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Results: 1 to 20 of 102

1.

IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration.

Jaquish DV, Yu PT, Shields DJ, French RP, Maruyama KP, Niessen S, Hoover H, A Cheresh D, Cravatt B, Lowy AM.

Carcinogenesis. 2011 Aug;32(8):1151-6. doi: 10.1093/carcin/bgr086. Epub 2011 May 11.

PMID:
21565828
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome.

Yu PT, Babicky M, Jaquish D, French R, Marayuma K, Mose E, Niessen S, Hoover H, Shields D, Cheresh D, Cravatt BF, Lowy AM.

Int J Cancer. 2012 Oct 15;131(8):1744-54. doi: 10.1002/ijc.27447. Epub 2012 Mar 8.

PMID:
22275185
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells.

Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN.

Carcinogenesis. 2008 Jun;29(6):1096-107. doi: 10.1093/carcin/bgn026. Epub 2008 Feb 7.

PMID:
18263593
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target.

Camp ER, Yang A, Gray MJ, Fan F, Hamilton SR, Evans DB, Hooper AT, Pereira DS, Hicklin DJ, Ellis LM.

Cancer. 2007 Mar 15;109(6):1030-9.

PMID:
17311308
[PubMed - indexed for MEDLINE]
Free Article
5.

Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi).

Zou Y, Howell GM, Humphrey LE, Wang J, Brattain MG.

PLoS One. 2013 Jul 29;8(7):e69992. doi: 10.1371/journal.pone.0069992. Print 2013.

PMID:
23922886
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.

Logan-Collins J, Thomas RM, Yu P, Jaquish D, Mose E, French R, Stuart W, McClaine R, Aronow B, Hoffman RM, Waltz SE, Lowy AM.

Cancer Res. 2010 Feb 1;70(3):1130-40. doi: 10.1158/0008-5472.CAN-09-0761. Epub 2010 Jan 26.

PMID:
20103639
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies.

Kang CM, Babicky ML, Lowy AM.

Pancreas. 2014 Mar;43(2):183-9. doi: 10.1097/MPA.0000000000000088. Review.

PMID:
24518495
[PubMed - indexed for MEDLINE]
8.

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.

Potratz JC, Saunders DN, Wai DH, Ng TL, McKinney SE, Carboni JM, Gottardis MM, Triche TJ, J├╝rgens H, Pollak MN, Aparicio SA, Sorensen PH.

Cancer Res. 2010 Nov 1;70(21):8770-81. doi: 10.1158/0008-5472.CAN-10-1093. Epub 2010 Oct 19.

PMID:
20959493
[PubMed - indexed for MEDLINE]
Free Article
9.

Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells.

Wu YC, Zhu M, Robertson DM.

PLoS One. 2012;7(8):e42483. doi: 10.1371/journal.pone.0042483. Epub 2012 Aug 3.

PMID:
22879999
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.

Thomas RM, Toney K, Fenoglio-Preiser C, Revelo-Penafiel MP, Hingorani SR, Tuveson DA, Waltz SE, Lowy AM.

Cancer Res. 2007 Jul 1;67(13):6075-82.

PMID:
17616662
[PubMed - indexed for MEDLINE]
Free Article
12.

Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein.

Ma Q, Guin S, Padhye SS, Zhou YQ, Zhang RW, Wang MH.

Mol Cancer. 2011 May 28;10:66. doi: 10.1186/1476-4598-10-66.

PMID:
21619683
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.

Zhao S, Ammanamanchi S, Brattain M, Cao L, Thangasamy A, Wang J, Freeman JW.

J Biol Chem. 2008 Apr 25;283(17):11293-301. doi: 10.1074/jbc.M800154200. Epub 2008 Feb 29.

PMID:
18310076
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.

Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B.

Breast Cancer Res. 2011 May 19;13(3):R52. doi: 10.1186/bcr2883.

PMID:
21595894
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.

Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7055-60. doi: 10.1073/pnas.1118359109. Epub 2012 Apr 16.

PMID:
22509025
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.

Castro NE, Lange CA.

Breast Cancer Res. 2010;12(4):R60. doi: 10.1186/bcr2622. Epub 2010 Aug 5.

PMID:
20687930
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Small interfering RNA-directed targeting of RON alters invasive and oncogenic phenotypes of human hepatocellular carcinoma cells.

Cho SB, Park YL, Song YA, Kim KY, Lee GH, Cho DH, Myung DS, Park KJ, Lee WS, Chung IJ, Choi SK, Kim KK, Joo YE.

Oncol Rep. 2011 Dec;26(6):1581-6. doi: 10.3892/or.2011.1435. Epub 2011 Aug 24.

PMID:
21874262
[PubMed - indexed for MEDLINE]
18.

Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.

Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, Dixon D.

Mol Med. 2008 May-Jun;14(5-6):264-75. doi: 10.2119/2007-00101.Yu. Erratum in: Mol Med. 2008 Jul-Aug;14(7-8):538.

PMID:
18231572
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells.

Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Takeyama H.

J Surg Res. 2010 May 1;160(1):90-101. doi: 10.1016/j.jss.2008.08.016. Epub 2008 Sep 13.

PMID:
19560785
[PubMed - indexed for MEDLINE]
20.

Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo.

Zhang Y, Kaplan-Lefko PJ, Rex K, Yang Y, Moriguchi J, Osgood T, Mattson B, Coxon A, Reese M, Kim TS, Lin J, Chen A, Burgess TL, Dussault I.

Cancer Res. 2008 Aug 15;68(16):6680-7. doi: 10.1158/0008-5472.CAN-07-6782.

PMID:
18701492
[PubMed - indexed for MEDLINE]
Free Article

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