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The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial.

Snijders GF, van den Ende CH, van Riel PL, van den Hoogen FH, den Broeder AA; NOAC study group.

Ann Rheum Dis. 2011 Jul;70(7):1191-6. doi: 10.1136/ard.2010.147967. Epub 2011 May 8.


Why should we expect a structure-modifying osteoarthritis drug to relieve osteoarthritis pain?

Brandt KD.

Ann Rheum Dis. 2011 Jul;70(7):1175-7. doi: 10.1136/ard.2011.150953. No abstract available.


Doxycycline for osteoarthritis of the knee or hip.

Nüesch E, Rutjes AW, Trelle S, Reichenbach S, Jüni P.

Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007323. doi: 10.1002/14651858.CD007323.pub2. Review. Update in: Cochrane Database Syst Rev. 2012;11:CD007323.


Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in obese women with knee osteoarthritis.

Mazzuca SA, Brandt KD, Schauwecker DS, Katz BP, Meyer JM, Lane KA, Bradley JD, Hugenberg ST, Wolfe F, Moreland LW, Heck LW, Yocum DE, Schnitzer TJ, Sharma L, Manzi S, Oddis CV.

J Rheumatol. 2005 Aug;32(8):1540-6.


The randomized clinical trial of doxycycline in knee osteoarthritis: comment on the editorial by Dieppe.

Brandt KD, Mazzuca SA.

Arthritis Rheum. 2006 Feb;54(2):684. No abstract available.


Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial.

Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, Wolfe F, Schnitzer TJ, Moreland LW, Manzi S, Bradley JD, Sharma L, Oddis CV, Hugenberg ST, Heck LW.

Arthritis Rheum. 2005 Jul;52(7):2015-25.


Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.

Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ.

N Engl J Med. 2006 Feb 23;354(8):795-808.


Lessons learned from nine clinical trials of disease-modifying osteoarthritis drugs.

Brandt KD, Mazzuca SA.

Arthritis Rheum. 2005 Nov;52(11):3349-59. Review. No abstract available.


Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.

Raynauld JP, Martel-Pelletier J, Bias P, Laufer S, Haraoui B, Choquette D, Beaulieu AD, Abram F, Dorais M, Vignon E, Pelletier JP; Canadian Licofelone Study Group.

Ann Rheum Dis. 2009 Jun;68(6):938-47. doi: 10.1136/ard.2008.088732. Epub 2008 Jul 23.


Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI.

Wildi LM, Raynauld JP, Martel-Pelletier J, Abram F, Dorais M, Pelletier JP.

Ann Rheum Dis. 2010 Dec;69(12):2118-24. doi: 10.1136/ard.2009.127993. Epub 2010 Jul 7.


Subject retention and adherence in a randomized placebo-controlled trial of a disease-modifying osteoarthritis drug.

Mazzuca SA, Brandt KD, Katz BP, Lane KA, Bradley JD, Heck LW, Hugenberg ST, Manzi S, Moreland LW, Oddis CV, Schnitzer TJ, Sharma L, Wolfe F, Yocum DE.

Arthritis Rheum. 2004 Dec 15;51(6):933-40.


Total joint replacement of hip or knee as an outcome measure for structure modifying trials in osteoarthritis.

Altman RD, Abadie E, Avouac B, Bouvenot G, Branco J, Bruyere O, Calvo G, Devogelaer JP, Dreiser RL, Herrero-Beaumont G, Kahan A, Kreutz G, Laslop A, Lemmel EM, Menkes CJ, Pavelka K, Van De Putte L, Vanhaelst L, Reginster JY; Group for Respect of Excellence and Ethics in Science (GREES).

Osteoarthritis Cartilage. 2005 Jan;13(1):13-9. Review.


Effectiveness of diclofenac versus acetaminophen in primary care patients with knee osteoarthritis: [NTR1485], DIPA-trial: design of a randomized clinical trial.

Verkleij SP, Luijsterburg PA, Koes BW, Bohnen AM, Bierma-Zeinstra SM.

BMC Musculoskelet Disord. 2010 Jan 12;11:7. doi: 10.1186/1471-2474-11-7.


The effect of acupuncture on the symptoms of knee osteoarthritis--an open randomised controlled study.

Tukmachi E, Jubb R, Dempsey E, Jones P.

Acupunct Med. 2004 Mar;22(1):14-22.


Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study.

Möller I, Pérez M, Monfort J, Benito P, Cuevas J, Perna C, Doménech G, Herrero M, Montell E, Vergés J.

Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S32-40. doi: 10.1016/j.joca.2010.01.018. Epub 2010 May 10.


Efficacy, safety, and tolerability of the cyclooxygenase-inhibiting nitric oxide donator naproxcinod in treating osteoarthritis of the hip or knee.

Karlsson J, Pivodic A, Aguirre D, Schnitzer TJ.

J Rheumatol. 2009 Jun;36(6):1290-7. doi: 10.3899/jrheum.081011. Epub 2009 May 1.

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