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Results: 1 to 20 of 173

1.

Structural basis for methyl transfer by a radical SAM enzyme.

Boal AK, Grove TL, McLaughlin MI, Yennawar NH, Booker SJ, Rosenzweig AC.

Science. 2011 May 27;332(6033):1089-92. doi: 10.1126/science.1205358. Epub 2011 Apr 28.

PMID:
21527678
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.

Grove TL, Radle MI, Krebs C, Booker SJ.

J Am Chem Soc. 2011 Dec 14;133(49):19586-9. doi: 10.1021/ja207327v. Epub 2011 Nov 18.

PMID:
21916495
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.

Grove TL, Benner JS, Radle MI, Ahlum JH, Landgraf BJ, Krebs C, Booker SJ.

Science. 2011 Apr 29;332(6029):604-7. doi: 10.1126/science.1200877. Epub 2011 Mar 17.

PMID:
21415317
[PubMed - indexed for MEDLINE]
Free Article
4.

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria.

Kaminska KH, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS.

Nucleic Acids Res. 2010 Mar;38(5):1652-63. doi: 10.1093/nar/gkp1142. Epub 2009 Dec 10.

PMID:
20007606
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.

Yan F, LaMarre JM, Röhrich R, Wiesner J, Jomaa H, Mankin AS, Fujimori DG.

J Am Chem Soc. 2010 Mar 24;132(11):3953-64. doi: 10.1021/ja910850y.

PMID:
20184321
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift.

Yan F, Fujimori DG.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3930-4. doi: 10.1073/pnas.1017781108. Epub 2011 Feb 22.

PMID:
21368151
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.

McCusker KP, Medzihradszky KF, Shiver AL, Nichols RJ, Yan F, Maltby DA, Gross CA, Fujimori DG.

J Am Chem Soc. 2012 Oct 31;134(43):18074-81. doi: 10.1021/ja307855d. Epub 2012 Oct 22.

PMID:
23088750
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Radical-mediated enzymatic methylation: a tale of two SAMS.

Zhang Q, van der Donk WA, Liu W.

Acc Chem Res. 2012 Apr 17;45(4):555-64. doi: 10.1021/ar200202c. Epub 2011 Nov 18. Review.

PMID:
22097883
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Biochemistry. The two faces of SAM.

Stubbe J.

Science. 2011 Apr 29;332(6029):544-5. doi: 10.1126/science.1204209. No abstract available.

PMID:
21527702
[PubMed - indexed for MEDLINE]
10.

Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.

Atkinson GC, Hansen LH, Tenson T, Rasmussen A, Kirpekar F, Vester B.

Antimicrob Agents Chemother. 2013 Aug;57(8):4019-26. doi: 10.1128/AAC.00448-13. Epub 2013 Jun 10.

PMID:
23752511
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Radical SAM-dependent carbon insertion into the nitrogenase M-cluster.

Wiig JA, Hu Y, Lee CC, Ribbe MW.

Science. 2012 Sep 28;337(6102):1672-5.

PMID:
23019652
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins.

Lanz ND, Grove TL, Gogonea CB, Lee KH, Krebs C, Booker SJ.

Methods Enzymol. 2012;516:125-52. doi: 10.1016/B978-0-12-394291-3.00030-7.

PMID:
23034227
[PubMed - indexed for MEDLINE]
13.

Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase.

Challand MR, Salvadori E, Driesener RC, Kay CW, Roach PL, Spencer J.

PLoS One. 2013 Jul 5;8(7):e67979. doi: 10.1371/journal.pone.0067979. Print 2013.

PMID:
23861844
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes.

Sunita S, Tkaczuk KL, Purta E, Kasprzak JM, Douthwaite S, Bujnicki JM, Sivaraman J.

J Mol Biol. 2008 Nov 14;383(3):652-66. doi: 10.1016/j.jmb.2008.08.062. Epub 2008 Aug 29.

PMID:
18789337
[PubMed - indexed for MEDLINE]
15.

Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA.

Punekar AS, Shepherd TR, Liljeruhm J, Forster AC, Selmer M.

Nucleic Acids Res. 2012 Nov 1;40(20):10507-20. doi: 10.1093/nar/gks727. Epub 2012 Aug 25.

PMID:
22923526
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function.

Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC.

Nature. 2013 Jun 6;498(7452):123-6. doi: 10.1038/nature12180. Epub 2013 May 15.

PMID:
23676670
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA.

Dunstan MS, Hang PC, Zelinskaya NV, Honek JF, Conn GL.

J Biol Chem. 2009 Jun 19;284(25):17013-20. doi: 10.1074/jbc.M901618200. Epub 2009 Apr 15.

PMID:
19369248
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ.

Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M.

Nucleic Acids Res. 2013 Nov 1;41(20):9537-48. doi: 10.1093/nar/gkt719. Epub 2013 Aug 13.

PMID:
23945937
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme.

Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL.

Science. 2004 Jan 2;303(5654):76-9.

PMID:
14704425
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Catalytic mechanism of glycine N-methyltransferase.

Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F.

Biochemistry. 2003 Jul 22;42(28):8394-402. Erratum in: Biochemistry. 2003 Sep 16;42(36):10874.

PMID:
12859184
[PubMed - indexed for MEDLINE]

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