

Hepatology. 2012 Jan;55(1):222-32. doi: 10.1002/hep.24690. Epub 2011 Dec 6.

13.

Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis.

van Swelm RP, Laarakkers CM, Blous L, Peters JG, Blaney Davidson EN, van der Kraan PM, Swinkels DW, Masereeuw R, Russel FG.

Toxicol Sci. 2012 Sep;129(1):225-33. doi: 10.1093/toxsci/kfs176. Epub 2012 May 18.

14.

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice.

Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KS, Xu A.

Hepatology. 2014 Sep;60(3):977-89. doi: 10.1002/hep.27060. Epub 2014 Jul 25.

PMID:
24590984
15.

Complement activation in acetaminophen-induced liver injury in mice.

Singhal R, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2012 May;341(2):377-85. doi: 10.1124/jpet.111.189837. Epub 2012 Feb 7.

16.

Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice.

Wu YL, Jiang YZ, Jin XJ, Lian LH, Piao JY, Wan Y, Jin HR, Joon Lee J, Nan JX.

Phytomedicine. 2010 May;17(6):475-9. doi: 10.1016/j.phymed.2009.07.011.

PMID:
19836221
17.

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.

Yan HM, Ramachandran A, Bajt ML, Lemasters JJ, Jaeschke H.

Toxicol Sci. 2010 Oct;117(2):515-23. doi: 10.1093/toxsci/kfq208. Epub 2010 Jul 8.

18.

Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.

Mochizuki A, Pace A, Rockwell CE, Roth KJ, Chow A, O'Brien KM, Albee R, Kelly K, Towery K, Luyendyk JP, Copple BL.

J Immunol. 2014 Apr 15;192(8):3847-57. doi: 10.4049/jimmunol.1303195. Epub 2014 Mar 17.

19.

Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.

Williams CD, Farhood A, Jaeschke H.

Toxicol Appl Pharmacol. 2010 Sep 15;247(3):169-78. doi: 10.1016/j.taap.2010.07.004. Epub 2010 Jul 15.

20.

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Bajt ML, Ramachandran A, Yan HM, Lebofsky M, Farhood A, Lemasters JJ, Jaeschke H.

Toxicol Sci. 2011 Aug;122(2):598-605. doi: 10.1093/toxsci/kfr116. Epub 2011 May 13.

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