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Items: 1 to 20 of 134

1.

Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.

Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2011 Jul 8;286(27):23888-99. doi: 10.1074/jbc.M111.245969. Epub 2011 May 12.

2.
3.

Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.

Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2008 Aug;74(2):413-22. doi: 10.1124/mol.108.047209. Epub 2008 May 8.

4.

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.

Dong M, Xu X, Ball AM, Makhoul JA, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

FASEB J. 2012 Dec;26(12):5092-105. doi: 10.1096/fj.12-212399. Epub 2012 Sep 10.

5.

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.

Dong M, Te JA, Xu X, Wang J, Pinon DI, Storjohann L, Bordner AJ, Miller LJ.

Biochemistry. 2011 Sep 27;50(38):8181-92. doi: 10.1021/bi2008036. Epub 2011 Aug 30.

6.

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints.

Dong M, Pinon DI, Bordner AJ, Miller LJ.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6040-4. doi: 10.1016/j.bmcl.2010.08.062. Epub 2010 Aug 15.

7.

Differential spatial approximation between secretin and its receptor residues in active and inactive conformations demonstrated by photoaffinity labeling.

Dong M, Hosohata K, Pinon DI, Muthukumaraswamy N, Miller LJ.

Mol Endocrinol. 2006 Jul;20(7):1688-98. Epub 2006 Mar 2.

PMID:
16513792
8.

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2010 Mar 26;285(13):9919-31. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25.

10.

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.

Miller LJ, Dong M, Harikumar KG, Gao F.

Biochem Soc Trans. 2007 Aug;35(Pt 4):709-12. Review.

PMID:
17635130
11.
12.

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2007 Aug;72(2):280-90. Epub 2007 May 2.

13.
14.

Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity.

Dong M, Pinon DI, Miller LJ.

Regul Pept. 2013 Jan 10;180:5-11. doi: 10.1016/j.regpep.2012.10.001. Epub 2012 Nov 8.

15.

Identification of two pairs of spatially approximated residues within the carboxyl terminus of secretin and its receptor.

Dong M, Asmann YW, Zang M, Pinon DI, Miller LJ.

J Biol Chem. 2000 Aug 25;275(34):26032-9.

16.

Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.

Miller LJ, Dong M, Harikumar KG.

Br J Pharmacol. 2012 May;166(1):18-26. doi: 10.1111/j.1476-5381.2011.01463.x. Review.

17.

Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.

Dong M, Li Z, Pinon DI, Lybrand TP, Miller LJ.

J Biol Chem. 2004 Jan 23;279(4):2894-903. Epub 2003 Oct 30.

18.

Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.

Dong M, Zang M, Pinon DI, Li Z, Lybrand TP, Miller LJ.

Mol Endocrinol. 2002 Nov;16(11):2490-501.

PMID:
12403838
20.

Importance of each residue within secretin for receptor binding and biological activity.

Dong M, Le A, Te JA, Pinon DI, Bordner AJ, Miller LJ.

Biochemistry. 2011 Apr 12;50(14):2983-93. doi: 10.1021/bi200133u. Epub 2011 Mar 21.

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