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Items: 1 to 20 of 153

1.

Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization.

Authier S, Gervais J, Fournier S, Gauvin D, Maghezzi S, Troncy E.

J Pharmacol Toxicol Methods. 2011 Jul-Aug;64(1):53-9. doi: 10.1016/j.vascn.2011.04.007. Epub 2011 May 3.

PMID:
21570473
2.

A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 2: Pharmacological validation.

Authier S, Tanguay JF, Gauvin D, Fruscia RD, Troncy E.

J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):122-30. Epub 2007 May 24.

PMID:
17587605
3.

Validation of the normal, freely moving Göttingen minipig for pharmacological safety testing.

Markert M, Stubhan M, Mayer K, Trautmann T, Klumpp A, Schuler-Metz A, Schumacher K, Guth B.

J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):79-87. doi: 10.1016/j.vascn.2008.12.004. Epub 2009 May 8.

PMID:
19427912
4.

Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen Minipig.

Stubhan M, Markert M, Mayer K, Trautmann T, Klumpp A, Henke J, Guth B.

J Pharmacol Toxicol Methods. 2008 May-Jun;57(3):202-11. doi: 10.1016/j.vascn.2008.02.001. Epub 2008 Feb 29.

PMID:
18434212
5.

Cardiovascular parameters in anaesthetized guinea pigs: a safety pharmacology screening model.

Hauser DS, Stade M, Schmidt A, Hanauer G.

J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):106-14.

PMID:
15961325
6.

Comparison of freely-moving telemetry Chinese Miniature Experiment Pigs (CMEPs) to beagle dogs in cardiovascular safety pharmacology studies.

Yuan H, Zhao J, Guo J, Wu R, He L, Cui Y, Feng M, Zhang T, Hou M, Guo Q, Zhang L, Jia L, Huang C, Ye L, Peng S.

J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):19-28. doi: 10.1016/j.vascn.2014.03.172. Epub 2014 Apr 8.

PMID:
24721420
7.

QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation.

Kano M, Toyoshi T, Iwasaki S, Kato M, Shimizu M, Ota T.

J Pharmacol Sci. 2005;99(5):501-11.

8.

Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment.

Fryer RM, Ng KJ, Chi L, Jin X, Reinhart GA.

J Pharmacol Toxicol Methods. 2015 Jul-Aug;74:26-32. doi: 10.1016/j.vascn.2015.04.007. Epub 2015 May 3.

PMID:
25946685
9.

Cardiorespiratory safety evaluation in non-human primates.

Ingram-Ross JL, Curran AK, Miyamoto M, Sheehan J, Thomas G, Verbeeck J, de Waal EJ, Verstynen B, Pugsley MK.

J Pharmacol Toxicol Methods. 2012 Sep;66(2):114-24. doi: 10.1016/j.vascn.2012.04.002. Epub 2012 Apr 12.

PMID:
22521338
10.

Dose-response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys.

Lynch JJ 3rd, Wilson AW, Hernandez LE, Nelson RA, Marsh KC, Cox BF, Mittelstadt SW.

Br J Pharmacol. 2008 Aug;154(7):1439-45. doi: 10.1038/bjp.2008.206. Epub 2008 Jun 2.

11.

Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP).

Kremer JJ, Bills AJ, Hanke NJ, Chen H, Meier WA, Osinski MA, Foley CM.

J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:27-37. doi: 10.1016/j.vascn.2015.05.008. Epub 2015 May 20.

PMID:
26001324
12.

Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: invasive LVP measurements versus the QA interval.

Johnson DM, Geys R, Lissens J, Guns PJ.

J Pharmacol Toxicol Methods. 2012 Sep;66(2):152-9. doi: 10.1016/j.vascn.2012.07.002. Epub 2012 Jul 17.

PMID:
22813982
13.

Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies.

Kim TW, Kim KS, Seo JW, Park SY, Henry SP.

J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):49-60. doi: 10.1016/j.vascn.2013.10.005. Epub 2013 Nov 8.

14.

Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.

Derakhchan K, Chui RW, Stevens D, Gu W, Vargas HM.

Br J Pharmacol. 2014 Jan;171(2):509-22. doi: 10.1111/bph.12484.

15.

The minipig in toxicology.

Svendsen O.

Exp Toxicol Pathol. 2006 Jul;57(5-6):335-9. Epub 2006 May 24.

PMID:
16725317
16.

Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys.

Authier S, Haefner P, Fournier S, Troncy E, Moon LB.

J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):6-11. doi: 10.1016/j.vascn.2010.05.014. Epub 2010 Jun 4.

PMID:
20570745
17.

Intravenous solid tip ECG lead placement in telemetry implanted dogs: Part 2: High quality telemetry signals yield high sensitivity to drug-induced changes.

Mitchell AZ, Bills AJ, Wittwer GT, Foley CM, Kremer JJ, Chen H, Osinski MA.

J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):62-73. doi: 10.1016/j.vascn.2013.04.006. Epub 2013 Apr 29.

PMID:
23639348
18.

Calculation of QT shift in non clinical safety pharmacology studies.

Champeroux P, Martel E, Fowler JS, Maurin A, Sola ML, Jude S, Elamrani F, Weyn AA, Laveissiere A, Lala P, Richard S.

J Pharmacol Toxicol Methods. 2009 Mar-Apr;59(2):73-85. doi: 10.1016/j.vascn.2008.11.001. Epub 2008 Dec 10.

PMID:
19135537
19.

Respiratory mechanics: comparison of Beagle dogs, Göttingen minipigs and Cynomolgus monkeys.

Truchetti G, Troncy E, Robichaud A, Gold L, Schuessler T, Maghezzi S, Bassett L, Authier S.

J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):48-54. doi: 10.1016/j.vascn.2014.03.171. Epub 2014 Apr 1.

PMID:
24704341
20.

A multi-site comparison of in vivo safety pharmacology studies conducted to support ICH S7A & B regulatory submissions.

Ewart L, Milne A, Adkins D, Benjamin A, Bialecki R, Chen Y, Ericsson AC, Gardner S, Grant C, Lengel D, Lindgren S, Lowing S, Marks L, Moors J, Oldman K, Pietras M, Prior H, Punton J, Redfern WS, Salmond R, Skinner M, Some M, Stanton A, Swedberg M, Finch J, Valentin JP.

J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):30-43. doi: 10.1016/j.vascn.2013.04.008. Epub 2013 May 9.

PMID:
23665080
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