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Inhibition of cellular FLICE-like inhibitory protein abolishes insensitivity to interferon-α and death receptor stimulation in resistant variants of the human U937 cell line.

Blomberg J, Höglund A, Eriksson D, Ruuth K, Jacobsson M, Lundgren E, Nilsson JA.

Apoptosis. 2011 Aug;16(8):783-94. doi: 10.1007/s10495-011-0606-0.


Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.

Siegmund D, Mauri D, Peters N, Juo P, Thome M, Reichwein M, Blenis J, Scheurich P, Tschopp J, Wajant H.

J Biol Chem. 2001 Aug 31;276(35):32585-90. Epub 2001 May 30.


Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma.

Okano H, Shiraki K, Inoue H, Kawakita T, Yamanaka T, Deguchi M, Sugimoto K, Sakai T, Ohmori S, Fujikawa K, Murata K, Nakano T.

Lab Invest. 2003 Jul;83(7):1033-43.


cFLIP regulates death receptor-mediated apoptosis in an ovarian granulosa cell line by inhibiting procaspase-8 cleavage.

Matsuda F, Inoue N, Goto Y, Maeda A, Cheng Y, Sakamaki K, Manabe N.

J Reprod Dev. 2008 Oct;54(5):314-20. Epub 2008 Jul 7.


Acquired resistance to Fas/CD95 ligation in U937 cells is associated with multiple molecular mechanisms.

Blomberg J, Ruuth K, Santos D, Lundgren E.

Anticancer Res. 2008 Mar-Apr;28(2A):593-9.


Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis.

Fluhr H, Krenzer S, Stein GM, Stork B, Deperschmidt M, Wallwiener D, Wesselborg S, Zygmunt M, Licht P.

J Cell Sci. 2007 Dec 1;120(Pt 23):4126-33. Epub 2007 Nov 14.


Unique resistance of breast carcinoma cell line T47D to TRAIL but not anti-Fas is linked to p43cFLIP(L).

Guseva NV, Rokhlin OW, Taghiyev AF, Cohen MB.

Breast Cancer Res Treat. 2008 Feb;107(3):349-57. Epub 2007 Apr 24.


Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.

Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH, Walczak H.

Cell Death Differ. 2004 Jul;11 Suppl 1:S86-96.


Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP.

Oh HY, Namkoong S, Lee SJ, Por E, Kim CK, Billiar TR, Han JA, Ha KS, Chung HT, Kwon YG, Lee H, Kim YM.

Cell Death Differ. 2006 Mar;13(3):512-23.


Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency.

van Blitterswijk WJ, Klarenbeek JB, van der Luit AH, Alderliesten MC, van Lummel M, Verheij M.

Biochem J. 2009 Dec 14;425(1):225-34. doi: 10.1042/BJ20090455.


Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD).

Wajant H, Haas E, Schwenzer R, Muhlenbeck F, Kreuz S, Schubert G, Grell M, Smith C, Scheurich P.

J Biol Chem. 2000 Aug 11;275(32):24357-66.


High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells.

Jönsson G, Paulie S, Grandien A.

Anticancer Res. 2003 Mar-Apr;23(2B):1213-8.


Chemical sensitization and regulation of TRAIL-induced apoptosis in a panel of B-lymphocytic leukaemia cell lines.

Kang J, Kisenge RR, Toyoda H, Tanaka S, Bu J, Azuma E, Komada Y.

Br J Haematol. 2003 Dec;123(5):921-32.


Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers.

Nam SY, Jung GA, Hur GC, Chung HY, Kim WH, Seol DW, Lee BL.

Cancer Sci. 2003 Dec;94(12):1066-73.


Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP.

Wang W, Fang Y, Sima N, Li Y, Li W, Li L, Han L, Liao S, Han Z, Gao Q, Li K, Deng D, Meng L, Zhou J, Wang S, Ma D.

Apoptosis. 2011 Jan;16(1):55-66. doi: 10.1007/s10495-010-0543-3.

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