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Items: 1 to 20 of 94

1.
2.

Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.

Bourdi M, Korrapati MC, Chakraborty M, Yee SB, Pohl LR.

Biochem Biophys Res Commun. 2008 Sep 12;374(1):6-10. doi: 10.1016/j.bbrc.2008.06.065. Epub 2008 Jun 27.

3.

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N.

Gastroenterology. 2006 Jul;131(1):165-78.

PMID:
16831600
4.

What is your diagnosis? Serum biochemical data from genetically modified mice.

Irizarry Rovira AR, Gao H, Jolly RA, Raub TJ.

Vet Clin Pathol. 2012 Jun;41(2):301-2. doi: 10.1111/j.1939-165X.2012.00428.x. Epub 2012 May 2. No abstract available.

PMID:
22551217
5.

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.

Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M.

Gastroenterology. 2008 Oct;135(4):1311-21. doi: 10.1053/j.gastro.2008.07.006. Epub 2008 Jul 9.

PMID:
18700144
6.

Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.

Ryan PM, Bourdi M, Korrapati MC, Proctor WR, Vasquez RA, Yee SB, Quinn TD, Chakraborty M, Pohl LR.

Chem Res Toxicol. 2012 Jan 13;25(1):83-93. doi: 10.1021/tx2003992. Epub 2011 Dec 13.

7.

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O.

J Hepatol. 2013 Sep;59(3):495-503. doi: 10.1016/j.jhep.2013.04.024. Epub 2013 May 9.

PMID:
23665281
8.

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Williams CD, Bajt ML, Farhood A, Jaeschke H.

Liver Int. 2010 Oct;30(9):1280-92. doi: 10.1111/j.1478-3231.2010.02284.x.

9.

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators.

Gardner CR, Laskin JD, Dambach DM, Chiu H, Durham SK, Zhou P, Bruno M, Gerecke DR, Gordon MK, Laskin DL.

Toxicol Appl Pharmacol. 2003 Oct 15;192(2):119-30.

PMID:
14550746
10.

Highly expressed protein kinase A inhibitor α and suppression of protein kinase A may potentiate acetaminophen-induced hepatotoxicity.

Yun JW, Kim M, Cho SD, Lee JY, Bae ON, Lim KM.

Toxicol Lett. 2014 Aug 17;229(1):59-65. doi: 10.1016/j.toxlet.2014.06.010. Epub 2014 Jun 6.

PMID:
24910983
11.

Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.

Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR.

Toxicol Sci. 2010 May;115(1):267-85. doi: 10.1093/toxsci/kfq034. Epub 2010 Feb 1.

12.

Influence of small doses of various drug vehicles on acetaminophen-induced liver injury.

Kelava T, Cavar I, Culo F.

Can J Physiol Pharmacol. 2010 Oct;88(10):960-7. doi: 10.1139/y10-065.

PMID:
20962895
13.

Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production.

Dragomir AC, Sun R, Mishin V, Hall LB, Laskin JD, Laskin DL.

Toxicol Sci. 2012 Jun;127(2):609-19. doi: 10.1093/toxsci/kfs117. Epub 2012 Mar 29.

14.

Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.

Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA.

J Pharmacol Exp Ther. 2012 Jan;340(1):134-42. doi: 10.1124/jpet.111.184192. Epub 2011 Oct 14.

15.

Acetaminophen-induced acute liver injury in HCV transgenic mice.

Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):224-32. doi: 10.1016/j.taap.2012.11.019. Epub 2012 Nov 29.

16.

Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.

Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I.

Toxicol Appl Pharmacol. 2015 Jan 15;282(2):195-206. doi: 10.1016/j.taap.2014.11.015. Epub 2014 Dec 10.

PMID:
25499718
17.

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice.

Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KS, Xu A.

Hepatology. 2014 Sep;60(3):977-89. doi: 10.1002/hep.27060. Epub 2014 Jul 25.

PMID:
24590984
18.

Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity.

Liu J, Liu Y, Hartley D, Klaassen CD, Shehin-Johnson SE, Lucas A, Cohen SD.

J Pharmacol Exp Ther. 1999 Apr;289(1):580-6.

19.

Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.

Bajt ML, Yan HM, Farhood A, Jaeschke H.

Toxicol Sci. 2008 Aug;104(2):419-27. doi: 10.1093/toxsci/kfn091. Epub 2008 May 9.

20.

How relevant are neutrophils for acetaminophen hepatotoxicity?

Jaeschke H.

Hepatology. 2006 Jun;43(6):1191-4. No abstract available.

PMID:
16729330
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