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Results: 1 to 20 of 191

1.

mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.

Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC.

Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16.

PMID:
21576368
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC.

Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1.

PMID:
19487463
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.

Wu D, Chapman JR, Wang L, Harris TE, Shabanowitz J, Hunt DF, Fu Z.

J Biol Chem. 2012 Apr 6;287(15):12510-9. doi: 10.1074/jbc.M111.302117. Epub 2012 Feb 22.

PMID:
22356909
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation.

Ramírez-Valle F, Badura ML, Braunstein S, Narasimhan M, Schneider RJ.

Mol Cell Biol. 2010 Jul;30(13):3151-64. doi: 10.1128/MCB.00322-09. Epub 2010 May 3.

PMID:
20439490
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC.

J Biol Chem. 2010 Jan 1;285(1):80-94. doi: 10.1074/jbc.M109.029637. Epub 2009 Oct 28.

PMID:
19864431
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes.

Tao Z, Barker J, Shi SD, Gehring M, Sun S.

Biochemistry. 2010 Oct 5;49(39):8488-98. doi: 10.1021/bi100673c. Epub 2010 Sep 8.

PMID:
20804212
[PubMed - indexed for MEDLINE]
7.

Raptor is phosphorylated by cdc2 during mitosis.

Gwinn DM, Asara JM, Shaw RJ.

PLoS One. 2010 Feb 12;5(2):e9197. doi: 10.1371/journal.pone.0009197.

PMID:
20169205
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A role for Raptor phosphorylation in the mechanical activation of mTOR signaling.

Frey JW, Jacobs BL, Goodman CA, Hornberger TA.

Cell Signal. 2014 Feb;26(2):313-22. doi: 10.1016/j.cellsig.2013.11.009. Epub 2013 Nov 13.

PMID:
24239769
[PubMed - indexed for MEDLINE]
9.

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding.

Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR.

Autophagy. 2011 Jul;7(7):737-47. Epub 2011 Jul 1.

PMID:
21460630
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

PMID:
17599906
[PubMed - indexed for MEDLINE]
Free Article
11.

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.

PMID:
23928304
[PubMed - indexed for MEDLINE]
12.

Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs).

Vazquez-Martin A, Cufí S, Oliveras-Ferraros C, Menendez JA.

Cell Cycle. 2011 Sep 15;10(18):3140-52. Epub 2011 Sep 15.

PMID:
21900751
[PubMed - indexed for MEDLINE]
Free Article
13.

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.

Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP.

Curr Biol. 2008 Sep 9;18(17):1269-77. doi: 10.1016/j.cub.2008.07.078. Epub 2008 Aug 21.

PMID:
18722121
[PubMed - indexed for MEDLINE]
Free Article
14.

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.

Wang L, Harris TE, Roth RA, Lawrence JC Jr.

J Biol Chem. 2007 Jul 6;282(27):20036-44. Epub 2007 May 17.

PMID:
17510057
[PubMed - indexed for MEDLINE]
Free Article
15.

Role of PRAS40 in Akt and mTOR signaling in health and disease.

Wiza C, Nascimento EB, Ouwens DM.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1453-60. doi: 10.1152/ajpendo.00660.2011. Epub 2012 Feb 21.

PMID:
22354785
[PubMed - indexed for MEDLINE]
Free Article
16.

Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).

Agrawal P, Chen YT, Schilling B, Gibson BW, Hughes RE.

J Biol Chem. 2012 Jun 15;287(25):21164-75. doi: 10.1074/jbc.M111.328021. Epub 2012 Apr 27.

PMID:
22544753
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

Coffman K, Yang B, Lu J, Tetlow AL, Pelliccio E, Lu S, Guo DC, Tang C, Dong MQ, Tamanoi F.

J Biol Chem. 2014 Feb 21;289(8):4723-34. doi: 10.1074/jbc.M113.482067. Epub 2014 Jan 8.

PMID:
24403073
[PubMed - indexed for MEDLINE]
18.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP.

J Biol Chem. 2011 Jan 7;286(1):567-77. doi: 10.1074/jbc.M110.159046. Epub 2010 Nov 11.

PMID:
21071439
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.

J Biol Chem. 2011 Nov 4;286(44):38043-53. doi: 10.1074/jbc.M111.245449. Epub 2011 Sep 13.

PMID:
21914810
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action.

Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC.

J Biol Chem. 2010 Mar 12;285(11):7866-79. doi: 10.1074/jbc.M109.096222. Epub 2009 Dec 18.

PMID:
20022946
[PubMed - indexed for MEDLINE]
Free PMC Article

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