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Items: 1 to 20 of 118

1.

1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.

Micheli F, Cavanni P, Bettati M, Bonanomi G, Di Fabio R, Fazzolari E, Marchioro C, Roscic M, Tarsi L, Visentini F, Zonzini L, Worby A.

Bioorg Med Chem. 2011 Jun 1;19(11):3451-61. doi: 10.1016/j.bmc.2011.04.032. Epub 2011 Apr 22.

PMID:
21550808
2.

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.

Micheli F, Cavanni P, Andreotti D, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Carletti R, Checchia A, Corsi M, Fazzolari E, Fontana S, Marchioro C, Merlo-Pich E, Negri M, Oliosi B, Ratti E, Read KD, Roscic M, Sartori I, Spada S, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L, Di Fabio R.

J Med Chem. 2010 Jul 8;53(13):4989-5001. doi: 10.1021/jm100481d.

PMID:
20527970
3.

Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.

Gong PK, Blough BE, Brieaddy LE, Huang X, Kuhar MJ, Navarro HA, Carroll FI.

J Med Chem. 2007 Jul 26;50(15):3686-95. Epub 2007 Jun 30.

PMID:
17602602
4.

Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.

Park JE, Song C, Choi K, Sim T, Moon B, Roh EJ.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5515-8. doi: 10.1016/j.bmcl.2013.08.062. Epub 2013 Aug 26.

PMID:
24012181
5.

Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.

Andrews M, Brown A, Chiva JY, Fradet D, Gordon D, Lansdell M, MacKenny M.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. doi: 10.1016/j.bmcl.2009.08.066. Epub 2009 Aug 21.

PMID:
19740658
6.

Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.

Greiner E, Boos TL, Prisinzano TE, De Martino MG, Zeglis B, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC.

J Med Chem. 2006 Mar 9;49(5):1766-72.

PMID:
16509591
7.
8.

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.

Pechulis AD, Beck JP, Curry MA, Wolf MA, Harms AE, Xi N, Opalka C, Sweet MP, Yang Z, Vellekoop AS, Klos AM, Crocker PJ, Hassler C, Laws M, Kitchen DB, Smith MA, Olson RE, Liu S, Molino BF.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7219-22. doi: 10.1016/j.bmcl.2012.09.050. Epub 2012 Sep 25.

PMID:
23084899
9.

Oxa-azaspiro derivatives: a novel class of triple re-uptake inhibitors.

Bettati M, Cavanni P, Di Fabio R, Oliosi B, Perini O, Scheid G, Tedesco G, Zonzini L, Micheli F.

ChemMedChem. 2010 Mar 1;5(3):361-6. doi: 10.1002/cmdc.200900482. No abstract available.

PMID:
20112329
10.

The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.

Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):48-51. doi: 10.1016/j.bmcl.2010.11.076. Epub 2010 Nov 21.

11.

Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.

Carroll FI, Blough BE, Abraham P, Mills AC, Holleman JA, Wolckenhauer SA, Decker AM, Landavazo A, McElroy KT, Navarro HA, Gatch MB, Forster MJ.

J Med Chem. 2009 Nov 12;52(21):6768-81. doi: 10.1021/jm901189z.

PMID:
19821577
12.
14.

Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.

Torun L, Madras BK, Meltzer PC.

Bioorg Med Chem. 2012 Apr 15;20(8):2762-72. doi: 10.1016/j.bmc.2012.01.053. Epub 2012 Feb 8.

15.

Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.

Banister SD, Moussa IA, Beinat C, Reynolds AJ, Schiavini P, Jorgensen WT, Kassiou M.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):38-41. doi: 10.1016/j.bmcl.2010.11.075. Epub 2010 Nov 21.

PMID:
21146989
16.

Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.

Shao L, Ma J, Wang F, Malcolm SC, Hewitt MC, Campbell UC, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):520-3. doi: 10.1016/j.bmcl.2010.10.086. Epub 2010 Oct 28.

PMID:
21095126
17.

Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.

Tamiz AP, Zhang J, Flippen-Anderson JL, Zhang M, Johnson KM, Deschaux O, Tella S, Kozikowski AP.

J Med Chem. 2000 Mar 23;43(6):1215-22.

PMID:
10737754
18.

Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.

Mahaney PE, Kim CY, Coghlan RD, Cohn ST, Heffernan GD, Huselton CA, Terefenko EA, Vu AT, Zhang P, Burroughs KD, Cosmi SA, Bray JA, Johnston GH, Deecher DC, Trybulski EJ.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5807-10. doi: 10.1016/j.bmcl.2009.07.050. Epub 2009 Aug 25.

PMID:
19713106
19.

Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.

Mahaney PE, Vu AT, McComas CC, Zhang P, Nogle LM, Watts WL, Sarkahian A, Leventhal L, Sullivan NR, Uveges AJ, Trybulski EJ.

Bioorg Med Chem. 2006 Dec 15;14(24):8455-66. Epub 2006 Sep 14.

PMID:
16973367
20.

The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.

Angus D, Bingham M, Buchanan D, Dunbar N, Gibson L, Goodwin R, Haunsø A, Houghton A, Huggett M, Morphy R, Napier S, Nimz O, Passmore J, Walker G.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):271-5. doi: 10.1016/j.bmcl.2010.11.021. Epub 2010 Nov 6.

PMID:
21112782
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