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Results: 1 to 20 of 111

1.

New C15-substituted active vitamin D3.

Shindo K, Kumagai G, Takano M, Sawada D, Saito N, Saito H, Kakuda S, Takagi K, Ochiai E, Horie K, Takimoto-Kamimura M, Ishizuka S, Takenouchi K, Kittaka A.

Org Lett. 2011 Jun 3;13(11):2852-5. doi: 10.1021/ol200828s. Epub 2011 May 3.

PMID:
21539305
[PubMed - indexed for MEDLINE]
2.

Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide.

Vanhooke JL, Benning MM, Bauer CB, Pike JW, DeLuca HF.

Biochemistry. 2004 Apr 13;43(14):4101-10.

PMID:
15065852
[PubMed - indexed for MEDLINE]
3.

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs.

Takayama H, Kittaka A, Fujishima T, Suhara Y.

Recent Results Cancer Res. 2003;164:289-317. Review.

PMID:
12899530
[PubMed - indexed for MEDLINE]
4.

New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues.

Sicinski RR, Prahl JM, Smith CM, DeLuca HF.

J Med Chem. 1998 Nov 5;41(23):4662-74.

PMID:
9804706
[PubMed - indexed for MEDLINE]
5.

Highly potent cell differentiation-inducing analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D3 with side-chain modifications.

Fujishima T, Zhaopeng L, Konno K, Nakagawa K, Okano T, Yamaguchi K, Takayama H.

Bioorg Med Chem. 2001 Feb;9(2):525-35.

PMID:
11249144
[PubMed - indexed for MEDLINE]
6.

Synthesis and biological activities of new 1alpha,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain.

Shimizu M, Miyamoto Y, Kobayashi E, Shimazaki M, Yamamoto K, Reischl W, Yamada S.

Bioorg Med Chem. 2006 Jun 15;14(12):4277-94. Epub 2006 Feb 24.

PMID:
16503143
[PubMed - indexed for MEDLINE]
7.

An analog of 1alpha,25-dihydroxy-19-norvitamin D3 with the 1alpha-hydroxy group fixed in the axial position lacks biological activity in vitro.

Sicinski RR, Glebocka A, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):293-7. Epub 2007 Jan 12.

PMID:
17223547
[PubMed - indexed for MEDLINE]
8.

Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.

Marczak S, Przezdziecka A, Wicha J, Steinmeyer A, Zügel U.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):63-6.

PMID:
11140735
[PubMed - indexed for MEDLINE]
10.

Asymmetric catalytic ene-cyclization approach to 2-fluoro-19-nor-1,25-dihydroxyvitamin D(3) A-ring analog with significant transactivation activity.

Mikami K, Ohba S, Ohmura H, Kubodera N, Nakagawa K, Okano T.

Chirality. 2001 Jul;13(7):366-71.

PMID:
11400190
[PubMed - indexed for MEDLINE]
11.

Recent results on A-ring modification of 1alpha,25-dihydroxyvitamin D3: design and synthesis of VDR-agonists and antagonists with high biological activity.

Saito N, Honzawa S, Kittaka A.

Curr Top Med Chem. 2006;6(12):1273-88.

PMID:
16848741
[PubMed - indexed for MEDLINE]
12.

Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3.

Ikeda M, Takahashi K, Dan A, Koyama K, Kubota K, Tanaka T, Hayashi M.

Bioorg Med Chem. 2000 Aug;8(8):2157-66.

PMID:
11003160
[PubMed - indexed for MEDLINE]
13.

Efficient and versatile synthesis of novel 2alpha-substituted 1alpha,25-dihydroxyvitamin D(3) analogues and their docking to vitamin D receptors.

Suhara Y, Nihei KI, Kurihara M, Kittaka A, Yamaguchi K, Fujishima T, Konno K, Miyata N, Takayama H.

J Org Chem. 2001 Dec 28;66(26):8760-71.

PMID:
11749604
[PubMed - indexed for MEDLINE]
14.
15.

2-Methylene analogs of 1alpha-hydroxy-19-norvitamin D3: synthesis, biological activities and docking to the ligand binding domain of the rat vitamin D receptor.

Grzywacz P, Plum LA, Sicinska W, Sicinski RR, Prahl JM, DeLuca HF.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):13-7.

PMID:
15225739
[PubMed - indexed for MEDLINE]
16.

New derivative of 1alpha,25-dihydroxy-19-norvitamin D3 with 3'-alkoxypropylidene moiety at C-2: synthesis, biological activity and conformational analysis.

Glebocka A, Sicinski RR, DeLuca HF.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):25-30.

PMID:
15225741
[PubMed - indexed for MEDLINE]
17.

Functionalization at C-12 of 1alpha,25-dihydroxyvitamin D(3) strongly modulates the affinity for the vitamin D receptor (VDR).

González-Avión XC, Mouriño A.

Org Lett. 2003 Jun 26;5(13):2291-3.

PMID:
12816431
[PubMed - indexed for MEDLINE]
18.

Synthesis and biological activity of 22-iodo- and (E)-20(22)-dehydro analogues of 1alpha,25-dihydroxyvitamin D3.

Sicinski RR, DeLuca HF.

Bioorg Med Chem. 1999 Dec;7(12):2877-89.

PMID:
10658592
[PubMed - indexed for MEDLINE]
19.

C-6 functionalized analogs of 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3: synthesis and binding analysis with vitamin D-binding protein and vitamin D receptor.

Addo JK, Swamy N, Ray R.

Steroids. 1999 Apr;64(4):273-82. Erratum in: Steroids 2000 Apr;65(4):225.

PMID:
10399884
[PubMed - indexed for MEDLINE]
20.

A concise and efficient route to 2alpha-(omega-hydroxyalkoxy)-1alpha,25-dihydroxyvi tam in D3: remarkably high affinity to vitamin D receptor.

Kittaka A, Suhara Y, Takayanagi H, Fujishima T, Kurihara M, Takayama H.

Org Lett. 2000 Aug 24;2(17):2619-22.

PMID:
10990411
[PubMed - indexed for MEDLINE]

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