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Items: 1 to 20 of 90

1.

The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation.

Strøm TB, Tveten K, Holla ØL, Cameron J, Berge KE, Leren TP.

Biochem Biophys Res Commun. 2011 May 20;408(4):642-6. doi: 10.1016/j.bbrc.2011.04.077. Epub 2011 Apr 21.

PMID:
21531209
2.

Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification.

Tveten K, Holla ØL, Cameron J, Strøm TB, Berge KE, Laerdahl JK, Leren TP.

Hum Mol Genet. 2012 Mar 15;21(6):1402-9. doi: 10.1093/hmg/ddr578. Epub 2011 Dec 8.

3.

The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.

Tveten K, Ranheim T, Berge KE, Leren TP, Kulseth MA.

Acta Biochim Biophys Sin (Shanghai). 2009 Mar;41(3):246-55.

4.

Intracellular fate of LDL receptor family members depends on the cooperation between their ligand-binding and EGF domains.

Van Hoof D, Rodenburg KW, Van der Horst DJ.

J Cell Sci. 2005 Mar 15;118(Pt 6):1309-20. Epub 2005 Mar 1.

5.

Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain.

Strøm TB, Holla ØL, Tveten K, Cameron J, Berge KE, Leren TP.

Mol Genet Metab. 2010 Sep;101(1):76-80. doi: 10.1016/j.ymgme.2010.05.003. Epub 2010 Jun 9.

PMID:
20659812
6.

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.

Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG.

Traffic. 2007 Jun;8(6):718-32. Epub 2007 Apr 25. Erratum in: Traffic. 2007 Jul;8(7):950.

7.

A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9.

Holla ØL, Strøm TB, Cameron J, Berge KE, Leren TP.

Mol Genet Metab. 2010 Feb;99(2):149-56. doi: 10.1016/j.ymgme.2009.09.012. Epub 2009 Sep 27.

PMID:
19828345
8.

The important role for betaVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor.

Iwasaki T, Takahashi S, Ishihara M, Takahashi M, Ikeda U, Shimada K, Fujino T, Yamamoto TT, Hattori H, Emi M.

J Hum Genet. 2004;49(11):622-8. Epub 2004 Oct 1.

PMID:
15459764
9.

Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation.

Fisher TS, Lo Surdo P, Pandit S, Mattu M, Santoro JC, Wisniewski D, Cummings RT, Calzetta A, Cubbon RM, Fischer PA, Tarachandani A, De Francesco R, Wright SD, Sparrow CP, Carfi A, Sitlani A.

J Biol Chem. 2007 Jul 13;282(28):20502-12. Epub 2007 May 10.

10.

Sorting an LDL receptor with bound PCSK9 to intracellular degradation.

Leren TP.

Atherosclerosis. 2014 Nov;237(1):76-81. doi: 10.1016/j.atherosclerosis.2014.08.038. Epub 2014 Sep 2. Review.

PMID:
25222343
11.

Model system for phenotypic characterization of sequence variations in the LDL receptor gene.

Ranheim T, Kulseth MA, Berge KE, Leren TP.

Clin Chem. 2006 Aug;52(8):1469-79. Epub 2006 Jun 1.

12.

Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.

Li Y, Lu W, Schwartz AL, Bu G.

J Lipid Res. 2004 Jun;45(6):1084-91. Epub 2004 Mar 1.

13.

Characterization of residues in the cytoplasmic domain of the LDL receptor required for exit from the endoplasmic reticulum.

Strøm TB, Tveten K, Holla ØL, Cameron J, Berge KE, Leren TP.

Biochem Biophys Res Commun. 2011 Dec 2;415(4):642-5. doi: 10.1016/j.bbrc.2011.10.127. Epub 2011 Nov 2.

PMID:
22079632
14.

The complex of the insect LDL receptor homolog, lipophorin receptor, LpR, and its lipoprotein ligand does not dissociate under endosomal conditions.

Roosendaal SD, Kerver J, Schipper M, Rodenburg KW, Van der Horst DJ.

FEBS J. 2008 Apr;275(8):1751-66. doi: 10.1111/j.1742-4658.2008.06334.x. Epub 2008 Mar 7.

15.

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.

Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG.

J Biol Chem. 2008 Jan 25;283(4):2363-72. Epub 2007 Nov 26.

17.

Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection.

Konecsni T, Berka U, Pickl-Herk A, Bilek G, Khan AG, Gajdzig L, Fuchs R, Blaas D.

J Virol. 2009 Nov;83(21):10922-30. doi: 10.1128/JVI.01312-09. Epub 2009 Aug 12.

18.

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.

Arias-Moreno X, Velazquez-Campoy A, Rodríguez JC, Pocoví M, Sancho J.

J Biol Chem. 2008 Aug 15;283(33):22670-9. doi: 10.1074/jbc.M802153200. Epub 2008 Jun 23.

19.

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH.

J Biol Chem. 2007 Jun 22;282(25):18602-12. Epub 2007 Apr 23.

20.
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