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Items: 1 to 20 of 112

1.

In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.

Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM.

Biophys J. 2011 Apr 20;100(8):1893-901. doi: 10.1016/j.bpj.2011.02.047.

2.

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.

Weiger MC, Wang CC, Krajcovic M, Melvin AT, Rhoden JJ, Haugh JM.

J Cell Sci. 2009 Feb 1;122(Pt 3):313-23. doi: 10.1242/jcs.037564. Epub 2009 Jan 6.

3.

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism.

Welf ES, Ahmed S, Johnson HE, Melvin AT, Haugh JM.

J Cell Biol. 2012 Apr 2;197(1):105-14. doi: 10.1083/jcb.201108152.

4.

Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB.

Rosenmüller T, Rydh K, Nånberg E.

J Cell Physiol. 2001 Sep;188(3):369-82.

PMID:
11473364
5.

Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing.

Haugh JM.

Biophys J. 2006 Apr 1;90(7):2297-308. Epub 2006 Jan 13. Erratum in: Biophys J. 2007 Jan 15;92(2):696.

7.

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts.

Schneider IC, Haugh JM.

J Cell Biol. 2005 Dec 5;171(5):883-92. Epub 2005 Nov 28.

8.

EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.

Rosenfeldt HM, Hobson JP, Maceyka M, Olivera A, Nava VE, Milstien S, Spiegel S.

FASEB J. 2001 Dec;15(14):2649-59.

9.

Specific inhibition of human skin fibroblast chemotaxis to platelet-derived growth factor A-chain homodimer by transforming growth factor-beta1.

Soma Y, Mizoguchi M, Yamane K, Yazawa N, Kubo M, Ihn H, Kikuchi K, Tamaki K.

Arch Dermatol Res. 2002 Feb;293(12):609-13. Epub 2002 Jan 23.

PMID:
11875643
10.

Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis.

Higaki M, Sakaue H, Ogawa W, Kasuga M, Shimokado K.

J Biol Chem. 1996 Nov 15;271(46):29342-6.

11.

Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties.

Monine MI, Haugh JM.

Cell Adh Migr. 2008 Apr-May;2(2):137-46. Epub 2008 Apr 26.

12.

Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis.

De Donatis A, Comito G, Buricchi F, Vinci MC, Parenti A, Caselli A, Camici G, Manao G, Ramponi G, Cirri P.

J Biol Chem. 2008 Jul 18;283(29):19948-56. doi: 10.1074/jbc.M709428200. Epub 2008 May 21.

13.
14.

Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species.

Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, Rosenkranz S.

J Biol Chem. 2008 Mar 21;283(12):7864-76. Epub 2007 Dec 10.

15.

Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling.

Platek A, Vassilev VS, de Diesbach P, Tyteca D, Mettlen M, Courtoy PJ.

Exp Cell Res. 2007 Apr 1;313(6):1090-105. Epub 2007 Feb 6.

PMID:
17335807
16.

Platelet-derived growth factor (PDGF)-AA, -AB, and -BB induce differential chemotaxis of early-passage rat lung fibroblasts in vitro.

Osornio-Vargas AR, Goodell AL, Hernández-Rodríguez NA, Brody AR, Coin PG, Badgett A, Bonner JC.

Am J Respir Cell Mol Biol. 1995 Jan;12(1):33-40.

PMID:
7811469
17.

Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts.

Nagano K, Akpan A, Warnasuriya G, Corless S, Totty N, Yang A, Stein R, Zvelebil M, Stensballe A, Burlingame A, Waterfield M, Cramer R, Timms JF, Naaby-Hansen S.

Mol Cell Proteomics. 2012 Dec;11(12):1690-708. doi: 10.1074/mcp.M112.019778. Epub 2012 Sep 6.

18.

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.

Takahashi Y, Morales FC, Kreimann EL, Georgescu MM.

EMBO J. 2006 Feb 22;25(4):910-20. Epub 2006 Feb 2.

19.
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