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Results: 1 to 20 of 160

1.

Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.

Duysen EG, Lockridge O.

Drug Metab Dispos. 2011 Aug;39(8):1321-3. doi: 10.1124/dmd.111.039917. Epub 2011 May 3.

PMID:
21540357
[PubMed - indexed for MEDLINE]
Free Article
2.

The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease.

Duysen EG, Li B, Lockridge O.

Expert Opin Drug Metab Toxicol. 2009 May;5(5):523-8. doi: 10.1517/17425250902915555 . Review.

PMID:
19416087
[PubMed - indexed for MEDLINE]
3.

Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice.

Duysen EG, Li B, Carlson M, Li YF, Wieseler S, Hinrichs SH, Lockridge O.

Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):514-21. doi: 10.1111/j.1742-7843.2008.00259.x.

PMID:
19067679
[PubMed - indexed for MEDLINE]
4.

The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency.

Li B, Duysen EG, Carlson M, Lockridge O.

J Pharmacol Exp Ther. 2008 Mar;324(3):1146-54. Epub 2007 Dec 4.

PMID:
18056867
[PubMed - indexed for MEDLINE]
Free Article
6.

Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma.

Li B, Sedlacek M, Manoharan I, Boopathy R, Duysen EG, Masson P, Lockridge O.

Biochem Pharmacol. 2005 Nov 25;70(11):1673-84. Epub 2005 Oct 6.

PMID:
16213467
[PubMed - indexed for MEDLINE]
7.

Therapeutic use of butyrylcholinesterase for cocaine intoxication.

Mattes CE, Lynch TJ, Singh A, Bradley RM, Kellaris PA, Brady RO, Dretchen KL.

Toxicol Appl Pharmacol. 1997 Aug;145(2):372-80.

PMID:
9266811
[PubMed - indexed for MEDLINE]
8.

Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans.

Carmona GN, Jufer RA, Goldberg SR, Gorelick DA, Greig NH, Yu QS, Cone EJ, Schindler CW.

Drug Metab Dispos. 2000 Mar;28(3):367-71.

PMID:
10681384
[PubMed - indexed for MEDLINE]
Free Article
9.

The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma.

Browne SP, Slaughter EA, Couch RA, Rudnic EM, McLean AM.

Biopharm Drug Dispos. 1998 Jul;19(5):309-14.

PMID:
9673783
[PubMed - indexed for MEDLINE]
10.

Gene-delivered butyrylcholinesterase is prophylactic against the toxicity of chemical warfare nerve agents and organophosphorus compounds.

Parikh K, Duysen EG, Snow B, Jensen NS, Manne V, Lockridge O, Chilukuri N.

J Pharmacol Exp Ther. 2011 Apr;337(1):92-101. doi: 10.1124/jpet.110.175646. Epub 2010 Dec 28.

PMID:
21205915
[PubMed - indexed for MEDLINE]
Free Article
11.
12.

Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.

Xue L, Ko MC, Tong M, Yang W, Hou S, Fang L, Liu J, Zheng F, Woods JH, Tai HH, Zhan CG.

Mol Pharmacol. 2011 Feb;79(2):290-7. doi: 10.1124/mol.110.068494. Epub 2010 Oct 22.

PMID:
20971807
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy.

Gorelick DA.

Drug Alcohol Depend. 1997 Dec 15;48(3):159-65. Review.

PMID:
9449014
[PubMed - indexed for MEDLINE]
14.

Production of the butyrylcholinesterase knockout mouse.

Li B, Duysen EG, Saunders TL, Lockridge O.

J Mol Neurosci. 2006;30(1-2):193-5.

PMID:
17192674
[PubMed - indexed for MEDLINE]
15.

Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo.

Chilukuri N, Duysen EG, Parikh K, Sun W, Doctor BP, Lockridge O, Saxena A.

Chem Biol Interact. 2008 Sep 25;175(1-3):327-31. doi: 10.1016/j.cbi.2008.04.009. Epub 2008 May 21.

PMID:
18499092
[PubMed - indexed for MEDLINE]
16.

Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase.

Carmona GN, Schindler CW, Shoaib M, Jufer R, Cone EJ, Goldberg SR, Greig NH, Yu QS, Gorelick DA.

Exp Clin Psychopharmacol. 1998 Aug;6(3):274-9.

PMID:
9725111
[PubMed - indexed for MEDLINE]
17.

Cocaine detoxification by human plasma butyrylcholinesterase.

Lynch TJ, Mattes CE, Singh A, Bradley RM, Brady RO, Dretchen KL.

Toxicol Appl Pharmacol. 1997 Aug;145(2):363-71.

PMID:
9266810
[PubMed - indexed for MEDLINE]
18.

Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase.

Gatley SJ.

Biochem Pharmacol. 1991 Apr 15;41(8):1249-54.

PMID:
2009099
[PubMed - indexed for MEDLINE]
19.

An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.

Xie W, Altamirano CV, Bartels CF, Speirs RJ, Cashman JR, Lockridge O.

Mol Pharmacol. 1999 Jan;55(1):83-91.

PMID:
9882701
[PubMed - indexed for MEDLINE]
Free Article
20.

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.

Wang Y, Boeck AT, Duysen EG, Van Keuren M, Saunders TL, Lockridge O.

Toxicol Appl Pharmacol. 2004 May 1;196(3):356-66.

PMID:
15094306
[PubMed - indexed for MEDLINE]

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