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Items: 1 to 20 of 160

1.

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

Helland Å, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ; Australian Ovarian Cancer Study Group, Pearson RB, Børresen-Dale AL, Huntsman DG, deFazio A, Creighton CJ, Smyth GK, Bowtell DD.

PLoS One. 2011 Apr 13;6(4):e18064. doi: 10.1371/journal.pone.0018064.

2.

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH.

Nat Genet. 2012 Nov;44(11):1199-206. doi: 10.1038/ng.2436. Epub 2012 Oct 7.

PMID:
23042116
3.

MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging.

Keane M, de Magalhães JP.

Mech Ageing Dev. 2013 Jul-Aug;134(7-8):346-8. doi: 10.1016/j.mad.2013.04.006. Epub 2013 Apr 29. Review.

PMID:
23639551
4.

HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma.

Mahajan A, Liu Z, Gellert L, Zou X, Yang G, Lee P, Yang X, Wei JJ.

Mod Pathol. 2010 May;23(5):673-81. doi: 10.1038/modpathol.2010.49. Epub 2010 Mar 12.

5.

[Overexpression of high mobility group A2 and its correlation with microRNA let-7 family in serous ovarian cancers].

Yang J, Zhang Q, Dong JQ, Chang XH, He XJ.

Beijing Da Xue Xue Bao. 2012 Oct 18;44(5):749-54. Chinese.

6.

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma.

Buechner J, Tømte E, Haug BH, Henriksen JR, Løkke C, Flægstad T, Einvik C.

Br J Cancer. 2011 Jul 12;105(2):296-303. doi: 10.1038/bjc.2011.220. Epub 2011 Jun 7.

7.

MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma.

Haug BH, Henriksen JR, Buechner J, Geerts D, Tømte E, Kogner P, Martinsson T, Flægstad T, Sveinbjørnsson B, Einvik C.

Carcinogenesis. 2011 Jul;32(7):1005-12. doi: 10.1093/carcin/bgr073. Epub 2011 May 13.

8.

Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma.

McMillen BD, Aponte MM, Liu Z, Helenowski IB, Scholtens DM, Buttin BM, Wei JJ.

Mod Pathol. 2012 Dec;25(12):1644-53. doi: 10.1038/modpathol.2012.118. Epub 2012 Jul 13.

9.

ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas.

Wang Q, Hii G, Shusterman S, Mosse Y, Winter CL, Guo C, Zhao H, Rappaport E, Hogarty MD, Maris JM.

Cancer Res. 2003 Apr 1;63(7):1631-5.

10.

Expression of MYCN in pediatric synovial sarcoma.

Somers GR, Zielenska M, Abdullah S, Sherman C, Chan S, Thorner PS.

Mod Pathol. 2007 Jul;20(7):734-41. Epub 2007 Apr 27.

11.

MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC.

Alam M, Ahmad R, Rajabi H, Kufe D.

Mol Cancer Res. 2015 Mar;13(3):449-60. doi: 10.1158/1541-7786.MCR-14-0363. Epub 2014 Nov 3.

12.

Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas.

Brown LA, Irving J, Parker R, Kim H, Press JZ, Longacre TA, Chia S, Magliocco A, Makretsov N, Gilks B, Pollack J, Huntsman D.

Gynecol Oncol. 2006 Feb;100(2):264-70. Epub 2005 Oct 19.

PMID:
16236351
13.

Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis.

Murphy DM, Buckley PG, Bryan K, Watters KM, Koster J, van Sluis P, Molenaar J, Versteeg R, Stallings RL.

Mol Carcinog. 2011 Jun;50(6):403-11. doi: 10.1002/mc.20722. Epub 2010 Dec 28.

PMID:
21557326
14.

LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels.

Murray MJ, Saini HK, Siegler CA, Hanning JE, Barker EM, van Dongen S, Ward DM, Raby KL, Groves IJ, Scarpini CG, Pett MR, Thornton CM, Enright AJ, Nicholson JC, Coleman N; CCLG.

Cancer Res. 2013 Aug 1;73(15):4872-84. doi: 10.1158/0008-5472.CAN-12-2085. Epub 2013 Jun 17.

15.

The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes.

Eide HA, Halvorsen AR, Bjaanæs MM, Piri H, Holm R, Solberg S, Jørgensen L, Brustugun OT, Kiserud CE, Helland Å.

BMC Cancer. 2016 Feb 8;16:71. doi: 10.1186/s12885-016-2104-9.

16.

Lin28 promotes transformation and is associated with advanced human malignancies.

Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ.

Nat Genet. 2009 Jul;41(7):843-8. doi: 10.1038/ng.392. Epub 2009 May 31.

17.

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.

Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Traficante N, Fereday S, Hung JA, Chiew YE, Haviv I; Australian Ovarian Cancer Study Group, Gertig D, DeFazio A, Bowtell DD.

Clin Cancer Res. 2008 Aug 15;14(16):5198-208. doi: 10.1158/1078-0432.CCR-08-0196.

18.

Clinical significance of a highly sensitive analysis for gene dosage and the expression level of MYCN in neuroblastoma.

Tanaka S, Tajiri T, Noguchi S, Shono K, Ihara K, Hara T, Suita S.

J Pediatr Surg. 2004 Jan;39(1):63-8.

PMID:
14694373
19.

Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State.

Chien CS, Wang ML, Chu PY, Chang YL, Liu WH, Yu CC, Lan YT, Huang PI, Lee YY, Chen YW, Lo WL, Chiou SH.

Cancer Res. 2015 Jun 15;75(12):2553-65. doi: 10.1158/0008-5472.CAN-14-2215. Epub 2015 Apr 9.

PMID:
25858147
20.

Inhibition of mir-21, which is up-regulated during MYCN knockdown-mediated differentiation, does not prevent differentiation of neuroblastoma cells.

Buechner J, Henriksen JR, Haug BH, Tømte E, Flaegstad T, Einvik C.

Differentiation. 2011 Jan;81(1):25-34. doi: 10.1016/j.diff.2010.09.184. Epub 2010 Oct 25.

PMID:
20980091
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